A laboratory-scale annular continuous flow reactor for UV photochemistry using excimer lamps for discrete wavelength excitation and its use in a wavelength study of a photodecarboxlyative cyclisation

DeLaney, Erica N.; Lee, Darren S.; Elliott, Luke D.; Jin, Jing; Booker‐Milburn, Kevin I.; Poliakoff, Martyn; George, Michael W.

doi:10.1039/c6gc02888h

Cited by 27 publications

(23 citation statements)

References 65 publications

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“…As with thermal reactors, options for photochemical reactors have bifurcated into home-built and commercial platforms, essentially light-transparent chips or coil reactors. [89][90][91] Photochemistry's true niche is the formation of synthetically inaccessible molecules. Challenging through standard chemical transformations, the utilization of Scheme 1 Telescoped scheme for the continuous flow production of Ciprofloxacin.…”

Section: Reactor Selectionmentioning

confidence: 99%

Continuous manufacturing – the Green Chemistry promise?

2019

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Section: Reactor Selectionmentioning

confidence: 99%

Continuous manufacturing – the Green Chemistry promise?

2019

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“…In the first example DeLaney et al . describe an annular continuous flow reactor combined with a set of excimer lamp light sources for the irradiation with defined wavelengths (KrCl: 222 nm; XeBr: 282 nm; XeCl: 308) . The reactor itself consists of a stainless steel cooling finger (o.d.…”

Section: Reactor Concepts For Flow Photochemistrymentioning

confidence: 99%

“… Photodecarboxylative cyclisation of potassium N ‐phthalimido‐butanoate 6 with UV light in continuous flow …”

Section: Reactor Concepts For Flow Photochemistrymentioning

confidence: 99%

Reactor Technology Concepts for Flow Photochemistry

Rehm

2019

ChemPhotoChem

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Synthetic organic photochemistry has been intensively carried out in the 20th century and paved the way to the preparation of complex organic molecules, which were not yet accessible via thermal chemistry. Several photochemical synthesis routes have found their way into industrial applications for the production of everyday commodities, but photochemistry was still underutilized until recently as a synthesis method in organic chemistry. With the advent of novel photocatalytic and photophysical concepts for the use of high power visible light, the research field of synthetic organic photochemistry has evolved to become a vivid and highly recognized technique in the last years. Fortunately, continuous flow technology has also become an increasingly accepted tool and has proved to be an excellent key player for the advancement of photochemistry in academic and industrial research settings. This Review provides an overview on the recent developments of continuous flow photoreactors and their application to photochemical syntheses under mild and defined process conditions.

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“…50 mL) was placed between the second and third reactor module to remove excess of acid after the dehydration step. A similar approach was described by DeLaney et al for the removal of base [21]. Heating was achieved in the third step by submerging the capillary coil in a water bath.…”

Section: Flow Reactor Designmentioning

confidence: 99%

Continuous Flow Photochemical and Thermal Multi-Step Synthesis of Bioactive 3-Arylmethylene-2,3-Dihydro-1H-Isoindolin-1-Ones

2019

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An effective multi-step continuous flow approach towards N-diaminoalkylated 3-arylmethylene-2,3-dihydro-1H-isoindolin-1-ones, including the local anesthetic compound AL-12, has been realized. Compared to the traditional decoupled batch processes, the combined photochemical-thermal-thermal flow setup rapidly provides the desired target compounds in superior yields and significantly shorter reaction times.Abstract: An effective multi-step continuous flow approach towards N-diaminoalkylated 3arylmethylene-2,3-dihydro-1H-isoindolin-1-ones, including the local anesthetic compound AL-12, has been realized. Compared to the traditional decoupled batch processes, the combined photochemical-thermal-thermal flow setup rapidly provides the desired target compounds in superior yields and significantly shorter reaction times.

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A laboratory-scale annular continuous flow reactor for UV photochemistry using excimer lamps for discrete wavelength excitation and its use in a wavelength study of a photodecarboxlyative cyclisation

Abstract: A novel annular flow reactor for UV photochemistry.

Cited by 27 publications

References 65 publications

Continuous manufacturing – the Green Chemistry promise?

Continuous manufacturing – the Green Chemistry promise?

Reactor Technology Concepts for Flow Photochemistry

Continuous Flow Photochemical and Thermal Multi-Step Synthesis of Bioactive 3-Arylmethylene-2,3-Dihydro-1H-Isoindolin-1-Ones

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