A legume-based hypocaloric diet reduces proinflammatory status and improves metabolic features in overweight/obese subjects

Hermsdorff, Helen Hermana Miranda; Zulet, M. Ángeles; Abete, Itziar; Martínéz, J. Alfredo

doi:10.1007/s00394-010-0115-x

Cited by 173 publications

(140 citation statements)

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“…Both interventions have been shown to reduce the expression and synthesis of pro-inflammatory cytokines (IL-6 and TNF-α) and decrease other inflammatory markers such as C-reactive protein (CRP). [10][11][12] In addition, previous studies have confirmed that high-fat meals reduce leptin concentrations and increase the activation of inflammatory markers such as IL-6 during the postprandial phase. 13,14 In fact, fatty acids can directly or indirectly modify immune and inflammatory responses.…”

Section: Inflammation Is a Physiological Response Triggered By Infectionmentioning

confidence: 84%

The role of dietary fatty acid intake in inflammatory gene expression: a critical review

2017

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CONTEXT AND OBJECTIVE: Diet is an important modifiable factor involved in obesity-induced inflammation. We reviewed clinical trials that assessed the effect of consumption of different fatty acids on the expression of inflammation-related genes, such as cytokines, adipokines, chemokines and transcription factors. DESIGN AND SETTING: Narrative review study conducted at a research center. METHODS:This was a review on the effect of fat intake on inflammatory gene expression in humans. RESULTS: Consumption of saturated fatty acids (SFAs) was related to postprandial upregulation of genes associated with pro-inflammatory pathways in peripheral blood mononuclear cells (PBMCs), in comparison with monounsaturated fatty acid (MUFA) or polyunsaturated fatty acid (PUFA) intake. In addition, acute intake of a high-SFA meal also induced a postprandial pro-inflammatory response for several inflammatory genes in subcutaneous adipose tissue. Both high-MUFA and high-PUFA diets showed anti-inflammatory profiles, or at least a less pronounced pro-inflammatory response than did SFA consumption. However, the results concerning the best substitute for SFAs were divergent because of the large variability in doses of MUFA (20% to 72% of energy intake) and n3 PUFA (0.4 g to 23.7% of energy intake) used in interventions. CONCLUSIONS: The lipid profile of the diet can modulate the genes relating to postprandial and longterm inflammation in PBMCs and adipose tissue. Identifying the optimal fat profile for inflammatory control may be a promising approach for treating chronic diseases such as obesity. RESUMO CONTEXTO E OBJETIVO:A dieta é um importante fator modificável envolvido na inflamação induzida pela obesidade. Nós revisamos ensaios clínicos que avaliaram o efeito do consumo de diferentes ácidos graxos sobre a expressão de genes relacionados com a inflamação, tais como citocinas, adipocitocinas, quimiocinas e fatores de transcrição. TIPO DE ESTUDO E LOCAL: Estudo de revisão narrativa realizado em um centro de pesquisa. MÉTODOS: Revisão do efeito da ingestão de gordura sobre a expressão de genes envolvidos com inflamação em seres humanos. RESULTADOS: O consumo do ácido graxo saturado (AGS) foi relacionado com a regulação favorável pós--prandial de genes associados com vias pró-inflamatórias nas células mononucleares de sangue periféri-co (CMSP), em comparação com a ingestão do ácido graxo monoinsaturado (AGMI) ou do ácido graxo poli-insaturado (AGPI). Além disso, o consumo agudo de uma dieta com alto conteúdo de AGS também induziu uma resposta pró-inflamatória pós-prandial para vários genes da inflamação no tecido adiposo subcutâneo. Ambas as dietas com alto conteúdo de AGMI e AGPI apresentaram perfil anti-inflamatório ou, pelo menos, menor resposta pró-inflamatória em relação ao consumo de AGS. Contudo, os resultados são controversos acerca do melhor substituto para o AGS, devido à grande variabilidade na dose de AGMI (20% a 72% da ingestão energética) e AGPI n3 (0,4 g para 23,7% da ingestão energética) utilizados nos estudos de...

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Section: Inflammation Is a Physiological Response Triggered By Infectionmentioning

confidence: 84%

The role of dietary fatty acid intake in inflammatory gene expression: a critical review

2017

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“…The pooled analyses sug- Anderson et al 22 Cobiac et al 24 Duane et al 7 Gravel et al 26 Hermsdorff et al 8 Jenkins et al 35 Marinangeli et al 38 Pittaway et al 28 Pittaway et al 29 Shams et al 30 Winham et al 31 Winham et al 20 (COM)…”

Section: Discussionmentioning

confidence: 99%

“…The effect between the intervention and the control diets did not differ significantly (mean difference −0.09 mmol/L, 95% CI −0.19 to 0.00 mmol/L); however, inter-study heterogeneity was very high (I 2 = 98%). Sensitivity analy- Zhang et al 32 ses showed that the pooled effect size became significant when any of the 6 trials that favoured the effect of the control diet 6,8,22,23,26,38 was removed. The use of a correlation coefficient of 0.25 did not alter conclusions, but a correlation coefficient of 0.75 resulted in a significant reduction in non-HDL cholesterol favouring the dietary pulse intervention.…”

