A land-use regression model for estimating microenvironmental diesel exposure given multiple addresses from birth through childhood

Ryan, Patrick; LeMasters, Grace K.; Levin, Linda; Burkle, Jeff; Biswas, Pratim; Hu, Shaohua; Grinshpun, Sergey A.; Reponen, Tiina

doi:10.1016/j.scitotenv.2008.05.051

Cited by 85 publications

(87 citation statements)

References 24 publications

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“…We also assessed salivary cotinine; exposure to carbon attributable to traffic (ECAT), which was used as a marker of traffic-related air pollution (32,33); asthma and atopic history; and season of admission. Patient race was defined according to caregiver report: white/ Caucasian; black/African American; Asian/ Oriental; or Pacific Islander, American Indian, or Alaskan Native; or other.…”

Section: Outcome and Predictorsmentioning

confidence: 99%

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Allergen Sensitization Profiles in a Population-Based Cohort of Children Hospitalized for Asthma

Beck¹,

Huang

Kercsmar

et al. 2015

Annals ATS

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Rationale: Allergen sensitization is associated with asthma morbidity. A better understanding of allergen sensitization patterns among children hospitalized for asthma could help clinicians tailor care more effectively. To our knowledge, however, sensitization profiles among children hospitalized for asthma are unknown.Objectives: We sought to describe allergen sensitization profiles and the distribution of self-reported in-home exposures among children hospitalized for asthma. We also sought to assess how sensitization profiles varied by sociodemographic and clinical factors.Methods: This population-based cohort study includes data for 478 children, aged 4-16 years, hospitalized for an asthma exacerbation. Predictors included child age, race, sex, insurance status, reported income, salivary cotinine, exposure to traffic-related air pollution, asthma and atopic history, and season of admission. Outcomes included serum IgE specific to Alternaria alternata/A. tenuis, Aspergillus fumigatus, American cockroach, mouse epithelium, dust mite (Dermatophagoides pteronyssinus and farinae), cat dander, and dog dander (deemed sensitive if IgE > 0.35). Self-reported adverse exposures included mold/mildew, water leaks, cockroaches, rodents, and cracks or holes in the walls or ceiling. Presence of carpeting and furry pets was also assessed.Measurements and Main Results: More than 50% of included patients were sensitized to each of Alternaria, Aspergillus, dust mite, cat dander, and dog dander; 28% were sensitized to cockroach and 18% to mouse. Roughly 68% were sensitized to three or more allergens with evidence of clustering. African American children, compared with white children, were more likely to be sensitized to Alternaria, Aspergillus, cockroach, and dust mite (all P , 0.01). White children were more likely to be sensitized to mouse, cat, and dog (all P , 0.01). Lower income was associated with cockroach sensitization whereas higher income was associated with dog and cat sensitization (all P , 0.01). Atopic history was associated with sensitization to three or more allergens (P , 0.01). Although 42% reported exposure to at least one adverse in-home exposure (and 72% to carpet, 51% to furry pets), only weak relationships were seen between reported exposures and sensitizations.Conclusions: Most children admitted to the hospital for asthma exacerbations are sensitized to multiple indoor allergens. Atopy on the inpatient unit serves as a potential target for improvement in chronic asthma management.

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Section: Outcome and Predictorsmentioning

confidence: 99%

“…Cotinine levels were collected via salivary sampling during the admission and defined as above or below the level of detection (34). ECAT was estimated with a land-use regression model using the home address at the time of admission (32,33). It was dichotomized at the sample median.…”

Section: Outcome and Predictorsmentioning

confidence: 99%

Allergen Sensitization Profiles in a Population-Based Cohort of Children Hospitalized for Asthma

Beck¹,

Huang

Kercsmar

et al. 2015

Annals ATS

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“…Each participating child's average daily exposure to traffic-related particles was calculated using a land-use regression model as described in Ryan and colleagues (38). Ambient air sampling was conducted at a total of 27 sampling sites in the greater Cincinnati area from December 2001 through December 2006.…”

Section: Traffic-related Particle Exposurementioning

confidence: 99%

“…Regression models were developed to relate this marker of traffic-related particles measured at the 27 sampling sites with land-use and traffic variables. The final land-use regression model had an R 2 equal to 0.73 and contained independent variables related to elevation, truck intensity within 300 m, length of bus routes within 300 m, and wind direction (38).…”

