A large Great Britain-wide outbreak of STEC O157 phage type 8 linked to handling of raw leeks and potatoes

Launders, Naomi; Locking, M.; Hanson, Mary; Willshaw, G. A.; Charlett, André; Salmon, R. L.; Cowden, John; Adak, Goutam

doi:10.1017/s0950268815001016

Cited by 30 publications

(23 citation statements)

References 30 publications

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“…The largest national outbreak in Great Britain (252 cases) caused by STEC O157 PT8, linked to handling raw leeks and potatoes, was reported in 2011 and led to the highest incidence during the period (Figure 1) ( 23 ). …”

Section: Resultsmentioning

confidence: 99%

Shiga Toxin–ProducingEscherichia coliO157, England and Wales, 1983–2012

Adams¹,

Byrne²,

Smith³

et al. 2016

Emerg. Infect. Dis.

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Section: Resultsmentioning

confidence: 99%

Shiga Toxin–ProducingEscherichia coliO157, England and Wales, 1983–2012

Adams¹,

Byrne²,

Smith³

et al. 2016

Emerg. Infect. Dis.

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“…In up to 10% of STEC infections hemolytic-uremic syndrome (HUS) may develop, making STEC the main cause of acute renal failure in children [ 1 ]. Humans can contract STEC infection through consumption of food items contaminated by the animal reservoir such as undercooked beef, raw milk, or raw vegetables, through contact with animals or an environment contaminated by colonized animals, or through person-to-person contact in particular in nurseries or within families [ 1 – 6 ]. STEC serogroup O157 infection has been best described, with cattle as the main reservoir among several other mammals and birds [ 7 – 9 ].…”

Section: Introductionmentioning

confidence: 99%

Emerging Shiga-toxin-producing Escherichia coli serogroup O80 associated hemolytic and uremic syndrome in France, 2013-2016: Differences with other serogroups

et al. 2018

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To generate hypotheses on possible sources of Shiga toxin-producing Escherichia coli (STEC) serogroup O80 associated hemolytic-uremic syndrome (HUS), we explored differences in factors associated with STEC O80 associated HUS, compared with STEC O157 or STEC of other serogroups, in France during 2013–16. STEC was isolated from 153/521 (30%) reported HUS cases: 45 serogroup O80, 46 O157 and 62 other serogroups. Median ages were 1.1 years, 4.0 years and 1.8 years, respectively. O80 infected patients were less likely to report ground beef consumption (aOR [adjusted Odds Ratio] 0.14 95% CI [Confidence Interval] 0.02–0.80) or previous contact with a person with diarrhea or HUS (aOR 0.13 95%CI 0.02–0.78) than patients infected with STEC O157. They were also less likely to report previous contact with a person presenting with diarrhea/HUS than patients infected with other serogroups (aOR 0.13 95%CI 0.02–0.78). STEC O80 spread all over France among young children less exposed to known risk factors of O157 or other STEC infections, suggesting the existence of different reservoirs and transmission patterns.

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“…In England over the last 10 years, there has been an increase in reports of STEC O157:H7 outbreaks associated with raw vegetables or salad leaves [4][5][6][7].…”

Section: Discussionmentioning

confidence: 99%

An outbreak of Shiga toxin-producing Escherichia coli O157:H7 associated with contaminated salad leaves: epidemiological, genomic and food trace back investigations

et al. 2017

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In August 2015, Public Health England detected an outbreak of Shiga toxin-producing Escherichia coli (STEC) serotype O157:H7 caused by contaminated salad leaves in a mixed leaf prepacked salad product from a national retailer. The implicated leaves were cultivated at five different farms and the zoonotic source of the outbreak strain was not determined. In March 2016, additional isolates from new cases were identified that shared a recent common ancestor with the outbreak strain. A case-case study involving the cases identified in 2016 revealed that ovine exposures were associated with illness (n = 16; AOR 8·24; 95% CI 1·55-39·74). By mapping the recent movement of sheep and lambs across the United Kingdom, epidemiological links were established between the cases reporting ovine exposures. Given the close phylogenetic relationship between the outbreak strain and the isolates from cases with ovine exposures, it is plausible that ovine faeces may have contaminated the salad leaves via untreated irrigation water or run-off from fields nearby. Timely and targeted veterinary and environmental sampling should be considered during foodborne outbreaks of STEC, particularly where ready to eat vegetables and salads are implicated.

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A large Great Britain-wide outbreak of STEC O157 phage type 8 linked to handling of raw leeks and potatoes

Cited by 30 publications

References 30 publications

Shiga Toxin–ProducingEscherichia coliO157, England and Wales, 1983–2012

Shiga Toxin–ProducingEscherichia coliO157, England and Wales, 1983–2012

Emerging Shiga-toxin-producing Escherichia coli serogroup O80 associated hemolytic and uremic syndrome in France, 2013-2016: Differences with other serogroups

An outbreak of Shiga toxin-producing Escherichia coli O157:H7 associated with contaminated salad leaves: epidemiological, genomic and food trace back investigations

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