A Label-free DNA-based Fluorescent Sensor for Cisplatin Detection

Jantarat, Teerapong; Chuaychob, Surachada; Thammakhet‐Buranachai, Chongdee; Thavarungkul, Panote; Kanatharana, Proespichaya; Srisintorn, Wisarut; Buranachai, Chittanon

doi:10.1016/j.snb.2020.128764

Cited by 19 publications

(8 citation statements)

References 60 publications

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“…High‐dense d(GpG) sites on DNA Telo make our DROT an ultrasensitive cisplatin biosensor with ultralow detection limit of 426 × 10 −18 m , which is approximately seven orders of magnitude lower than the recently reported cisplatin sensor. [ 21 ] On the other hand, tailored dsDNA can also serve as unique target for evaluating the distortion‐type gene damage. With future design of DROT, multiple response models might be constructed to detect different kinds of damages including base modification, mismatch, and break.…”

Section: Resultsmentioning

confidence: 99%

An Oligonucleotide‐Distortion‐Responsive Organic Transistor for Platinum‐Drug‐Induced DNA‐Damage Detection

Wang

Shen

et al. 2021

Advanced Materials

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Organic transistor with DNA‐damage evaluation ability can open up novel opportunities for bioelectronic devices. Even though trace amounts of drugs can cause cumulative gene damage in vivo, the extremely low occurrence proportion makes them hardly transduced into detectable electric signals. Here, an ultrasensitive DNA‐damage sensor based on an oligonucleotide‐distortion‐responsive organic transistor (DROT) is reported by creating controllable conformation change of double‐stranded DNA on the surface of organic semiconductors. In combination with interfacial charge redistribution and efficient signal amplification, the DROT provides an ultrasensitive single‐site DNA‐damage response with 20.5 s even upon 1 × 10−12 m cisplatin. The high generalizability of this DROT to three generations of classical platinum drugs and gene‐relevant DNA damage is demonstrated. A biochip is further designed for intelligent damage analysis in complex environments, which holds the potential for high‐throughput biotoxicity evaluation and drug screening in the future.

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Section: Resultsmentioning

confidence: 99%

An Oligonucleotide‐Distortion‐Responsive Organic Transistor for Platinum‐Drug‐Induced DNA‐Damage Detection

Wang

Shen

et al. 2021

Advanced Materials

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“…ThT, a well-known fluorescence probe, has also been widely exploited for detecting metal ions and biomolecules, especially binding with G4. ,,,,,− ,− The fluorescence intensity of ThT is significantly increased due to its binding with G4 derivated from their intercalation, groove-binding, and end stacking, so that ThT has better recognition of G4 than other common dyes (NMM, thiazole orange, crystal violet, SYBR green, ethidium bromide). In 2015, Sugimoto et al employed ThT as a fluorescence probe for monitoring RNA metabolism in vitro and in vivo .…”

Section: Gfs Noncovalently Modified With Extrinsic Fluorogenic Dyesmentioning

confidence: 99%

“…In 2021, Buranachai et al. developed a sensitive fluorescence sensor for the recognition of cisplatin-based G4s and ThT (Figure F) . ThT can attach to the G4, causing fluorescence emission.…”

Section: Gfs Noncovalently Modified With Extrinsic Fluorogenic Dyesmentioning

confidence: 99%

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Recent Developments in G-Quadruplex Binding Ligands and Specific Beacons on Smart Fluorescent Sensor for Targeting Metal Ions and Biological Analytes

et al. 2022

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The G-quadruplex structure is crucial in several biological processes, including DNA replication, transcription, and genomic maintenance. G-quadruplex-based fluorescent probes have recently gained popularity because of their ease of use, low cost, excellent selectivity, and sensitivity. This review summarizes the latest applications of G-quadruplex structures as detectors of genome-wide, enantioselective catalysts, disease therapeutics, promising drug targets, and smart fluorescence probes. In every section, sensing of Gquadruplex and employing G4 for the detection of other analytes were introduced, respectively. Since the discovery of the G-quadruplex structure, several studies have been conducted to investigate its conformations, biological potential, stability, reactivity, selectivity for chemical modification, and optical properties. The formation mechanism and advancements for detecting different metal ions

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“…Nanomaterials are widely used in the development of sensitive and efficient fluorescence sensors due to most of them have unique photoelectric characteristics such as photoelectric stability, adjustable size emission spectrum, long fluorescence lifetime, and multifunctional indication modification. They can be used for some basic substances of human body such as DNA [2], RNA [3] and protein [4], and can also detect the content of some drugs such as cocaine [5] and DOX [6]. At present, many fluorescent biosensors also have certain limitations, such as easy to be interfered by detected substances and some environmental factors.…”

Section: Introductionmentioning

confidence: 99%

Applications of fluorescent biosensors based on quantum dots

Ren,

Zhang

2022

HSET

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In modern analytical sciences, fluorescent biosensors are widely used because of their have high sensitivity, high selectivity and stability. Quantum dots (QDs) are a kind of new semiconductor materials which are popular in recent years, which have been widely used in bioimaging, sensing, drug delivery and photocatalysis. QDs have unique and excellent photoelectric characteristics, and are mainly composed of II-VI period element. Due to its good biocompatibility, high stability, excellent water solubility and easy surface modification, the prepared QDs come from a wide range of sources and are considered to be good fluorescent probes for the development of a diverse of fluorescent biosensors. This research describes the progress of fluorescent biosensors based on QDs in recent years, focusing on the three mechanisms and applications in detection, such as the detection of glucose, uric acid and cell apoptosis. And this research also looks forward to the future development trend of QDs-based fluorescent biosensors.

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A Label-free DNA-based Fluorescent Sensor for Cisplatin Detection

Cited by 19 publications

References 60 publications

An Oligonucleotide‐Distortion‐Responsive Organic Transistor for Platinum‐Drug‐Induced DNA‐Damage Detection

An Oligonucleotide‐Distortion‐Responsive Organic Transistor for Platinum‐Drug‐Induced DNA‐Damage Detection

Recent Developments in G-Quadruplex Binding Ligands and Specific Beacons on Smart Fluorescent Sensor for Targeting Metal Ions and Biological Analytes

Applications of fluorescent biosensors based on quantum dots

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