Tumors of the skin/skin adnexa are astonishingly diverse. The diagnostic algorithms for skin neoplasms includes history taking, the assessment of clinical data, dermoscopy and a histopathological examination. Literature descriptions of a histologically confirmed pilomatricoma are scarce. If the lesion is localized to an esthetically sensitive body area, it is important to minimize the postoperative cosmetic defect. In the case described below, we were able to achieve a positive esthetic outcome in a patient with a facial pilomatricoma sized < 2 cm2 using a СО2 laser.