A Lewis Acid-Catalyzed Cascade Synthesis of Fused N-Heterocycles from 2-Alkynylanilines and 2-Formylbenzonitriles: Unveiling Iminoisoindoloindolone and Its Derivatives
Pallav Jyoti Arandhara,
Archana Chutia,
Subhamoy Biswas
et al.
Abstract:We herein reveal a streamlined synthesis of structurally fused 6-iminoisoindoloindolones via a meticulously orchestrated cascade reaction. This process seamlessly intertwines 2-alkynylaniline and 2-formylbenzonitrile under the catalytic influence of TMSOTf, giving rise to these compounds in remarkable yields that stand as a testament to the efficiency of our approach. Moreover, the versatility of this synthetic strategy extends far beyond mere synthesis, offering a gateway to the creation of both isoindoloindo… Show more
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