A Large High-Density Lipoprotein Enriched in Apolipoprotein C-I

Kwiterovich, Peter O.; Cockrill, Steven L.; Virgil, Donna G.; Garrett, Elizabeth; Otvos, James D.; Knight-Gibson, Carolyn; Alaupovic, Petar; Forte, Trudy M.; Zhang, Lin; Farwig, Zachlyn N.; Macfarlane, Ronald D.

doi:10.1001/jama.293.15.1891

Cited by 20 publications

(4 citation statements)

References 42 publications

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“…Additionally, there is a paucity of data available on fetal blood lipid concentrations. One study identified lipid profiles that differed in small-for-gestational-age infants compared to normal-weight infants, with increased levels of apo C-I–enriched high-density lipoproteins [ 14 ], however information is still lacking in this area. Maternal lipid concentrations have been correlated with fetal lipid concentrations at birth among women with diabetes, which highlights the importance of the maternal environment on the fetus during pregnancy [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Maternal and fetal blood lipid concentrations during pregnancy differ by maternal body mass index: findings from the ROLO study

Geraghty

Alberdi

O’Sullivan

et al. 2017

BMC Pregnancy Childbirth

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BackgroundPregnancy is a time of altered metabolic functioning and maternal blood lipid profiles change to accommodate the developing fetus. While these changes are physiologically necessary, blood lipids concentrations have been associated with adverse pregnancy outcomes such as gestational diabetes, pregnancy-induced hypertension and high birth weight. As blood lipids are not routinely measured during pregnancy, there is limited information on what is considered normal during pregnancy and in fetal blood.MethodsData from 327 mother-child pairs from the ROLO longitudinal birth cohort study were analysed. Fasting total cholesterol and triglycerides were measured in early and late pregnancy and fetal cord blood. Intervals were calculated using the 2.5th, 50th and 97.5th centile. Data was stratified based on maternal body mass index (BMI) measured during early pregnancy. Differences in blood lipids between BMI categories were explored using ANOVA and infant outcomes of macrosomia and large-for-gestational-age (LGA) were explored using independent student T-tests and binary logistic regression.ResultsAll maternal blood lipid concentrations increased significantly from early to late pregnancy. In early pregnancy, women with a BMI < 25 kg/m2 had lower concentrations of total cholesterol compared to women with a BMI of 25–29.9 kg/m2 (P = 0.02). With triglycerides, women in the obese category (BMI > 30 kg/m2) had higher concentrations than both women in the normal-weight and overweight category in early and late pregnancy (P < 0.001 and P = 0.03, respectively). In late pregnancy, triglyceride concentrations remained elevated in women in the obese category compared to women in the normal-weight category (P = 0.01). Triglyceride concentrations were also elevated in late pregnancy in mothers that then gave birth to infants with macrosomia and LGA (P = 0.01 and P = 0.03, respectively).ConclusionBlood lipid concentrations increase during pregnancy and differ by maternal BMI. These intervals could help to inform the development of references for blood lipid concentrations during pregnancy.Trial registrationROLO Study - ISRCTN54392969. Date of registration: 22/04/2009.

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Section: Introductionmentioning

confidence: 99%

Maternal and fetal blood lipid concentrations during pregnancy differ by maternal body mass index: findings from the ROLO study

Geraghty

Alberdi

O’Sullivan

et al. 2017

BMC Pregnancy Childbirth

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“…In summary, cord samples SGA neonates presented atherogenic lipid profiles and impaired lipoprotein characteristics. 24,26,38 Other studies demonstrated the presence of large HDL-C subclasses enriched in apo-C-I in cord blood. These molecules appeared elevated in infants with lower birth weights and younger gestational ages and with significantly elevated total and large LDL cholesterol and LDL particle number, but lower total and VLDL triglycerides in contrast with SGA neonates.…”

Section: Lipid Profilementioning

confidence: 99%

“…These molecules appeared elevated in infants with lower birth weights and younger gestational ages and with significantly elevated total and large LDL cholesterol and LDL particle number, but lower total and VLDL triglycerides in contrast with SGA neonates. 38 Additionally, infants with a greater positive change in BMI z-score in the first 6 months presented a high proportion of saturated and low proportion of polyunsaturated plasma fatty acids (PUFA) at birth. Also, a tendency for a lower proportion of n-3 long-chain (LCPUFA) in infants with greater BMI z-score changes in the first 6 months was noticed.…”

