A label-free fluorescent aptasensor for detection of kanamycin based on dsDNA-capped mesoporous silica nanoparticles and Rhodamine B

Dehghani, Shahrzad; Danesh, Noor Mohammad; Ramezani, Mohammad; Alibolandi, Mona; Lavaee, Parirokh; Nejabat, Mojgan; Abnous, Khalil; Taghdisi, Seyed Mohammad

doi:10.1016/j.aca.2018.05.003

Cited by 67 publications

(18 citation statements)

References 27 publications

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“…In this context, AIE luminogens-/AIEgens-functionalized MSNs were synthesized by Wang et al through post-grafting two types of tetraphenylethene derivatives on the surface of the mesoporous materials. Under UV irradiation, these chemical sensors emitted strong blue fluorescence and exhibited fast and sensitive responses to 2,4,6-trinitrophenol and 2,4-dinitrophenol through the fluorescence quenching process [150]. Moreover, a system based on functionalized magnetite nanoparticles and MSN, using 2-(2-hydroxyphenyl) benzothiazole as the fluorogenic agent for the selective detection of zinc ion in live cell imaging, was reported by Erami et al It was proven that the presence of the fluorophore in the composite system increased cell viability and zinc ion uptake, with desirable signaling in the normal human kidney epithelial (Hek293) cell line [151].…”

Section: Fluorescent Sensingmentioning

confidence: 99%

Mesoporous Silica Platforms with Potential Applications in Release and Adsorption of Active Agents

et al. 2020

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In recent years, researchers focused their attention on mesoporous silica nanoparticles (MSNs) owing to the considerable advancements of the characterization methods, especially electron microscopy methods, which allowed for a clear visualization of the pore structure and the materials encapsulated within the pores, along with the X-ray diffraction (small angles) methods and specific surface area determination by Brunauer–Emmett–Teller (BET) technique. Mesoporous silica gained important consideration in biomedical applications thanks to its tunable pore size, high surface area, surface functionalization possibility, chemical stability, and pore nature. Specifically, the nature of the pores allows for the encapsulation and release of anti-cancer drugs into tumor tissues, which makes MSN ideal candidates as drug delivery carriers in cancer treatment. Moreover, the inner and outer surfaces of the MSN provide a platform for further functionalization approaches that could enhance the adsorption of the drug within the silica network and the selective targeting and controlled release to the desired site. Additionally, stimuli-responsive mesoporous silica systems are being used as mediators in cancer therapy, and through the release of the therapeutic agents hosted inside the pores under the action of specific triggering factors, it can selectively deliver them into tumor tissues. Another important application of the mesoporous silica nanomaterials is related to its ability to extract different hazardous species from aqueous media, some of these agents being antibiotics, pesticides, or anti-tumor agents. The purpose of this paper is to analyze the methods of MSN synthesis and related characteristics, the available surface functionalization strategies, and the most important applications of MSN in adsorption as well as release studies. Owing to the increasing antibiotic resistance, the need for developing materials for antibiotic removal from wastewaters is important and mesoporous materials already proved remarkable performances in environmental applications, including removal or even degradation of hazardous agents such as antibiotics and pesticides.

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Section: Fluorescent Sensingmentioning

confidence: 99%

Mesoporous Silica Platforms with Potential Applications in Release and Adsorption of Active Agents

et al. 2020

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“…2a1, Fig. 2a2) [35,36]; (2) decorating fluorescent materials on the surface of microspheres ( Fig. 2a3) [37]; (3) decorating an inorganic layer on the surface of quantum dots forming a coreeshell structure or combing an organic functional layer (Fig.…”

Section: Fluorescent Nanoparticlesmentioning

confidence: 99%

Nanomaterial-based fluorescent biosensor for veterinary drug detection in foods

Tao¹,

Peng²,

Liu³

2020

Journal of Food and Drug Analysis

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Veterinary drugs have been widely used in the food industry. Their residues in food products need to be tightly regulated to ensure food safety. In particular, some veterinary drugs are still used illegally, although they have already been banned. Nanomaterials are playing an increasingly important role in analytical chemistry due to their unique properties. Compared to traditional organic dyes and colloidal gold nanoparticle labels, fluorescent nanomaterials appear particularly attractive for the detection of veterinary drug residues. This review summarizes recent advancements of fluorescent biosensors using nanomaterials for the detection of veterinary drug residues in foods. The useful properties of each type of fluorescent nanomaterial are first discussed such as large Stokes shifts, long emission lifetime, and high quantum yields, which are useful for detection in food-related sample matrix. The following target recognition molecules are then reviewed individually including antibodies, aptamers, molecularly imprinted polymers, and metal ion coordination based ligands. Representative bioconjugation and assay methods are discussed for each recognition mechanism. Finally, a few future research directions are outlined in the last section of this review.

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“…The binding of kanamycin to the aptamer dissociated the aptamer from the complementary DNA and triggered the release of Rhodamine B to the solution, causing the increase in FL intensity. The LOD for kanamycin was 7.5 nM [34]. In addition, the kanamycin-aptamer was employed as a template for the preparation of Ag NCs, which had weak FL intensity initially.…”

Section: Turn-on Fluorescent Analysis Strategiesmentioning

confidence: 99%

Recent Advances in Optical Detection of Aminoglycosides

Zhou

Cao

2020

Applied Sciences

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Aminoglycosides (AGs) are broad-spectrum antibiotics used in both human infection and animal medicine. The overuse of AGs causes undesirable residues in food, leading to serious health problems due to food chain accumulation. In recent years, various methods have been developed to determine AGs in food. Among these methods, fluorescent (FL), colorimetric and chemiluminescent (CL) optical methods possess advantages such as their simple instrumentation, low cost, simple operation, feasibility of realizing visualization, and smartphone imaging. This mini-review summarizes optical assays for the detection of AGs in food developed in recent years. The detection principles for different categories are discussed. Then, the amplification techniques for the ultrasensitive detection of AGs are introduced. We also discuss multiplex methods for the simultaneous detection of AGs. Finally, the challenges and future prospects are discussed in the Conclusions and Perspectives section.

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A label-free fluorescent aptasensor for detection of kanamycin based on dsDNA-capped mesoporous silica nanoparticles and Rhodamine B

Cited by 67 publications

References 27 publications

Mesoporous Silica Platforms with Potential Applications in Release and Adsorption of Active Agents

Mesoporous Silica Platforms with Potential Applications in Release and Adsorption of Active Agents

Nanomaterial-based fluorescent biosensor for veterinary drug detection in foods

Recent Advances in Optical Detection of Aminoglycosides

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