A label-free electrochemical immunosensor for the detection of cardiac marker using graphene quantum dots (GQDs)

Tuteja, Satish K.; Chen, Rui; Kukkar, Manil; Song, Chung Kil; Mutreja, Ruchi; Singh, Suman; Paul, A.K.; Lee, Haiwon; Kim, Ki‐Hyun; Deep, Akash; Suri, C. Raman

doi:10.1016/j.bios.2016.07.052

Cited by 141 publications

(68 citation statements)

References 52 publications

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“…Using SWV, they demonstrated a LoD of 0.05 ng mL −1 . Tuteja et al [88] described a label-free immunosensor based on EIS for detection of myoglobin. Graphene quantum dots (GQDs) have been used as an immobilized template on SPE.…”

Section: Discussionmentioning

confidence: 99%

Recent Advances in Electrochemical Immunosensors

Piro

Reisberg

2017

Sensors

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Immunosensors have experienced a very significant growth in recent years, driven by the need for fast, sensitive, portable and easy-to-use devices to detect biomarkers for clinical diagnosis or to monitor organic pollutants in natural or industrial environments. Advances in the field of signal amplification using enzymatic reactions, nanomaterials such as carbon nanotubes, graphene and graphene derivatives, metallic nanoparticles (gold, silver, various oxides or metal complexes), or magnetic beads show how it is possible to improve collection, binding or transduction performances and reach the requirements for realistic clinical diagnostic or environmental control. This review presents these most recent advances; it focuses first on classical electrode substrates, then moves to carbon-based nanostructured ones including carbon nanotubes, graphene and other carbon materials, metal or metal-oxide nanoparticles, magnetic nanoparticles, dendrimers and, to finish, explore the use of ionic liquids. Analytical performances are systematically covered and compared, depending on the detection principle, but also from a chronological perspective, from 2012 to 2016 and early 2017.

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Section: Discussionmentioning

confidence: 99%

Recent Advances in Electrochemical Immunosensors

Piro

Reisberg

2017

Sensors

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“…This modification led to an LOD of 0.5 pg mL −1 . Tuteja and co-workers fabricated a label-free impedimetric electrochemical immunosensor for the sensitive detection of cardiac myoglobin (cMyo) [66], an early indicator of acute myocardial infarction (AMI) [141]. Hydrothermally-synthesized GQDs were laminated on screen-printed electrodes (SPEs) as an immobilized template.…”

Section: Gqd-based Electrochemical Immunosensors For Monitoring Cardimentioning

confidence: 99%

“…Emerging research on GQDs in designing electrochemical immunosensors has been conducted incredibly in the last five years, owing to their attractive features [63,[65][66][67]. Moreover, scientists have zeroed in on the development of such immunosensors for biomedical applications via the usage of (a) biomarkers or pathogens responsible for the respective disease type, (b) highly specific and sensitive immunosensors, and (c) various bioassays.…”

Section: Introductionmentioning

confidence: 99%

Graphene Quantum Dot-Based Electrochemical Immunosensors for Biomedical Applications

Mansuriya

Altıntaş

2019

Materials

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In the area of biomedicine, research for designing electrochemical sensors has evolved over the past decade, since it is crucial to selectively quantify biomarkers or pathogens in clinical samples for the efficacious diagnosis and/or treatment of various diseases. To fulfil the demand of rapid, specific, economic, and easy detection of such biomolecules in ultralow amounts, numerous nanomaterials have been explored to effectively enhance the sensitivity, selectivity, and reproducibility of immunosensors. Graphene quantum dots (GQDs) have garnered tremendous attention in immunosensor development, owing to their special attributes such as large surface area, excellent biocompatibility, quantum confinement, edge effects, and abundant sites for chemical modification. Besides these distinct features, GQDs acquire peroxidase (POD)-mimicking electro-catalytic activity, and hence, they can replace horseradish peroxidase (HRP)-based systems to conduct facile, quick, and inexpensive label-free immunoassays. The chief motive of this review article is to summarize and focus on the recent advances in GQD-based electrochemical immunosensors for the early and rapid detection of cancer, cardiovascular disorders, and pathogenic diseases. Moreover, the underlying principles of electrochemical immunosensing techniques are also highlighted. These GQD immunosensors are ubiquitous in biomedical diagnosis and conducive for miniaturization, encouraging low-cost disease diagnostics in developing nations using point-of-care testing (POCT) and similar allusive techniques.

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“…A label-free immunosensor based on EIS was developed for the sensitive detection of myoglobin using GQDs as a template for the construction of the myoglobin sensor platform [60]. To develop the desired immunosensor, the GQDs-modified electrode was conjugated with highly specific anti-myoglobin antibodies.…”

Section: Myoglobinmentioning

confidence: 99%

Nanomaterials‐based Electrochemical Sensing of Cardiac Biomarkers for Acute Myocardial Infarction: Recent Progress

Nsabimana

Yuan

et al. 2018

Electroanalysis

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The development of the methods for early and accurate diagnosis of acute myocardial infarction are needed to facilitate immediate treatment of patients. One of the ways to achieve that is the detection of cardiac biomarkers for myocardial infarction, such as thrombin, cardiac troponins (I and T), myoglobin, etc. Nanotechnology has played an important role in the development of sensitive and efficient electrochemical sensors for cardiac biomarkers. In this review, we discuss recent progress on nanomaterial‐based electrochemical sensing of various cardiac biomarkers for acute myocardial infarction.

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A label-free electrochemical immunosensor for the detection of cardiac marker using graphene quantum dots (GQDs)

Cited by 141 publications

References 52 publications

Recent Advances in Electrochemical Immunosensors

Recent Advances in Electrochemical Immunosensors

Graphene Quantum Dot-Based Electrochemical Immunosensors for Biomedical Applications

Nanomaterials‐based Electrochemical Sensing of Cardiac Biomarkers for Acute Myocardial Infarction: Recent Progress

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