A label-free and highly sensitive DNA biosensor based on the core-shell structured CeO2-NR@Ppy nanocomposite for Salmonella detection

Nguyệt, Nguyễn Thị Minh; Yen, Le Thi Hai; Doan, Vu Y.; Hoang, Nguyen Luong; Thu, Vu Van; Hoang, Lan; Trung, Tran; Pham, Vuong-Hung; Tam, Phuong Dinh

doi:10.1016/j.msec.2018.11.059

Cited by 41 publications

(22 citation statements)

References 31 publications

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“…This type of biosensors requires only one recognition element, which leads to simplification of the pattern of analysis, reducing both the analysis time and expenditures for reagents. The latest generation of label-free biosensors provides real-time quantification of products of biomolecular reaction, which makes it possible to perform continuous data recording, allowing kinetic monitoring of parameters of the ligand-receptor interaction recognition process [24,32,[77][78][79][80].…”

Section: Label-free Biosensorsmentioning

confidence: 99%

“…They can generate signal immediately after binding to the recognition element and do not require additional interactions with the labels that provide signal. In this context, many physicochemical types of transducers have been proposed that transform the results of bioreceptor-based binding of selected targets (for example, increase in weight, specific resistance, or surface refractive indices), which are recognized in various ways [29,71,78,89,90].…”

Section: Label-free Biosensorsmentioning

confidence: 99%

“…Among the label-free biosensors using optical signal converters, it is worth highlighting devices based on surface plasmon resonance (SPR), which can have different principles for taking the output signal and have different technical characteristics (sensitivity, size, wavelength ranges, and others). Registration of SPR is based on a system containing a source of monochromatic linearly polarized light, a glass prism, a metal film on the surface of the prism, and a photodetector [78,85] (Figure 5).…”

Section: Label-free Biosensors With Optical Convertermentioning

confidence: 99%

“…A ray of light incident on the base of a prism undergoes total internal reflection for incidence angles greater than critical and is accompanied by the appearance of a damped wave propagating from the prism into the metal layer [78,83,93]. The effect of the detection of biological molecules in optical biosensors based on SPR consists in a change (increase) in the intensity of the reflected beam during the course of the reaction.…”

Section: Label-free Biosensors With Optical Convertermentioning

confidence: 99%

“…In recent years, the main direction of research in the field of biodetection based on SPR has been the search for new methods to increase their sensitivity (for example, using Au-Ag electrode coatings, creation a periodic metal-dielectric structure on the surface of a metal film, or using long-range plasmons) [38,56,72,78,85]. A ray of light incident on the base of a prism undergoes total internal reflection for incidence angles greater than critical and is accompanied by the appearance of a damped wave propagating from the prism into the metal layer [78,83,93]. The effect of the detection of biological molecules in optical biosensors based on SPR consists in a change (increase) in the intensity of the reflected beam during the course of the reaction.…”

Section: Label-free Biosensors With Optical Convertermentioning

confidence: 99%

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Label-Free Biosensors for Laboratory-Based Diagnostics of Infections: Current Achievements and New Trends

et al. 2020

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Infections pose a serious global public health problem and are a major cause of premature mortality worldwide. One of the most challenging objectives faced by modern medicine is timely and accurate laboratory-based diagnostics of infectious diseases. Being a key factor of timely initiation and success of treatment, it may potentially provide reduction in incidence of a disease, as well as prevent outbreak and spread of dangerous epidemics. The traditional methods of laboratory-based diagnostics of infectious diseases are quite time- and labor-consuming, require expensive equipment and qualified personnel, which restricts their use in case of limited resources. Over the past six decades, diagnostic technologies based on lateral flow immunoassay (LFIA) have been and remain true alternatives to modern laboratory analyzers and have been successfully used to quickly detect molecular ligands in biosubstrates to diagnose many infectious diseases and septic conditions. These devices are considered as simplified formats of modern biosensors. Recent advances in the development of label-free biosensor technologies have made them promising diagnostic tools that combine rapid pathogen indication, simplicity, user-friendliness, operational efficiency, accuracy, and cost effectiveness, with a trend towards creation of portable platforms. These qualities exceed the generally accepted standards of microbiological and immunological diagnostics and open up a broad range of applications of these analytical systems in clinical practice immediately at the site of medical care (point-of-care concept, POC). A great variety of modern nanoarchitectonics of biosensors are based on the use of a broad range of analytical and constructive strategies and identification of various regulatory and functional molecular markers associated with infectious bacterial pathogens. Resolution of the existing biosensing issues will provide rapid development of diagnostic biotechnologies.

