A label-free G-quadruplex and ThT mediated fluorescent sensor for detection of Cu2+ from water samples

Label-free liquid crystal-based optical detection of norfloxacin using an aptamer recognition probe in soil and lake water

“…The most compelling explanation for this would be the displacement of ThT as a consequence of a competitive binding of NOX into the G-quadruplex, leading to G-quadruplex dispersal and expulsion of ThT molecules out of the G-quadruplex complex, leading to a substantial decrease in fluorescence intensity. The observed behavior is in keeping with previous reports 48 of similar systems.…”

Promoter G-Quadruplex Binding Styryl Benzothiazolium Derivative for Applications in Ligand Affinity Ranking and as Ethidium Bromide Substitute in Gel Staining

“…Several G-quadruplex binding agents have been discovered in the last three decades mostly comprising aromatic scaffolds. − Among G-quadruplex binding agents, fluorescent compounds capable of having stable interactions with the G-quadruplex have found numerous uses as potentially therapeutic, diagnostic, staining, and sensing agents. − Fluorescent compounds have also found wide applications in serving as reporter probes in displacement assays including the G-quadruplex to rank ligand binding against a nucleic acid host. − Traditionally, ethidium bromide and thiazole orange are used in such applications in nucleic acid-based displacement assays due to the nonspecific affinities of their binding allowing their applicability in varied systems such as duplexes, triplexes, and G-quadruplexes. However, there are certain limitations with both intercalators.…”