A Large Single-Hospital Experience Using Drug Provocation Testing and Rapid Drug Desensitization in Hypersensitivity to Antineoplastic and Biological Agents

Madrigal-Burgaleta, Ricardo; Bernal-Rubio, Lorena; Berges-Gimeno, M P; Carpio-Escalona, L V; Gehlhaar, P; Álvarez-Cuesta, Emilio

doi:10.1016/j.jaip.2018.07.031

Cited by 73 publications

(284 citation statements)

References 42 publications

Supporting

Mentioning

269

Contrasting

Unclassified

Order By: Relevance

“…Nowadays, desensitization is the only treatment for DHRs and is critical especially when patients need first‐line therapy . This procedure allows the safe reintroduction of the drugs independently of the mechanisms .…”

Section: Novel Tools For Managing Dhrmentioning

confidence: 99%

“…23,173 Nowadays, desensitization is the only treatment for DHRs and is critical especially when patients need first-line therapy. 23,[174][175][176][177] This procedure allows the safe reintroduction of the drugs independently of the mechanisms. 178 New nondilution, or 1-solution, desensitization protocols are safe and effective for platinum agents' re-administration.…”

Section: Novel Tool S For Manag Ing Dhrmentioning

confidence: 99%

“…175,179,180 Besides, 12-and 16-step rapid desensitization protocols are effective and safe for biologicals and antineoplastic agents. 15,176,181 Omalizumab has been used as adjuvant helping in the desensitization to oxaliplatin. 182 Premedications have been used to prevent reactions during desensitization.…”

Section: Novel Tool S For Manag Ing Dhrmentioning

confidence: 99%

See 2 more Smart Citations

Recent developments and highlights in drug hypersensitivity

Mayorga

Fernandez

Montañez

et al. 2019

Allergy

View full text Add to dashboard Cite

Drug hypersensitivity reactions (DHRs) are nowadays the third cause of allergy after rhinitis and asthma with a significant increase in prevalence in both adults and paediatric population with new drugs included as culprit. For this, DHRs represent not only a health problem but also a significant financial burden for affected individuals and health systems. Mislabelling DHRs is showing to be a relevant problem for both, false label of drug allergic and false label of nonallergic. All this reinforces the need to improve accurate diagnostic approaches that allow an appropriate management.Moreover, there is a need for training both, nonallergist stakeholders and patients to improve the reaction identification and therefore decrease the mislabelling. The use of allergy cards has shown to be relevant to avoid the induction of DHRs due to the prescription of wrong medication.Recent developments over the last 2 years and highlights about risk factors, diagnostic approaches, mechanisms involved as well as prevention actions, and management have been reviewed. In these papers, it has been outlined the need for correct diagnosis and de-labelling of patients previously false-reported as allergic, which will improve the management and treatment of patients with DHRs. K E Y W O R D Sallergy diagnosis, allergy treatment, basic mechanisms, drug allergy, epidemiology | 2369

show abstract

Section: Novel Tools For Managing Dhrmentioning

confidence: 99%

Section: Novel Tool S For Manag Ing Dhrmentioning

confidence: 99%

See 1 more Smart Citation

Recent developments and highlights in drug hypersensitivity

Mayorga

Fernandez

Montañez

et al. 2019

Allergy

View full text Add to dashboard Cite

show abstract

“…Although the specific treatment of DHRs is avoiding the drug involved and those chemically related, desensitization is nowadays a frequent option . In that sense, rapid drug desensitization is a cost‐effective technique that activates inhibitory mechanisms and permits patients to receive the first‐choice medications to which they are allergic Research needs for DHRs The prevalence and incidence of DHRs Underlying mechanisms of DHRs The most adequate classification of DHRs Definition of endotypes and biomarker identification The most accurate diagnostic approach: i Skin test standardization, sensitivity, specificity, and predictive values for most drugs ii A standardized protocol for performing drug provocation test iii The role of in vitro tests for diagnosis The mechanism of inhibition in rapid drug desensitization procedure …”

Section: Diagnostic Challenges and Regulatory Considerationsmentioning

confidence: 99%

“…148 Although the specific treatment of DHRs is avoiding the drug involved and those chemically related, desensitization is nowadays a frequent option. [149][150][151] In that sense, rapid drug desensitization is a cost-effective technique that activates inhibitory mechanisms and permits patients to receive the first-choice medications to which they are allergic. 149,150 Research needs for DHRs • Could nasal cytology be used in the study of chronic rhinitis, especially for the differential diagnosis of chronic rhinitis?…”

Section: New Approaches To the Diagnosis And Treatment Of Drug Hypementioning

confidence: 99%

Future research trends in understanding the mechanisms underlying allergic diseases for improved patient care

Breiteneder

Diamant

Eiwegger

et al. 2019

Allergy

101

View full text Add to dashboard Cite

This is an open access article under the terms of the Creat ive Commo ns Attri bution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. AbstractThe specialties of allergy and clinical immunology have entered the era of precision medicine with the stratification of diseases into distinct disease subsets, specific diagnoses, and targeted treatment options, including biologicals and small molecules.This article reviews recent developments in research and patient care and future trends in the discipline. The section on basic mechanisms of allergic diseases summarizes the current status and defines research needs in structural biology, type 2 inflammation, immune tolerance, neuroimmune mechanisms, role of the microbiome and diet, environmental factors, and respiratory viral infections. In the section on diagnostic challenges, clinical trials, precision medicine and immune monitoring Zuzana Diamanthttps://orcid.org/0000-0003-0133-0100Thomas Eiwegger https://orcid.org/0000-0002-2914-7829Wytske J. Fokkens https://orcid.org/0000-0003-4852-229X

show abstract

Drug Desensitizations for Chemotherapy: Safety and Efficacy in Preventing Anaphylaxis

Caiado

Castells

2021

Curr Allergy Asthma Rep

View full text Add to dashboard Cite

A Large Single-Hospital Experience Using Drug Provocation Testing and Rapid Drug Desensitization in Hypersensitivity to Antineoplastic and Biological Agents

Cited by 73 publications

References 42 publications

Recent developments and highlights in drug hypersensitivity

Recent developments and highlights in drug hypersensitivity

Future research trends in understanding the mechanisms underlying allergic diseases for improved patient care

Drug Desensitizations for Chemotherapy: Safety and Efficacy in Preventing Anaphylaxis

Contact Info

Product

Resources

About