A large scale expression study associates uc.283-plus lncRNA with pluripotent stem cells and human glioma

Galasso, Marco; Dama, Paola; Previati, Maurizio; Sandhu, Sukhinder K.; Palatini, Jeff; Coppola, Vincenzo; Warner, Sarah; Sana, Maria Elena; Zanella, Riccardo; Abujarour, Ramzey; Desponts, Caroline; Teitell, Michael A.; Garzon, Ramiro; Calin, George A.; Croce, Carlo M.; Volinia, S

doi:10.1186/preaccept-1332028491327360

Cited by 3 publications

(2 citation statements)

References 29 publications

(35 reference statements)

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“…LncRNAs have been implicated in gliomagenesis . For example, H19, a lncRNA that binds to c‐Myc, drives tumor transformation and is upregulated in gliomas .…”

Section: Introductionmentioning

confidence: 99%

Serum HOTAIR and GAS5 levels as predictors of survival in patients with glioblastoma

Shen

Hodges

Song

et al. 2017

Molecular Carcinogenesis

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Circulating long non-coding RNAs (lncRNAs) are a new class of cancer biomarkers.However, their significance in predicting outcomes in glioblastoma patients is unclear.We measured the levels of six known oncogenic lncRNAs-CRNDE, GAS5, H19, HOTAIR, MALAT1, and TUG1 in serum samples from 106 patients with primary glioblastoma and analyzed their association with outcomes. High levels of HOTAIR were associated with decreased probability of 2-year overall survival (adjusted hazard ratio [HR] = 2.04; 95% confidence interval [CI] = 1.08-9.76), and disease-free survival (adjusted HR = 1.82; 95% CI = 1.04-6.17). High levels of GAS5 were associated with increased probability of 2-year overall survival (adjusted HR = 0.44; 95% CI = 0.18-0.99), and disease-free survival (adjusted HR = 0.46; 95% CI = 0.16-0.98). HOTAIR and GAS5 levels could serve as reciprocal prognostic predictors of survival and disease progression in patients with glioblastoma.

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“…LncRNAs have been implicated in gliomagenesis . For example, H19, a lncRNA that binds to c‐Myc, drives tumor transformation and is upregulated in gliomas .…”

Section: Introductionmentioning

confidence: 99%

Serum HOTAIR and GAS5 levels as predictors of survival in patients with glioblastoma

Shen

Hodges

Song

et al. 2017

Molecular Carcinogenesis

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show abstract

“…In normal mammalian tissues and organs, approximately 93% of UCRs can be identified by their transcriptional activity, and these transcripts are termed transcribed UCRs (T-UCRs) (Calin et al, 2007). According to previous reports, T-UCRs expression and function are associated with the maintenance of normal life activities and the occurrence and development of various malignant tumors (Scaruffi et al, 2009;Mestdagh et al, 2010;Ferdin et al, 2013;Peng et al, 2013;Galasso et al, 2014;Jiang et al, 2016;Wu et al, 2016). Furthermore, some intragenic T-UCRs are correlated with their host genes and may regulate their splicing and transcription (Mehta et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Long Non-coding RNA T-uc.189 Modulates Neural Progenitor Cell Fate by Regulating Srsf3 During Mouse Cerebral Cortex Development

Zhang

Zhou

et al. 2021

Front. Neurosci.

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Neurogenesis is a complex process that depends on the delicate regulation of spatial and temporal gene expression. In our previous study, we found that transcribed ultra-conserved regions (T-UCRs), a class of long non-coding RNAs that contain UCRs, are expressed in the developing nervous systems of mice, rhesus monkeys, and humans. In this study, we first detected the full-length sequence of T-uc.189, revealing that it was mainly concentrated in the ventricular zone (VZ) and that its expression decreased as the brain matured. Moreover, we demonstrated that knockdown of T-uc.189 inhibited neurogenesis. In addition, we found that T-uc.189 positively regulated the expression of serine-arginine-rich splicing factor 3 (Srsf3). Taken together, our results are the first to demonstrate that T-uc.189 regulates the expression of Srsf3 to maintain normal neurogenesis during cortical development.

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The emerging role of lncRNAs in the regulation of cancer stem cells

et al. 2018

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A large scale expression study associates uc.283-plus lncRNA with pluripotent stem cells and human glioma

Cited by 3 publications

References 29 publications

Serum HOTAIR and GAS5 levels as predictors of survival in patients with glioblastoma

Serum HOTAIR and GAS5 levels as predictors of survival in patients with glioblastoma

Long Non-coding RNA T-uc.189 Modulates Neural Progenitor Cell Fate by Regulating Srsf3 During Mouse Cerebral Cortex Development

The emerging role of lncRNAs in the regulation of cancer stem cells

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