A laboratory framework for ongoing optimization of amplification-based genomic surveillance programs
Connie Lam,
Jessica Johnson-Mackinnon,
Kerri Basile
et al.
Abstract:Constantly evolving viral populations affect the specificity of primers and the quality of genomic surveillance. This study presents a framework for the continuous optimization of sequencing efficiency for public health surveillance based on the ongoing evolution of the COVID-19 pandemic. SARS-CoV-2 genomic clustering capacity based on three amplification-based whole genome sequencing schemes was assessed using decreasing thresholds of genome coverage and measured against epidemiologically linked cases. The ov… Show more
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