A large giant cell tumor of the larynx: Case report and review of the literature

Abstract

BackgroundGiant cell tumors (GCTs) are typically found in the metaphyseal-epiphyseal area of long bones but can also occur in the head and neck region. GCT of the larynx is a rare entity with only 42 reported cases in the international literature. Furthermore, to the best of our knowledge this is the largest laryngeal GCT reported in the literature to date. GCT of the larynx can present with dysphonia, dyspnea, and/or dysphagia and should be considered in the differential diagnosis of a neck mass.Case presentationThis case report describes a giant cell tumor of the left thyroid cartilage in a 30-year-old man who initially presented with dysphonia and dysphagia. Computed tomography (CT) revealed a 5 × 5.7 cm mass centered on the left thyroid cartilage, which was further diagnosed by histopathology as giant cell tumour by open biopsy. The patient was counselled on treatment options and it was decided to proceed with a surgical approach. The patient consented to and successfully underwent a total laryngectomy (TL). Currently the patient has no evidence of disease at 13 months follow-up, has an optimal prosthetic voice, and is able to tolerate all textures of foods.ConclusionGCTs of the larynx have a good prognosis and can be treated successfully through complete resection of the tumor, negating the need for adjunctive therapy such as radiation, chemo or denosumab therapy.

Fine needle aspiration of giant cell tumor involving thyroid gland: A case report of an unprecedented entity

“…The first case of laryngeal GCT was reported by Wessely in 1940 Based on literature search, including our case, no more than 50 cases of laryngeal GCT have been reported. The most common location of laryngeal GCT is the thyroid cartilage, followed by the cricoid and the epiglottic cartilage . It is very difficult and even impossible to get correct diagnosis by sonography .…”

“…The most common location of laryngeal GCT is the thyroid cartilage, followed by the cricoid and the epiglottic cartilage . It is very difficult and even impossible to get correct diagnosis by sonography . In some cases, FNA might be performed before operation.…”

Unusual Expansive Mass in the Thyroid Cartilage

“…Giant cell tumor of the larynx is an uncommon entity with 42 cases reported in the literature, of which 32 involved the thyroid cartilage [1]. This tumor is usually benign but can be locally aggressive, recur (25% of cases), and occasionally produce pulmonary metastasis There is no consensus regarding the management, although surgical excision, ranging from local excision to total laryngectomy is the most frequently employed treatment with excellent outcomes.…”

“…GCTL is typically found in the epiphysis of the long bones of female patients in the third decade. In the head and neck area, it usually occurs in the sphenoid, temporal and ethmoid bones, and rarely presents How to cite this paper: Roldán-Fidalgo, A., Secades, J.R., Ibarra, J. and Sarasibar, H. larynx involvement [1]. The thyroid cartilage is the most frequently affected laryngeal structure (21.6%), followed by the cricoid cartilage (9.26%), the epiglottis (2.6%) and soft tissues of the larynx (2.6%) [2].…”

Laryngeal giant cell tumour presenting as a tongue base lesion causing severe dysphagia

“…A giant cell tumour (GCT) is a rare neoplasm of the larynx. Only 43 cases have been reported to date 1 . GCTs usually involve the long bones 2, 3, 4.…”