Section: Traffic-related Particle Exposurementioning

confidence: 99%

Exposure to Traffic-related Particles and Endotoxin during Infancy Is Associated with Wheezing at Age 3 Years

Ryan¹,

Bernstein²,

Lockey³

et al. 2009

Am J Respir Crit Care Med

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106

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Rationale: Murine models demonstrate a synergistic production of reactive oxygen species on coexposure to diesel exhaust particles and endotoxin. Objectives: It was hypothesized that coexposure to traffic-related particles and endotoxin would have an additive effect on persistent wheezing during early childhood. Methods: Persistent wheezing at age 36 months was assessed in the Cincinnati Childhood Allergy and Air Pollution Study, a high-risk birth cohort. A time-weighted average exposure to traffic-related particles was determined by applying a land-use regression model to the homes, day cares, and other locations where children spent time from birth through age 36 months. Indoor levels of endotoxin were measured from dust samples collected before age 12 months. The relationship between dichotomized (,/>75th percentile) trafficrelated particle and endotoxin exposure and persistent wheezing, controlling for potential covariates, was examined. Measurements and Main Results: Persistent wheezing at age 36 months was significantly associated with exposure to increased levels of traffic-related particles before age 12 months (OR 5 1.75; 95% confidence interval, 1.07-2.87). Coexposure to endotoxin had a synergistic effect with traffic exposure on persistent wheeze (OR 5 5.85; 95% confidence interval, 1.89-18.13) after adjustment for significant covariates. Conclusions:The association between traffic-related particle exposure and persistent wheezing at age 36 months is modified by exposure to endotoxin. This finding supports prior toxicological studies demonstrating a synergistic production of reactive oxygen species after coexposure to diesel exhaust particles and endotoxin. The effect of early versus later exposure to traffic-related particles, however, remains to be studied because of the high correlation between exposure throughout the first 3 years of life.

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“…1) (Ryan et al, 2008;Sparks et al, 2013). The wind index is a rescaling of the angle between two vectors: from the nearest major traffic source to the site and predominant wind direction to a scale of zero to one.…”

Section: Wind Indexmentioning

confidence: 99%

Traffic Particles in Ambient Air of a Major US Urban Area: Has Anything Changed over a Decade?

Grinshpun

Yermakov

Reponen

et al. 2014

Aerosol Air Qual. Res.

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Few studies have addressed the potential changes in particulate matter (PM) exposure occurring in major metropolitan areas over substantial time periods, e.g., 5 or 10 years. The present study examined changes in the PM 2.5 concentration and elemental composition between two monitoring campaigns carried out in 2002-2005 and 2010-2011 within the Greater Cincinnati area (USA). This area is recognized for high volume of diesel truck traffic (about 10 million trucks annually on regional freeways). The 24-hour filter samples were collected at four sites. General linear models were used to examine differences between the two data sets for elemental carbon (EC), organic carbon (OC), and EC/OC. The comparison was extended to the concentrations of PM 2.5 and its relevant elemental constituents. At one site, which was previously identified as a particularly hot spot for traffic/diesel air pollution, the concentrations of most traffic related elements as well as EC and EC/OC ratio significantly decreased (p < 0.05) between the two campaigns. No significant differences between carbon data generated in the two campaigns were observed at the other three monitoring stations. These findings did not depend on whether the comparison model accounted for wind speed and direction. The EC/OC determined in the recent campaign across all sites showed no significant differences between the Summer and Fall data but Winter values were significantly lower. The site with the highest traffic influence revealed no significant seasonal difference in PM 2.5 but essentially all relevant elements showed significant seasonal variations between the Fall (higher) and Winter (lower). The findings suggest that air quality and engine exhaust control policies implemented between 2005 and 2010 have not produced significant changes in metropolitan traffic air pollution levels. However, the decreasing trends in PM 2.5 , Ti, V, Mn, Fe, Zn, Br, and Pb, EC, OC, and EC/OC may become sustainable over a longer time.

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A land-use regression model for estimating microenvironmental diesel exposure given multiple addresses from birth through childhood

Cited by 85 publications

References 24 publications

Allergen Sensitization Profiles in a Population-Based Cohort of Children Hospitalized for Asthma

Allergen Sensitization Profiles in a Population-Based Cohort of Children Hospitalized for Asthma

Exposure to Traffic-related Particles and Endotoxin during Infancy Is Associated with Wheezing at Age 3 Years

Traffic Particles in Ambient Air of a Major US Urban Area: Has Anything Changed over a Decade?

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