A label-free ultrasensitive assay of 8-hydroxy-2′-deoxyguanosine in human serum and urine samples via polyaniline deposition and tetrahedral DNA nanostructure

Tetrahedral DNA nanostructures facilitate neural stem cell migration via activating RHOA/ROCK2 signalling pathway

“…DNA materials have shown potential in various biomedical fields, such as anti‐multidrug resistance and disease diagnostics/therapeutics . Different DNA nanostructures maintain various biological effects; among them, one of the most promising nanomaterials is tetrahedral DNA nanostructures (TDNs) . This kind of DNA material has received increased research attention because of its biological safety and simplicity of synthesis .…”

“…Self‐assembled TDNs comprise 4 single‐stranded DNAs (ssDNAs) that are designed based on the principle of base pairing. Therefore, TDNs possess excellent structural stability, mechanical rigidity and modification versatility . Previous studies of TDNs have shown that different cells could internalize TDNs, and then TDNs exerted influence on the cells’ biological behaviours under certain conditions .…”

Rational Design of Framework Nucleic Acids for Bioanalytical Applications

“…To achieve sensitive detection of 8‐OHdG, Fan et al. established an electrochemical biosensor based on an 8‐OHdG‐aptamer‐pendant TDNs (Figure c) . The presence of 8‐OHdG and hemin induce aptamer to form a hemin/G‐quadruplex structure.…”

“…To achieve sensitive detection of 8-OHdG, Fan et al established an electrochemical biosensor based on an 8-OHdG-aptamer-pendant TDNs (Figure 3c). [43] The presence of 8-OHdG and hemin induce aptamer to form a hemin/G-quadruplex structure. The resulting hemin/G-quadruplexes with high catalytic efficiency facilitates the deposition of polyaniline (PANI) on TDN, thereby enhancing electrochemical signal.…”

“…with permission from Elsevier B.V. (c) Tetrahedral DNA nanostructure-based sensors for 8-OHdG analysis. Reproduced from Ref [43]. with permission from Elsevier B.V.…”