Abstract:word count: 192 21 Text word count: 9082 22 Abstract 23 F. tularensis is a Gram-negative, intracellular bacterium that causes the zoonotic disease 24 tularemia. Intracellular pathogens, including F. tularensis, have evolved mechanisms to allow 25survival in the harsh environment of macrophages and neutrophils, where they are exposed to 26 cell membrane-damaging molecules. One mechanism that protects intracellular Gram-negative 27 bacteria from macrophage or neutrophil killing is the ability to recycle and repa… Show more
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