Section: Lipid Profilementioning

confidence: 99%

Biomarkers of cardiovascular disease risk in the neonatal population

Lianou

Rallis

Baltogianni

et al. 2022

J Dev Orig Health Dis

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The consistently high prevalence of cardiovascular disease (CVD) has urged the need for punctual and effective prevention. Extended research on this specific area has demonstrated the influence of fetal and neonatal periods on the risk of developing CVD in adulthood. Thus, the role of traditional and novel biological markers to the effective screening of CVD among the neonatal population is widely investigated. The objective of the present narrative review is to examine those neonatal biomarkers that may play a role in the development of CVD, to exhibit scientific data that appertain to their association with various perinatal conditions leading to CVD predisposition, and their potential role on prediction and prevention strategies. Multiple biomarkers, traditional and novel, have been mined across the studied literature. Adiposity, insulin resistance, altered lipid profile, inflammation, and endothelial dysfunction seem among the headliners of CVD. Even though various novel molecules have been studied, their clinical utility remains controversial. Therefore, it is quite important for the scientific community to find elements with strong predictive value and practical clinical use.

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“…The transfer of maternal cholesterol to the fetus through the umbilical cord might justify these effects. A previous study reported that low birth weight infants had lower HDL levels compared to their term counterparts [9,10]. There is still controversy over the association between maternal lipid profile and preterm delivery.…”

Section: Introductionmentioning

confidence: 99%

The relationship between lipid profiles in pregnancy and preterm delivery: a systematic review

2018

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Background: High-density lipoprotein (HDL), low-density lipoprotein (LDL), triglyceride (TG), and total cholesterol (TC) are associated with maternal hormonal changes which can lead to pregnancy complications. High lipid levels during pregnancy may be accompanied by an increased risk of spontaneous preterm labor. The purpose of this review was to determine the relationship between lipid profiles in pregnancy and preterm delivery. Methods: A systematic search was performed in PubMed, EMBASE, Web of Science, Scopus, and Science Direct databases to find cross-sectional, case-control, and cohort studies on the associations between lipid profiles in pregnancy and preterm delivery. The search results were limited to papers published during 2000-2018. The quality of the selected studies was assessed based on the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist. Finally, a total of 25 eligible high-quality papers were reviewed. Results: A high maternal TG level in the first trimester of pregnancy was identified as a significant risk factor for preterm delivery. Low TG, HDL-cholesterol (HDL-C) and LDL-cholesterol (LDL-C) levels were uniquely associated with an increased risk of preterm delivery. High TC, TG, and LDL-C levels increased the risk of spontaneous preterm labor. A further association was found between high TG and TC levels and an elevated risk of preterm labor before 34 weeks of gestation. The risk of preterm labor before 34 weeks and during the 34th-37th weeks of gestation increased with increasing TG and TC levels. Moreover, overweight women who had a delivery before 34 weeks exhibited significant increases in TC and LDL concentrations during early pregnancy. Conclusion: Lipid metabolism undergoes complicated changes in pregnancy. Lipid levels (LDL, HDL, TC, and TG) above or below the normal range during pregnancy increase the risk of preterm delivery. Considering the significance of maternal lipid metabolism in the incidence of preterm delivery, lipid profile screening in early pregnancy can largely contribute to the prevention of preterm delivery. Further studies are warranted to meticulously examine the effects of lipid profile on preterm delivery.

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A Large High-Density Lipoprotein Enriched in Apolipoprotein C-I

Cited by 20 publications

References 42 publications

Maternal and fetal blood lipid concentrations during pregnancy differ by maternal body mass index: findings from the ROLO study

Maternal and fetal blood lipid concentrations during pregnancy differ by maternal body mass index: findings from the ROLO study

Biomarkers of cardiovascular disease risk in the neonatal population

The relationship between lipid profiles in pregnancy and preterm delivery: a systematic review

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