A late recurring and easily forgotten tumor: ovarian granulosa cell tumor

Chen, Yi-Chan; Chang, Liang‐Che; Soong, Ruey-Shyang

doi:10.1186/1477-7819-10-85

Cited by 18 publications

(23 citation statements)

References 10 publications

(14 reference statements)

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“…Prognostically, the 5-year survival rate of patients with stage I or II disease is thought to be 95%, and that of patients with stage III or IV disease is 59% [ 8 ]. However, some patients experience relapse 20 to 30 years after the initial surgery [ 4 , 5 ], and there have been a few reports published on the clinical phenotype of those with rapid progression [ 6 ]. Jozwicki et al .…”

Section: Discussionmentioning

confidence: 99%

“…The clinical outcome for tumors at stages I and II is excellent, whereas those at stages III and IV remains poor [ 3 ]. The 5-year survival rate for GCTs is approximately 80% overall, and some patients experience relapse 20 to 30 years after the initial surgery [ 4 , 5 ]. There are few reports on the clinical phenotype of malignant progression [ 6 ], and no standard therapy has yet been established [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

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Presentation of two patients with malignant granulosa cell tumors, with a review of the literature

et al. 2012

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Granulosa cell tumors (GCTs) of the ovary account for 2 to 5 of ovarian malignancies. We present two patients with malignant ovarian adult GCT. In one patient, a combination of bleomycin, etoposide, and cisplatin was effective after initial surgery for malignant GCT. In the other, an aromatase inhibitor was effective for recurrent malignant GCT. We also review the literature for further management of this tumor. Because GCT of the ovary is rare, it will be necessary to elucidate the clinical phenotype and establish treatment protocols by accumulating and analyzing more patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Presentation of two patients with malignant granulosa cell tumors, with a review of the literature

et al. 2012

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“…9 The propensity towards recurrence of the disease often happens after five years and in up to 25% of patients. 10,11 Recurrent GCT has been known to present after 37 years after initial diagnosis, i.e. when the tumour is nearly 'forgotten' by the patient.…”

Section: Case Reportmentioning

confidence: 99%

“…when the tumour is nearly 'forgotten' by the patient. 10 Hence the importance for extended follow-up needed for these patients cannot be overemphasized. 9 Granulosa cell proliferations simulate small ovarian neoplasm and have been commonly encountered as incidental findings in pregnant women.…”

Section: Case Reportmentioning

confidence: 99%

Granulosa Cell Tumor Of The Ovary – An Incidental Finding During Caesarean Section – A Rare Case Report

Roy

Babu

2015

Kathmandu Univ. Med. J.

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Approximately one-fourth of the ovarian neoplasms and cysts are diagnosed incidentally during caesarean section. The possibility of borderline tumor or cancer should be considered although existence of ovarian malignancy in pregnancy is rare. We report a case of a rare solid malignant tumor of the ovary incidentally found during caesarean section. Intraoperatively, it was thought to be a variant of the common ovarian teratoma. Ovariectomy was done but histopathology revealed it to be granulosa cell tumor. The diagnosis changed the prognosis and future treatment plan drastically. Equipped with this knowledge physicians can be made aware of the existence of this little-known ovarian neoplasm along with its rare association with pregnancy. Also one can better manage, counsel and follow-up the patients after delivery, given the knowledge of the tumours' inevitable malignant potential and its high incidence of recurrence.

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“… 4 Patients often forget or misremember previous medical diagnoses, which makes it difficult for clinicians to make an accurate diagnosis before surgery. 5 Therefore, imaging plays an important role in accurate diagnosis. To our knowledge, there are a limited number of studies that report the imaging of recurrent AGCTs 6 and there are no previous articles that describe the magnetic resonance imaging (MRI) characteristics of recurrent tumors.…”

mentioning

confidence: 99%

Magnetic Resonance Imaging of Recurrent Adult Granulosa Cell Tumor of the Ovary: A Retrospective Analysis of 11 Cases

Matsuki¹,

Numoto²,

Suzuki³

et al. 2020

J Comput Assist Tomogr

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Objective The aim of the study was to characterize magnetic resonance imaging findings in patients with recurrent ovarian adult granulosa cell tumors (AGCTs). Methods Clinical and magnetic resonance imaging manifestations of recurrent AGCTs were evaluated in 11 patients. Results Initial recurrences of AGCT were diagnosed between 13 months and 30 years (mean, 11.3 years). Recurrent tumors were located in the pelvic peritoneum, the abdominal peritoneum, the retroperitoneum, and bone. The number of recurrent tumors varied from 1 to 5. Tumors varied in morphology and all margins were well circumscribed. The internal structures noted were as follows: multilocular cystic and solid and cystic. Furthermore, internal hemorrhage and sponge-like multicystic components were identified. Conclusions Ovarian AGCTs recurred in the pelvic peritoneum, abdominal peritoneum, and the retroperitoneal lymph nodes. Large recurrent AGCTs were commonly well circumscribed, round or lobulated, and multilocular cystic or solid and cystic. Moreover, they frequently included internal hemorrhage and sponge-like multicystic components.

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A late recurring and easily forgotten tumor: ovarian granulosa cell tumor

Cited by 18 publications

References 10 publications

Presentation of two patients with malignant granulosa cell tumors, with a review of the literature

Presentation of two patients with malignant granulosa cell tumors, with a review of the literature

Granulosa Cell Tumor Of The Ovary – An Incidental Finding During Caesarean Section – A Rare Case Report

Magnetic Resonance Imaging of Recurrent Adult Granulosa Cell Tumor of the Ovary: A Retrospective Analysis of 11 Cases

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