A laser ablation millisecond-pulsed glow discharge time-of flight mass spectrometer (LA-GD-TOFMS) for quasi-simultaneous elemental and molecular analysis

Tarik, Mohamed; Günther, Detlef

doi:10.1039/c004879h

Cited by 12 publications

(12 citation statements)

References 45 publications

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“…When compared with the EI mass spectrum of this compound [33], these peaks can be identified as fragments from the analyte. The presence of these fragments in the afterglow, which is mainly characterized by PI, can be generated by the laser ablation processes itself, as discussed in the literature [20]. There, the appearance of organic fragments (benzoic acid, polytetrafluoroethylene, polyvinyl chloride) during ablation of these materials into the afterglow has been shown.…”

Section: Resultsmentioning

confidence: 89%

“…In addition, Majidi et al [16] showed the possibility of performing the chemical speciation of volatile compounds using a μs-pulsed GD-TOF system. The analysis of solid samples has been reported by Tarik et al [20] where organic compounds including benzoic acid, vanillic acid, Teflon, and caffeine have been introduced into the GD-TOFMS by laser ablation. In that study elemental ions were observed in the plateau.…”

Section: Introductionmentioning

confidence: 99%

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Tunable fragmentation of organic molecules in laser ablation glow discharge time-of-flight mass spectrometry

Lotito¹,

Günther²

2011

Anal Bioanal Chem

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A DC-pulsed glow discharge (GD) has distinct temporal regimes which are characterized by "softer" or "harder" ionization of analytes introduced into the discharge. It is thus possible to obtain both molecular weight and structural fragment information from the same spectra. In order to extend the capabilities of this technique a laser ablation (LA) sampling system was coupled to a DC-pulsed GD and to a time-of-flight (TOF) mass spectrometer (MS) for characterizing organic samples such as oleic acid, reserpine, two different peptides, and a polymer. Both hard and soft ionization regimes were studied. These LAGD-TOFMS results were compared to matrix-assisted laser desorption ionization (MALDI) spectra using the same compounds (i.e., analytes, concentration, and matrix). It was found that LAGD offers tunable ionization and provides a reduced matrix dependence. However, the sensitivity achieved by the prototype LAGD-TOFMS was significantly lower when compared with commercially available MALDI-TOFMS instrumentation. Since LAGD-TOFMS is rather new, some technical details to increase its sensitivity are discussed.

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Section: Resultsmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Tunable fragmentation of organic molecules in laser ablation glow discharge time-of-flight mass spectrometry

Lotito¹,

Günther²

2011

Anal Bioanal Chem

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“…Laser ablates the sample and GD ionizes the ablated aerosol. 219,220 4.5. X-ray fluorescence spectrometry X-ray fluorescence spectrometry (XRF) can be considered as a quantitative and qualitative analytical tool that can fulfil GAC principles.…”

Section: Glow Discharge Sourcesmentioning

confidence: 99%

Green chemistry in analytical atomic spectrometry: a review

Bendicho

Lavilla

Pena‐Pereira

et al. 2012

J. Anal. At. Spectrom.

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“…Furthermore, all doped elements to the samples were successfully identified in the collected LA-GD spectra with limits of detection in the mg g À1 range. 54…”

Section: Pulsed Glow Dischargesmentioning

confidence: 99%

Plasma-based mass spectrometry for simultaneous acquisition of elemental and molecular information

Solà-Vázquez

Costa‐Fernández

Pereiro

et al. 2011

Analyst

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Chemical speciation studies are commonly accomplished by resorting to hyphenated analytical techniques, consisting of a powerful chromatographic separation technique coupled to a highly sensitive elemental spectrometric detector. However, in addition to this element-selective information, complementary molecular spectrometric tools are often required for a complete identification of macromolecules. Therefore, there is an increased research effort focused towards the development of integrated instruments to carry out the complete chemical speciation within a sample using a single instrument. An outline of recent developments in plasma-based mass spectrometric instrumentation for such comprehensive chemical speciation studies is here presented and their pros and cons detailed. In this context, the use of complementary techniques operating in parallel after splitting to a single chromatographic separation (dual sources) providing simultaneously elemental and molecular information is critically reviewed. Also, instrumental developments involving the use of stationary plasma sources operated in non-traditional modes (e.g. low pressure and low power) are also discussed. Moreover, the capabilities of tunable plasma-based ionization sources (allowing different ionization processes and, so, quasi-simultaneously providing elemental and molecular information with a single instrument) as a relatively simple and cheap approach are revised.

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A laser ablation millisecond-pulsed glow discharge time-of flight mass spectrometer (LA-GD-TOFMS) for quasi-simultaneous elemental and molecular analysis

Cited by 12 publications

References 45 publications

Tunable fragmentation of organic molecules in laser ablation glow discharge time-of-flight mass spectrometry

Tunable fragmentation of organic molecules in laser ablation glow discharge time-of-flight mass spectrometry

Green chemistry in analytical atomic spectrometry: a review

Plasma-based mass spectrometry for simultaneous acquisition of elemental and molecular information

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