1998
DOI: 10.1523/jneurosci.18-22-09453.1998
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A Lateralized Deficit in Morphine Antinociception after Unilateral Inactivation of the Central Amygdala

Abstract: The amygdala is a forebrain region that is receiving increasing attention as a modulator of pain sensation. The amygdala contributes to antinociception elicited by both psychological factors (e.g., fear) and exogenous opioid agonists. Unlike the midbrain periaqueductal gray matter (PAG) or rostral ventromedial medulla, the amygdala is a pain-modulating region that has clear bilateral representation in the brain, making it possible to determine whether pain-modulating effects of this region are lateralized with… Show more

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Cited by 124 publications
(85 citation statements)
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“…During the formalin experiments, acute formalin-induced nociceptive behaviors were quantified on the conditioning days. A trained rater scored formalin-induced nociceptive behaviors simultaneously using both the rating scale and flinch frequency methods (25). Scoring was carried out over the entire duration of the conditioning session (50 min) by using time bins of 5 min each.…”
Section: Conditioning Days (Days 2-5)mentioning
confidence: 99%
“…During the formalin experiments, acute formalin-induced nociceptive behaviors were quantified on the conditioning days. A trained rater scored formalin-induced nociceptive behaviors simultaneously using both the rating scale and flinch frequency methods (25). Scoring was carried out over the entire duration of the conditioning session (50 min) by using time bins of 5 min each.…”
Section: Conditioning Days (Days 2-5)mentioning
confidence: 99%
“…Bernard and colleagues (1989Bernard and colleagues ( ,1990Bernard and colleagues ( ,1996 have demonstrated a spino(trigemino)pontoamygdaloid pathway that may be involved with the affective-motivational dimension of pain. Conversely, anatomical and electrophysiological studies indicate the existence of an efferent pathway originating in the amygdala, synapsing within the periaquaductal gray and continuing on to the spinal cord dorsal horn that modulates pain (Hopkins and Holstege 1978;Krettek and Price 1978;Beitz 1982;Watson et al, 1983;Zhang et al, 1991;Bernard et al, 1996;Manning 1998). In addition, the basal ganglia receives nociceptive information through several sources including the amygdala, cingulate cortex, prefrontal cortex and the habenula (Ma and Han, 1991;Cenci et al, 1992;Ma et al, 1992;Chudler and Dong, 1995).…”
Section: Paraventricular Nucleus Of the Hypothalamus-previous Researcmentioning
confidence: 99%
“…footshock) display conditioned analgesia results in both the expression of fear-related behaviour (e.g. freezing and 22-kiloHertz ultrasonic vocalisations) 10, 49 and robust analgesia -as a consequence of activating the descending inhibitory pain pathway 27,32,37,43 .…”
Section: Introductionmentioning
confidence: 99%