A Japanese Survey of Perioperative Antibiotic Prophylaxis in Cataract Surgery

Matsuura, Kazuki; Suto, Chikako; Inoue, Yoshitsugu; Saeki, Yusuke; Miyamoto, Takeshi; Mori, Taisuke; Ohkubo, Shinji; Tanito, Masaki

doi:10.1097/apo.0b013e31826cd8f2

Cited by 4 publications

(1 citation statement)

References 20 publications

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“…We selected the following eight regions to avoid an uneven sampling distribution: Fukushima, Ishikawa, Saitama, Wakayama, San’in, Fukuoka, Shiga, and Kagawa ( Figure 1 ). In 2012, we conducted a similar survey 16 in six of the eight regions, not including Shiga and Kagawa. For comparison, the participants in Shiga and Kagawa were requested to fulfill the surveys from both 2012 and 2014.…”

Section: Methodsmentioning

confidence: 99%

Survey of Japanese ophthalmic surgeons regarding perioperative disinfection and antibiotic prophylaxis in cataract surgery

Matsuura

Mori

Miyamoto

et al. 2014

OPTH

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PurposeTo elucidate Japanese trends for perioperative disinfection and antibiotic selection during cataract surgeries.MethodsPerioperative iodine use and antibiotic prophylaxis for cataract surgery were surveyed in eight regions in Japan by mail or through interviews from February 1 to March 1, 2014.ResultsWe surveyed 572 surgeons, of whom 386 (67%) responded. Most of the surgeons (94%) used iodine compounds before surgery for periocular skin disinfection (povidone–iodine [PI]: 79%; polyvinyl alcohol-iodine [PAI]: 15%) or conjunctival disinfection (85%; PI: 36%; PAI: 49%). Preoperative conjunctival iodine was primarily used as an eye wash (irrigation: 95%) and less often as an eye drop (5%). It was determined that 31% of surgeons waited 30 seconds or more between periocular disinfection and conjunctival disinfection. During surgery, 14% of surgeons used iodine several times, including immediately before intraocular lens insertion, and 7% used the Shimada technique (repeated iodine irrigation). Preoperative antibiotic eye drops were used by 99% of surgeons, and antibiotics were added to the irrigation bottle by 22%. The surgeons reported use of subconjunctival antibiotic injections (23%), antibiotic ointments (79%), and intracameral antibiotics (7%: 22 moxifloxacin; 6 levofloxacin). All surgeons prescribed postoperative eye drops, with 10% initiating the drops on the day of surgery.ConclusionIodine compounds are commonly used preoperatively, but few institutions use iodine compounds intraoperatively, particularly with repeated application. The selection of antibiotic administration and disinfection technique has to be at the surgeon’s discretion. However, intracameral antibiotic and intraoperative iodine compound use are techniques that should be widely recognized.

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Section: Methodsmentioning

confidence: 99%

Survey of Japanese ophthalmic surgeons regarding perioperative disinfection and antibiotic prophylaxis in cataract surgery

Matsuura

Mori

Miyamoto

et al. 2014

OPTH

Self Cite

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Comparison between intracameral moxifloxacin administration methods by assessing intraocular concentrations and drug kinetics

Matsuura¹,

Suto

Akura

et al. 2013

Graefes Arch Clin Exp Ophthalmol

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Considering that the half-life of MFLX was >1 h, a final concentration of 150 μg/ml results in a 2 h concentration of 38 μg/ml, which was beyond the minimum inhibitory concentration required to inhibit the growth of 90% of bacteria (MIC90) for most resistant pathogens. We postulate that a final concentration of 150 μg/ml is considerably effective and safe. However, more resistant bacteria will evolve in the future, and the standard MIC90 may change accordingly. Therefore, even if a suitable concentration is determined, it may not necessarily remain constant. This effective concentration should be continually revised on the basis of safety and effectiveness assessments.

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Efficacy and safety of prophylactic intracameral moxifloxacin injection in Japan

Matsuura¹,

Miyoshi²,

Suto³

et al. 2013

Journal of Cataract and Refractive Surgery

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A Japanese Survey of Perioperative Antibiotic Prophylaxis in Cataract Surgery

Cited by 4 publications

References 20 publications

Survey of Japanese ophthalmic surgeons regarding perioperative disinfection and antibiotic prophylaxis in cataract surgery

Survey of Japanese ophthalmic surgeons regarding perioperative disinfection and antibiotic prophylaxis in cataract surgery

Comparison between intracameral moxifloxacin administration methods by assessing intraocular concentrations and drug kinetics

Efficacy and safety of prophylactic intracameral moxifloxacin injection in Japan

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