A key review on oxadiazole analogs as potential methicillin-resistant Staphylococcus aureus (MRSA) activity: Structure-activity relationship studies

Verma, Santosh Kumar; Verma, Rameshwari; Kumar, Kothanahally S. Sharath; Banjare, Laxmi; Shaik, Afzal B.; Bhandare, Richie R.; Rakesh, K.P.; Rangappa, Kanchugarakoppal S.

doi:10.1016/j.ejmech.2021.113442

Cited by 66 publications

(20 citation statements)

References 100 publications

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“…Oxadiazoles as very common structural units can frequently be found in natural and pharmaceutical products . The incorporation of the -CF 3 group into oxadiazole scaffolds could dramatically improve their lipophilicity and metabolic stability .…”

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confidence: 99%

2,2,2-Trifluoroacetaldehyde O-(Aryl)oxime: A Precursor of Trifluoroacetonitrile

et al. 2022

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The preparation of 2,2,2-trifluoroacetaldehyde O-(aryl)oxime, a previously inaccessible precursor of trifluoroacetonitrile, via reaction of hydroxylamine and trifluoroacetaldehyde hydrate is reported. This precursor released CF 3 CN in quantitative yield under mildly basic conditions. The precursor was successfully used in the synthesis of trifluoromethylated oxadiazoles. The facile, cost-effective, scalable, and recyclable procedure makes these trifluoroacetonitrile precursors generally applicable.

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confidence: 99%

2,2,2-Trifluoroacetaldehyde O-(Aryl)oxime: A Precursor of Trifluoroacetonitrile

et al. 2022

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“…2019; Verma et al . 2021). Given that 1,3,4‐oxadiazoles are promising agents for controlling food pathogens, this study investigated the antibacterial and antibiofilm activities of the oxadiazole compound LMM6 in S. aureus .…”

Section: Resultsmentioning

confidence: 99%

“…1,3,4-Oxadiazole, a pivotal five-membered nitrogencontaining heterocycle, is an interesting pharmacophore in medicinal chemistry (Li et al 2018). The derivatives of 1,3,4-oxadiazole compounds, which comprise a class of heterocyclic compounds with potent antibacterial activity, have been widely studied (Othman et al 2019;Verma et al 2019;Verma et al 2021). Given that 1,3,4oxadiazoles are promising agents for controlling food pathogens, this study investigated the antibacterial and antibiofilm activities of the oxadiazole compound LMM6 in S. aureus.…”

Section: Resultsmentioning

confidence: 99%

New 1,3,4-oxadiazole compound with effective antibacterial and antibiofilm activity against Staphylococcus aureus

Formagio

Silva

Prohmann

et al. 2022

Letters in Applied Microbiology

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Staphylococcus aureus is one of the main aetiological agents causing food‐borne diseases. Some strains produce enterotoxins responsible for food poisoning. In addition, they can form biofilms on several surfaces such as plastics, glass and stainless steel making it difficult to eliminate them. The present study evaluated, for the first time, the antibacterial and antibiofilm activities of the synthetic compound LMM6 against S. aureus. The minimum inhibitory concentration was 0·97, 1·95 and 1·95 μg ml−1 against S. aureus ATCC 25923, S. aureus 629/94 and S. aureus FRI S‐6, respectively. The time‐kill curves showed that 96 h treatment with LMM6 reduced approximately 4 log CFU per ml at all tested concentrations. Furthermore, LMM6 reduced S. aureus preformed biofilm by approximately 1 log CFU per cm2. During biofilm formation, a reduction of approximately 4 log CFU per cm2 was observed. LMM6 also reduced biofilm biomass during (~60%) and after biofilm formation (~25 to 45%), as shown by the crystal violet assay. Based on these results, we conclude that LMM6 exhibits antibacterial and antibiofilm activity and may be an innovative synthetic molecule for controlling S. aureus.

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“…This technology was therefore, utilized for the sequence determination of MRSA isolate RWP1. MRSA is easily transmissible and becoming a public health threat due to emergence of antibiotic resistance (Verma et al, 2021). It is also difficult to resolve as it may persist due to biofilm formation (Carrera-Salinas et al, 2022).…”

Section: Figmentioning

confidence: 99%

Nanopore sequencing of human associated methicillin-resistant Staphylococcus aureus RWP1 genome for inferring antibiotic resistant gene, plasmid and prophage information

Basharat

2022

Preprint

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Methicillin-resistant Staphylococcus aureus (MRSA) is a gram-positive bacterium and responsible for several infections in the human. Here, Oxford nanopore mediated whole genome sequencing is reported for human host associated strain. The genome size obtained was of ~3 MB, while GC content was 32.9%. Approximately 3600 CDSs, 62 tRNAs and 16 rRNAs were identified. Phage segments were present, with two complete intact phages. Type I and type IV restriction elements were also detected, along with five plasmids. Several antibiotic resistance genes were also mined, with a key mutation in the fluoroquinolone resistant gyrA, phosphonic acid resistant murA transferase and fusidic acid resistant fusA genes. Sequence type was determined as 4803. Comparative analysis with MRSA isolates from Pakistan (n=20) revealed an open pan-genome, with 1,934 CDSs forming core genome.

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A key review on oxadiazole analogs as potential methicillin-resistant Staphylococcus aureus (MRSA) activity: Structure-activity relationship studies

Cited by 66 publications

References 100 publications

2,2,2-Trifluoroacetaldehyde O-(Aryl)oxime: A Precursor of Trifluoroacetonitrile

2,2,2-Trifluoroacetaldehyde O-(Aryl)oxime: A Precursor of Trifluoroacetonitrile

New 1,3,4-oxadiazole compound with effective antibacterial and antibiofilm activity against Staphylococcus aureus

Nanopore sequencing of human associated methicillin-resistant Staphylococcus aureus RWP1 genome for inferring antibiotic resistant gene, plasmid and prophage information

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