A Lethal Disease Model for Hantavirus Pulmonary Syndrome

Hooper, Jay W.; Larsen, Tom; Custer, David; Schmaljohn, Connie S.

doi:10.1006/viro.2001.1133

Cited by 231 publications

(319 citation statements)

References 15 publications

(16 reference statements)

Supporting

Mentioning

305

Contrasting

Unclassified

Order By: Relevance

“…23 The high frequency of HV fever and mild HPS in Choclo virus infection contrasted with the high mortality in Andes virus Table 6 Laboratory findings at first clinic visit for all diagnostic categories infection may reflect the highly specific interaction between HV species and the host integrin receptors. 24 Andes virus is uniformly lethal in hamsters, 25,26 and viral glycoprotein-integrin interaction is highly specific. 27 However, in hamsters infected with Choclo virus, robust viral replication in the lung is not accompanied by pulmonary inflammation or mortality.…”

Section: Discussionmentioning

confidence: 99%

Hantavirus Fever without Pulmonary Syndrome in Panama

Armién¹,

Pascale²,

Muñoz³

et al. 2013

The American Society of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Abstract. In Panama, hantavirus pulmonary syndrome (HPS) is caused by Choclo virus, a species phylogenetically related to Andes and Maporal viruses. Up to 60% of the population has been positive for specific serum antibody in community-based surveys, but mortality is very uncommon. In four western Panama clinics, we tested individuals presenting with a severe febrile prodrome for acute hantavirus (HV) infection by immunoglobulin M enzyme-linked immunosorbent assay and reverse transcription polymerase chain reaction as well as clinically similar infections, such as dengue and leptospirosis. From 2006 to 2009, at least 21% of 117 patients diagnosed with HV infection had HV Fever (HF) with no evidence of pulmonary edema (no respiratory distress or radiographic lung infiltrates), and 44% of patients had very mild HPS (radiographic pulmonary edema but no respiratory insufficiency). HV infection caused by Choclo virus in Panama presents often as HF, which contrasts with HV in the Americas but is consistent with the high seroprevalence in endemic regions.

show abstract

Section: Discussionmentioning

confidence: 99%

Hantavirus Fever without Pulmonary Syndrome in Panama

Armién¹,

Pascale²,

Muñoz³

et al. 2013

The American Society of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

show abstract

“…The dichotomy of immune responses between humans and rodent reservoirs also suggests that TGF-␤ 1 may be a potential therapeutic agent for treating immunopathologies caused by hantaviruses, which could abrogate the fatal inflammation associated with HCPS. Hamster models of HCPS are available that have similar pathogenesis to human HCPS (61)(62)(63) and could be used to test this hypothesis. The use of corticosteroid antiinflammatory approaches to hantavirus disease has had recent success (64); however, further work will be required to determine whether antiinflammatory cytokine therapies can be used safely and effectively without causing persistent infection.…”

Section: Discussionmentioning

confidence: 99%

Regulatory T cell-like responses in deer mice persistently infected with Sin Nombre virus

Schountz

Prescott²,

Cogswell³

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

107

View full text Add to dashboard Cite

Hantavirus cardiopulmonary syndrome is a zoonotic illness associated with a systemic inflammatory immune response, capillary leak, noncardiogenic pulmonary edema, and shock in humans. Cytokines, including TNF, IFN-␥, and lymphotoxin, are thought to contribute to its pathogenesis. In contrast, infected rodent reservoirs of hantaviruses experience few or no pathologic changes and the host rodent can remain persistently infected for life. Generally, it is unknown why such dichotomous immune responses occur between humans and reservoir hosts. Thus, we examined CD4 ؉ T cell responses from one such reservoir, the deer mouse (Peromy-

show abstract

“…However, SNV does not cause disease in infected mice. Some strains of New World hantaviruses, although not SNV, have been shown to cause disease in Syrian golden hamsters (34,35), but few immunologic reagents exist for studying hamsters. Thus, it is necessary to study HPS in patients infected with SNV.…”

Section: Virus-specific Cd8mentioning

confidence: 99%

Role of Specific CD8+ T Cells in the Severity of a Fulminant Zoonotic Viral Hemorrhagic Fever, Hantavirus Pulmonary Syndrome

Kilpatrick¹,

Terajima²,

Koster

et al. 2004

The Journal of Immunology

154

174

View full text Add to dashboard Cite

We report on the role of specific CD8+ T cells in the pathogenesis of a highly lethal human viral disease, hantavirus pulmonary syndrome (HPS). HPS is a zoonotic disease caused by transmission of Sin Nombre virus (SNV) from chronically infected deer mice. In humans, this fulminant infection is characterized by lung capillary leakage, respiratory failure, and cardiogenic shock. Individuals with HLA-B*3501 have an increased risk of developing severe HPS, suggesting that CD8+ T cell responses to SNV contribute to pathogenesis. We identified three CD8+ T cell epitopes in SNV presented by HLA-B*3501 and quantitated circulating SNV-specific CD8+ T cells in 11 acute HPS patients using HLA/peptide tetramers. We found significantly higher frequencies of SNV-specific T cells in patients with severe HPS requiring mechanical ventilation (up to 44.2% of CD8+ T cells) than in moderately ill HPS patients hospitalized but not requiring mechanical ventilation (up to 9.8% of CD8+ T cells). These results imply that virus-specific CD8+ T cells contribute to HPS disease outcome. Intense CD8+ T cell responses to SNV may be induced by the encounter of the unnatural human host to this zoonotic virus without coevolution. This may also be the immunopathologic basis of other life-threatening human virus infections.

show abstract

A Lethal Disease Model for Hantavirus Pulmonary Syndrome

Cited by 231 publications

References 15 publications

Hantavirus Fever without Pulmonary Syndrome in Panama

Hantavirus Fever without Pulmonary Syndrome in Panama

Regulatory T cell-like responses in deer mice persistently infected with Sin Nombre virus

Role of Specific CD8+ T Cells in the Severity of a Fulminant Zoonotic Viral Hemorrhagic Fever, Hantavirus Pulmonary Syndrome

Contact Info

Product

Resources

About