Section: 29mentioning

confidence: 99%

Effect of dietary pulse intake on established therapeutic lipid targets for cardiovascular risk reduction: a systematic review and meta-analysis of randomized controlled trials

Sievenpiper

Souza

et al. 2014

CMAJ

153

101

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A bnormal blood concentrations of lipids are one of the most important modifiable risk factors for cardiovascular disease. Although statins are effective in reducing low-density lipoprotein (LDL) cholesterol levels, major health organizations have maintained that the initial and essential approach to the prevention and management of cardiovascular disease is to modify dietary and lifestyle patterns. 1−4Dietary non-oil-seed pulses (beans, chickpeas, lentils and peas) are foods that have received particular attention for their ability to reduce the risk of cardiovascular disease. Consumption of dietary pulses was associated with a reduction in cardiovascular disease in a large observational study 5 and with improvements in LDL cholesterol levels in small trials.6−8 Although most guidelines on the prevention of major chronic diseases encourage the consumption of dietary pulses as part of a healthy strategy, 2,3,9−13 none has included recommendations based on the direct benefits of lowering lipid concentrations or reducing the risk of cardiovascular disease. In all cases, the evidence on which recommendations have been based was assigned a low grade, 2,3,9−13 and dyslipidemia guidelines do not address dietary pulse intake directly. 1,4 To improve the evidence on which dietary guidelines are based, we conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) of the effect of dietary pulse intake on established therapeutic lipid targets for cardiovascular risk reduction. The lipid targets were LDL cholesterol, apolipoprotein B and nonhigh-density lipoprotein (non-HDL) cholesterol. Background: Evidence from controlled trials encourages the intake of dietary pulses (beans, chickpeas, lentils and peas) as a method of improving dyslipidemia, but heart health guidelines have stopped short of ascribing specific benefits to this type of intervention or have graded the beneficial evidence as low. We conducted a systematic review and metaanalysis of randomized controlled trials (RCTs) to assess the effect of dietary pulse intake on established therapeutic lipid targets for cardiovascular risk reduction.

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“…The energy-restricted period resulted in an expected and marked improvement of blood lipids, blood pressure, and hsCRP as a marker for inflammation. 23 Caloric restriction is known to be a strong activator of protective metabolic pathways, thereby leading to lower blood pressure, improved blood lipids, and reduced inflammatory markers, including hsCRP. 24 -28 However, little is known about the effects of subsequent non-energy-restricted diets varying in protein content and glycemic index on these end points.…”

Section: Discussionmentioning

confidence: 99%

Effects of Weight Loss and Long-Term Weight Maintenance With Diets Varying in Protein and Glycemic Index on Cardiovascular Risk Factors

et al. 2011

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on behalf of DiOGenes Background-We sought to separately examine the effects of either weight loss or diets varying in protein content and glycemic index without further changes in body weight on cardiovascular risk factors within the Diet, Obesity, and Genes study (DiOGenes). Methods and Results-DiOGenes is a pan-European controlled dietary intervention study in 932 overweight adults who first lost body weight on an 8-week low-calorie diet and were then randomized to 1 of 5 ad libitum diets for 26 weeks. The diets were either high or low protein or high or low glycemic index in 4 combinations or control. Weight loss (Ϫ11.23 kg; 95% confidence interval, Ϫ11.54 to Ϫ10.92; PϽ0.001) reduced high-sensitivity C-reactive protein (Ϫ1.15 mg/L; 95% confidence interval, Ϫ1.30 to Ϫ0.41; PϽ0.001), low-and high-density lipoprotein cholesterol, triglycerides, and blood pressure. During the 26-week weight maintenance period in the intention-to-treat analysis, the further decrease of high-sensitivity C-reactive protein blood levels was Ϫ0.46 mg/L greater (95% confidence interval, Ϫ0.79 to Ϫ0.13) in the groups assigned to low-glycemic-index diets than in those on high-glycemic-index diets (PϽ0.001).Groups on low-protein diets achieved a Ϫ0.25 mg/L greater reduction in high-sensitivity C-reactive protein (95% confidence interval, Ϫ0.59 to Ϫ0.17) than those on high-protein diets (PϽ0.001), whereas lipid profiles and blood pressure were not differently affected. Conclusions-This large-scale intervention study clearly separates weight loss from dietary composition-related effects.Low-glycemic-index carbohydrates and, to a lesser extent, low-protein intake may specifically reduce low-grade inflammation and associated comorbidities in overweight/obese adults. Clinical Trial Registration-http://www.clinicaltrials.gov. Unique identifier: NCT00390637.

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A legume-based hypocaloric diet reduces proinflammatory status and improves metabolic features in overweight/obese subjects

Cited by 173 publications

References 38 publications

The role of dietary fatty acid intake in inflammatory gene expression: a critical review

The role of dietary fatty acid intake in inflammatory gene expression: a critical review

Effect of dietary pulse intake on established therapeutic lipid targets for cardiovascular risk reduction: a systematic review and meta-analysis of randomized controlled trials

Effects of Weight Loss and Long-Term Weight Maintenance With Diets Varying in Protein and Glycemic Index on Cardiovascular Risk Factors

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