2023
DOI: 10.3390/jof9020135
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A Landscape of the Genomic Structure of Cryptococcus neoformans in Colombian Isolates

Abstract: Cryptococcus neoformans species complexes are recognized as environmental fungi responsible for lethal meningoencephalitis in immunocompromised individuals. Despite the vast knowledge about the epidemiology and genetic diversity of this fungus in different regions of the world, more studies are necessary to comprehend the genomic profiles across South America, including Colombia, considered to be the second country with the highest number of Cryptococcosis. Here, we sequenced and analyzed the genomic architect… Show more

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“…There have been numerous reports of the utility of WGS in the investigation of genomic diversity and population studies of both Cryptococcus neoformans and Cryptococcus gattii, with clear delineation of reference genomes and the establishment of WGS findings with genetic cryptococcal genotypes established through MLST. However, these have mainly been studied in the context of sporadic infection or community outbreaks of C. gattii [180][181][182][183]. There have been rare reports of the nosocomial transmission of Cryptococcus spp.…”
Section: Cryptococcus Speciesmentioning
confidence: 99%
“…There have been numerous reports of the utility of WGS in the investigation of genomic diversity and population studies of both Cryptococcus neoformans and Cryptococcus gattii, with clear delineation of reference genomes and the establishment of WGS findings with genetic cryptococcal genotypes established through MLST. However, these have mainly been studied in the context of sporadic infection or community outbreaks of C. gattii [180][181][182][183]. There have been rare reports of the nosocomial transmission of Cryptococcus spp.…”
Section: Cryptococcus Speciesmentioning
confidence: 99%