A lesion of the posterior parietal cortex disrupts on-line adjustments during aiming movements

Gréa, Hélène; Pisella, Laure; Rossetti, Yves; Desmurget, Michel; Tilikete, Caroline; Grafton, Scott T.; Prablanc, Claude; Vighetto, Alain

doi:10.1016/s0028-3932(02)00009-x

Cited by 239 publications

(147 citation statements)

References 48 publications

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“…Taken together, the present results suggest that targets and obstacles are treated differently when controlling hand movements. It has been shown that specialized pathways through the parietal cortex continuously monitor target position so that the hand's trajectory can rapidly be adjusted during its movement (Desmurget et al 1999;Gréa et al 2002;Pisella et al 2000). Our results suggest that obstacles might not have access to such dedicated pathways.…”

Section: Discussionmentioning

confidence: 76%

Avoiding moving obstacles

2008

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To successfully move our hand to a target, we must consider how to get there without hitting surrounding objects. In a dynamic environment this involves being able to respond quickly when our relationship with surrounding objects changes. People adjust their hand movements with a latency of about 120 ms when the visually perceived position of their hand or of the target suddenly changes. It is not known whether people can react as quickly when the position of an obstacle changes. Here we show that quick responses of the hand to changes in obstacle position are possible, but that these responses are direct reactions to the motion in the surrounding. True adjustments to the changed position of the obstacle appeared at much longer latencies (about 200 ms). This is even so when the possible change is predictable. Apparently, our brain uses certain information exceptionally quickly for guiding our movements, at the expense of not always responding adequately. For reaching a target that changes position, one must at some time move in the same direction as the target did. For avoiding obstacles that change position, moving in the same direction as the obstacle is not always an adequate response, not only because it may be easier to avoid the obstacle by moving the other way, but also because one wants to hit the target after passing the obstacle. Perhaps subjects nevertheless quickly respond in the direction of motion because this helps avoid collisions when pressed for time.

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Section: Discussionmentioning

confidence: 76%

Avoiding moving obstacles

2008

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“…The posterior parietal cortex (PPC) contains a population of neurons implicated in the control of the configuration and orientation of the hand during active reach and grasping (Sakata et al, 1997;Murata et al, 2000). Observations from optic ataxic patients (Pisella et al, 2000;Gréa et al, 2002) and from transcranial magnetic stimulation (Desmurget et al, 1999;Tunik et al, 2005;Rice et al, 2006) and imaging (Culham et al, 2003;Frey et al, 2005;Tunik et al, 2008) studies suggested that one dorsal stream function is an automatic vision-based on-line error-correction mechanism that involves the PPC (Desmurget and Grafton, 2000;Glover, 2004;Buneo and Andersen, 2006;Iacoboni, 2006).…”

Section: Proprioceptive Integration For Perception Action and On-limentioning

confidence: 99%

“…Many studies have reported rapid automatic on-line adjustments for hand spatial location and grip aperture during reaching and grasping Pélisson et al, 1986;Prablanc and Martin, 1992;Desmurget et al, 1999;Day and Lyon, 2000;Desmurget and Grafton, 2000;Gréa et al, 2002;Knill, 2004, 2005). In contrast, few studies have investigated such mechanisms for spatial hand orientation (Glover and Dixon, 2001a,b,c;Tunik et al, 2005;Fan et al, 2006;Gosselin-Kessiby et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Evidence for a Proprioception-Based Rapid On-Line Error Correction Mechanism for Hand Orientation during Reaching Movements in Blind Subjects

Gosselin-Kessiby

Kalaska²,

Messier³

2009

J. Neurosci.

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The contribution of visual experience to the perception and sensorimotor control of spatial orientation of the hand was investigated in blind subjects. In "orientation-matching" tasks, subjects aligned a match handle held in their right hand to a target handle held in their left hand and fixed in different orientations, with both arms outstretched. In "letter-posting" task 1, the same subjects reached out and simultaneously oriented their right hand to insert the match handle into a target slot fixed in the same range of orientations. Orientations were signaled proprioceptively by a reference handle held in the left hand. Final hand orientation errors were smaller when blind subjects simultaneously reached out and rotated their hand to insert the match handle into the target slot in letter-posting task 1 than when they held their arm extended and aligned the handles in the orientation-matching task. In letter-posting task 2, blind subjects first aligned their hand to the orientation of the target and then subsequently reached to the target with the instruction to not change hand orientation during reaching. Despite the instruction, subjects showed a reduction in absolute hand orientation error from the beginning to the end of the reach. In all tasks, performance of blind subjects was very similar to that of blindfolded normally sighted subjects. These findings provide the first evidence of an automatic on-line error-correction mechanism for hand orientation guided only by proprioceptive inputs during reaching in blind subjects, and reveal that the on-line mechanism does not depend on prior visual experience.

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“…Furthermore, parietal lesion can result in delayed and impaired trajectory corrections when a sudden shift of target location occurs (Pisella et al, 2000;Gréa et al, 2002;BattagliaMayer et al, 2006). Given the corticocortical relationships within the parietofrontal networks (see Averbeck et al, 2009), it is reasonable to assume that the information used by motor cortical cells to update hand movement trajectory, at least in part, comes from PMd.…”

Section: Introductionmentioning

confidence: 99%

Online Control of Hand Trajectory and Evolution of Motor Intention in the Parietofrontal System

Archambault¹,

Ferrari-Toniolo²,

Battaglia-Mayer³

2011

J. Neurosci.

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The frontal mechanisms of motor intention were studied in dorsal premotor and motor cortex of monkeys making direct reaches to visual targets and online corrections of hand trajectory, whenever a change of the target's location occurred. This study and our previous one of parietal cortex (Archambault et al., 2009) provide a picture on the evolution of motor intention and online control of movement in the parietofrontal system. In frontal cortex, significant relationships were found between neural activity and hand kinematics (position, speed, and movement direction). When a change of motor intention occurred, the activity typical of the movement to the first target smoothly evolved into that associated with the movement toward the second one, as observed during direct reaches. Under these conditions, parietal cells remained a more accurate predictor of hand trajectory than frontal ones. The time lags of neural activity with hand kinematics showed that motor, premotor, and parietal cortex were activated sequentially. After the first target's presentation and its change of location, the population activity signaled the change of motor plan before the hand moved to the initial target's position. This signaling occurred earlier in premotor than in motor and parietal cortex. Thus, premotor cortex encodes a higher-order command for the correction of motor intention, while parietal cortex seems responsible for estimating the kinematics of the motor periphery, an essential step to allow motor cortex to modify the hand trajectory. This indicates that the parietofrontal system can update an original and not-yet-accomplished motor plan during its execution.

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A lesion of the posterior parietal cortex disrupts on-line adjustments during aiming movements

Cited by 239 publications

References 48 publications

Avoiding moving obstacles

Avoiding moving obstacles

Evidence for a Proprioception-Based Rapid On-Line Error Correction Mechanism for Hand Orientation during Reaching Movements in Blind Subjects

Online Control of Hand Trajectory and Evolution of Motor Intention in the Parietofrontal System

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