A joint experimental and theoretical structural study of novel substituted 2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinolines

A green and efficient method for the synthesis of homodimeric (β-dicarbonyl) arylmethanes and dihydropyridine from dimedone in water

“…The molecule dimedone 1, known for a long time, has been scarcely used in the synthesis of heterocyclic structures [7][8][9][10][11][12][13]. According to the literature, the homodimer 3 of dimedone has been obtained in various organic solvents like acetic acid and in the presence of toxic and not toxic catalysts such as cyanuric chloride and triethylamine.…”

Synthesis, characterization and biological activity of some new carbostyril bearing 1H-pyrazole moiety

“…Literature survey Tu et al, 2001Tu et al, , 2006Suarez et al, 1999) reveals few studies concerning N-substituted quinolin-2-one derivatives of aromatic aldehyde, but not a single reference where 1H-1,3-diaryl pyrazole-4-carbaldehydes are used and evaluated for their antimicrobial potency.…”

Activated Anilide in Heterocyclic Synthesis: Synthesis of New Dihydropyridines, Dihydropyridazines and Thiourea Derivatives

“…19 However, the yields of 1,4-dihydropyridines obtained by this method are generally low and several methods have been described for the synthesis of 1,4-dihydropyridine. [20][21][22][23][24] Also heterocyclic thiourea derivatives are known to exhibit diverse bioactivities such as antiviral, 25 antitubercular, 26 fungicidal, 27 and herbicidal 28 activities. In conjunction with our interest in the synthesis of azines and condensed azines, 29,30 we study here the readily obtainable butanamide and pyridine derivatives as starting materials for the synthesis of a new series of polyfunctionally substituted 1,4-dihydropyridines, 2,5-dihydropyridazines and thiourea derivatives in a good yields.…”