“…When the high outer reduction factor (R) is applied for GRAPPA, the reconstruction noises will increase distinctly. Therefore, an amount of reconstruction methods have been proposed to reduce aliasing artifacts and noised for improving image quality, such as, regularization [5], reweighted least squares [6], high-pass filtering [7], cross-validation [8], iterative optimization [9], virtual coil using conjugate symmetric signals [10], multi-slice weighting [11], an infinite impulse response model [12], nonlinear model [13], etc. Only a few methods modify the data acquisition procedure to improve GRAPPA, such as, variable density sampling [14], cross sampling [15], etc.…”