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Section: Label-free Biosensorsmentioning

confidence: 99%

Section: Label-free Biosensorsmentioning

confidence: 99%

Section: Label-free Biosensors With Optical Convertermentioning

confidence: 99%

Section: Label-free Biosensors With Optical Convertermentioning

confidence: 99%

Section: Label-free Biosensors With Optical Convertermentioning

confidence: 99%

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Label-Free Biosensors for Laboratory-Based Diagnostics of Infections: Current Achievements and New Trends

et al. 2020

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Dual‐mode biosensing platform for ultrasensitive Salmonella detection based on cascaded signal amplification coupled with DNA‐functionalized Ag₂S NPs@PB

Jiao

Kang

et al. 2023

Food Frontiers

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Salmonella is one of the most common zoonotic foodborne pathogens and can cause serious threats to public health and global economy. A dual‐mode biosensing platform was demonstrated based on cascaded signal amplification coupled with DNA‐functionalized Ag2S NPs@PB (Ag2S NPs@PB‐DNA) for ultrasensitive and selective Salmonella detection. Specifically, once Salmonella was recognized and captured by the control probe, the primer was released to trigger rolling circle amplification and generate a multimeric single‐stranded DNA (ssDNA) with repetitive sequences. The ssDNA could form multicomponent nucleic acid enzyme with cleavage activity to destroy multiple pieces of L‐DNA, achieving cascaded signal amplification and cleaving L‐DNA as a linker between DNA‐functionalized magnetite microspheres (MMs@DNA) and Ag2S NPs@PB‐DNA, leading to reduction in the capture of Ag2S NPs@PB by MMs@DNA. Due to the excellent photothermal properties of Ag2S NPs@PB under near‐infrared irradiation, the changes of temperature and pressure could be simultaneously monitored in the detection system, and the dual‐mode biosensing platform showed outstanding sensitivity, with a limit of the detection value of 100 CFU mL−1 in temperature and 101 CFU mL−1 in pressure. Moreover, the developed biosensing platform could successfully detect 5.7 CFU of Salmonella in spiked chicken breast after 4 h of enrichment. All the results show this study provides a new avenue for specific, sensitive, and convenient bacterial detection in food analysis and environment safety.

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Introduction to Biosensing

Ahmad

Guleria

Kumar

2023

Handbook of II-VI Semiconductor-Based Sensors and Radiation Detectors

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A label-free and highly sensitive DNA biosensor based on the core-shell structured CeO2-NR@Ppy nanocomposite for Salmonella detection

Cited by 41 publications

References 31 publications

Label-Free Biosensors for Laboratory-Based Diagnostics of Infections: Current Achievements and New Trends

Label-Free Biosensors for Laboratory-Based Diagnostics of Infections: Current Achievements and New Trends

Dual‐mode biosensing platform for ultrasensitive Salmonella detection based on cascaded signal amplification coupled with DNA‐functionalized Ag₂S NPs@PB

Introduction to Biosensing

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A label-free and highly sensitive DNA biosensor based on the core-shell structured CeO2-NR@Ppy nanocomposite for Salmonella detection

Cited by 41 publications

References 31 publications

Label-Free Biosensors for Laboratory-Based Diagnostics of Infections: Current Achievements and New Trends

Label-Free Biosensors for Laboratory-Based Diagnostics of Infections: Current Achievements and New Trends

Dual‐mode biosensing platform for ultrasensitive Salmonella detection based on cascaded signal amplification coupled with DNA‐functionalized Ag2S NPs@PB

Introduction to Biosensing

Contact Info

Product

Resources

About

Dual‐mode biosensing platform for ultrasensitive Salmonella detection based on cascaded signal amplification coupled with DNA‐functionalized Ag₂S NPs@PB