A lazaroid mitigates postresuscitation myocardial dysfunction

Wang, Jinglan; Weil, Max Harry; Kamohara, Takashi; Tang, Wanchun; Sun, Shijie; Klouche, Kada; Bisera, Joe

doi:10.1097/01.ccm.0000109776.56410.f1

Cited by 9 publications

(3 citation statements)

References 45 publications

(57 reference statements)

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“…100 Zhang et al 25 demonstrated that by inhibiting nitric oxide production with nitric oxide synthase (NOS) inhibitor during a myocardial ischemia-reperfusion sequence, coronary sinus free radical concentration was significantly diminished and accumulation of the peroxynitration product was abolished. Administration of 21-aminosteroids (lazaroids) during CPR has contributed to the improvement of postresuscitation function and better neurologically normal survival.…”

Section: Free Radical Inhibitorsmentioning

confidence: 99%

The Resuscitation Outcome

El‐Menyar

2005

Chest

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Section: Free Radical Inhibitorsmentioning

confidence: 99%

The Resuscitation Outcome

El‐Menyar

2005

Chest

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“…Ischemia, reperfusion injury, inflammation, and related cytokines, catecholamines, microvascular injury, and defibrillation individually or in combination cause postresuscitation myocardial failure [12–14]. …”

Section: Introductionmentioning

confidence: 99%

Ventricular Fibrillation-Induced Cardiac Arrest Results in Regional Cardiac Injury Preferentially in Left Anterior Descending Coronary Artery Territory in Piglet Model

Venkata

Forder

Clark

et al. 2016

BioMed Research International

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Objective. Decreased cardiac function after resuscitation from cardiac arrest (CA) results from global ischemia of the myocardium. In the evolution of postarrest myocardial dysfunction, preferential involvement of any coronary arterial territory is not known. We hypothesized that there is no preferential involvement of any coronary artery during electrical induced ventricular fibrillation (VF) in piglet model. Design. Prospective, randomized controlled study. Methods. 12 piglets were randomized to baseline and electrical induced VF. After 5 min, the animals were resuscitated according to AHA PALS guidelines. After return of spontaneous circulation (ROSC), animals were observed for an additional 4 hours prior to cardiac MRI. Data (mean ± SD) was analyzed using unpaired t-test; p value ≤ 0.05 was considered statistically significant. Results. Segmental wall motion (mm; baseline versus postarrest group) in segment 7 (left anterior descending (LAD)) was 4.68 ± 0.54 versus 3.31 ± 0.64, p = 0.0026. In segment 13, it was 3.82 ± 0.96 versus 2.58 ± 0.82, p = 0.02. In segment 14, it was 2.42 ± 0.44 versus 1.29 ± 0.99, p = 0.028. Conclusion. Postarrest myocardial dysfunction resulted in segmental wall motion defects in the LAD territory. There were no perfusion defects in the involved segments.

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“…These compounds have been shown, in addition to other therapeutic actions, to improve renal and intestinal blood flow [7,8] in septic shock, and myocardial function in ischemia-reperfusion injury [9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%