A label-free biosensor based on localized surface plasmon resonance for diagnosis of tuberculosis

Sun, Wenxia; Yuan, Sheng; Huang, Haowen; Liu, Ning; Tan, Yun‐Hong

doi:10.1016/j.mimet.2017.09.007

Cited by 19 publications

(12 citation statements)

References 20 publications

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“…SPR biosensors are new technologies that are widely used due to their greater sensitivity and simplicity and ability to provide real-time results [138]. This phenomenon was observed for the first time and reported in the pertinent literature by RH Ritchie (1957), who demonstrated that there was a loss of energy when the electrons penetrated metal, giving rise to the concept of "metallic plasmon" for describing fluctuations in the internal density of metal electrons [139].…”

Section: Surface Plasmon Resonance (Spr)-based Optical Biosensorsmentioning

confidence: 97%

Optical Biosensors for Therapeutic Drug Monitoring

et al. 2019

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Therapeutic drug monitoring (TDM) is a fundamental tool when administering drugs that have a limited dosage or high toxicity, which could endanger the lives of patients. To carry out this monitoring, one can use different biological fluids, including blood, plasma, serum, and urine, among others. The help of specialized methodologies for TDM will allow for the pharmacodynamic and pharmacokinetic analysis of drugs and help adjust the dose before or during their administration. Techniques that are more versatile and label free for the rapid quantification of drugs employ biosensors, devices that consist of one element for biological recognition coupled to a signal transducer. Among biosensors are those of the optical biosensor type, which have been used for the quantification of different molecules of clinical interest, such as antibiotics, anticonvulsants, anti-cancer drugs, and heart failure. This review presents an overview of TDM at the global level considering various aspects and clinical applications. In addition, we review the contributions of optical biosensors to TDM.

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Section: Surface Plasmon Resonance (Spr)-based Optical Biosensorsmentioning

confidence: 97%

Optical Biosensors for Therapeutic Drug Monitoring

et al. 2019

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Section: Localised Surface Plasmon Resonance Sensors For Biomedical Dmentioning

confidence: 99%

“…Hence, AgNPs are subjected to functionalisation prior to their application in sensor development [91]. Due to higher stability as well as a superior capability to undergo functionalisation with various biomolecules, AuNPs are emerging as the material of choice to develop LSPR transducers [84,92,93] even though the magnitude of their relative scattering efficiency is lower than that of AgNPs [86]. Although aluminum nanoparticles display an analogous oxidation behavior to AgNPs, it is emerging as an important material for transduction in LSPR because of lucrative preparation strategies that allow spectral tunability within the ultraviolet (UV)/ visible (vis) range [59,86,94,95].…”

Section: Localised Surface Plasmon Resonance Sensors For Biomedical Dmentioning

confidence: 99%

“…Another group also reported a similar technique for the ultrasensitive detection of inorganic pyrophosphatase activity [98]. AuNR functionalisation with nucleic acids [99,100] as well as antibodies [93,101,102] has been widely reported. Kong's group developed a neoteric and cost-efficient sensor for the detection of bleomycin, a drug commonly administered in the treatment of lymphoma, ovarian as well as testicular cancer [103].…”

Section: Localised Surface Plasmon Resonance Sensors For Biomedical Dmentioning

confidence: 99%

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Recent Progress in Optical Sensors for Biomedical Diagnostics

Pirzada

Altıntaş

2020

Micromachines

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In recent years, several types of optical sensors have been probed for their aptitude in healthcare biosensing, making their applications in biomedical diagnostics a rapidly evolving subject. Optical sensors show versatility amongst different receptor types and even permit the integration of different detection mechanisms. Such conjugated sensing platforms facilitate the exploitation of their neoteric synergistic characteristics for sensor fabrication. This paper covers nearly 250 research articles since 2016 representing the emerging interest in rapid, reproducible and ultrasensitive assays in clinical analysis. Therefore, we present an elaborate review of biomedical diagnostics with the help of optical sensors working on varied principles such as surface plasmon resonance, localised surface plasmon resonance, evanescent wave fluorescence, bioluminescence and several others. These sensors are capable of investigating toxins, proteins, pathogens, disease biomarkers and whole cells in varied sensing media ranging from water to buffer to more complex environments such as serum, blood or urine. Hence, the recent trends discussed in this review hold enormous potential for the widespread use of optical sensors in early-stage disease prediction and point-of-care testing devices.

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“…Metal nanostructures can likely be used in various applications, such as in optical phenomenon enhancement devices [1][2][3], optical energy conversion devices [4,5], and sensors due to their unique optical properties. In particular, in sensor applications, they have been studied as fluorescence [6][7][8][9], Raman scattering enhancement elements [10][11][12][13], and as transducers that exhibit changes in optical properties from changes in the peripheral refractive index (dielectric constant) originating from biomolecules [14][15][16]. The optical uniqueness of metal nanostructures is derived from localized surface plasmon resonance (LSPR).…”

Section: Introductionmentioning

confidence: 99%

Modulating Optical Characteristics of Nanoimprinted Plasmonic Device by Re-Shaping Process of Polymer Mold

et al. 2021

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Metal nanostructures exhibit specific optical characteristics owing to their localized surface plasmon resonance (LSPR) and have been studied for applications in various optical devices. The LSPR property strongly depends on the size and shape of metal nanostructures; thus, plasmonic devices must be designed and fabricated according to their uses. Nanoimprint lithography (NIL) is an effective process for repeatedly fabricating metal nanostructures with controlled sizes and shapes and require optical properties. NIL is a powerful method for mass-producible, low-cost, and large-area fabrication. However, the process lacks flexibility in adjusting the size and shape according to the desirable optical characteristics because the size and shape of metal nanostructures are determined by a single corresponding mold. Here, we conducted a re-shaping process through the air-plasma etching of a polymer’s secondary mold (two-dimensional nanopillar array made of cyclo-olefin polymer (COP)) to modulate the sizes and shapes of nanopillars; then, we controlled the spectral characteristics of the imprinted plasmonic devices. The relationship between the structural change of the mold, which was based on etching time, and the optical characteristics of the corresponding plasmonic device was evaluated through experiments and simulations. According to evaluation results, the diameter of the nanopillar was controlled from 248 to 139 nm due to the etching time and formation of a pit structure. Consequently, the spectral properties changed, and responsivity to the surrounding dielectric environment was improved. Therefore, plasmonic devices based on the re-shaped COP mold exhibited a high responsivity to a refractive index of 906 nm/RIU at a wavelength of 625 nm.

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A label-free biosensor based on localized surface plasmon resonance for diagnosis of tuberculosis

Cited by 19 publications

References 20 publications

Optical Biosensors for Therapeutic Drug Monitoring

Optical Biosensors for Therapeutic Drug Monitoring

Recent Progress in Optical Sensors for Biomedical Diagnostics

Modulating Optical Characteristics of Nanoimprinted Plasmonic Device by Re-Shaping Process of Polymer Mold

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