2000
DOI: 10.1126/science.287.5461.2229
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A Drosophila Mechanosensory Transduction Channel

Abstract: Mechanosensory transduction underlies a wide range of senses, including proprioception, touch, balance, and hearing. The pivotal element of these senses is a mechanically gated ion channel that transduces sound, pressure, or movement into changes in excitability of specialized sensory cells. Despite the prevalence of mechanosensory systems, little is known about the molecular nature of the transduction channels. To identify such a channel, we analyzed Drosophila melanogaster mechanoreceptive mutants for defect… Show more

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Cited by 639 publications
(569 citation statements)
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“…Moreover, hydrogen bonding between the hydroxyl group of Thr and the imidazole ring of His contributes to the stability of AR motif and global AR proteins (16) (Figure 1c). The Val/IleVal-Xxx (hydrophilic)-Leu/Val-Leu-Leu motif (positions [17][18][19][20][21][22] is the central piece of the second R-helix of an AR motif, and it functions to form intra-and inter-AR hydrophobic networks to stabilize the global sketch of an AR protein (5,8). In addition, glycine residues are conserved at positions 13 and 25, which terminate the helices and provide the freedom for a loop to link both helices (5).…”
Section: Structurementioning
confidence: 99%
“…Moreover, hydrogen bonding between the hydroxyl group of Thr and the imidazole ring of His contributes to the stability of AR motif and global AR proteins (16) (Figure 1c). The Val/IleVal-Xxx (hydrophilic)-Leu/Val-Leu-Leu motif (positions [17][18][19][20][21][22] is the central piece of the second R-helix of an AR motif, and it functions to form intra-and inter-AR hydrophobic networks to stabilize the global sketch of an AR protein (5,8). In addition, glycine residues are conserved at positions 13 and 25, which terminate the helices and provide the freedom for a loop to link both helices (5).…”
Section: Structurementioning
confidence: 99%
“…These neurons express the TRPN channel TRP-4 [48]. The trp-4 gene is an ortholog of the fruitfly and zebrafish nompC genes [74,88]. Because trp-4 mutants do not slow on entering a bacterial lawn [48], TRP-4 may have a role in transducing textural stimuli.…”
Section: Other Mechanosensory Behaviorsmentioning
confidence: 99%
“…One such gene is trp-4 [48]. As previously mentioned, TRP-4 is expressed in the dopaminergic neurons required for food-mediated slowing, but it is also expressed in the DVA interneuron [88]. The DVA cell body is located in the head, but it sends a process that extends for the entire length of the ventral cord [91].…”
Section: Other Mechanosensory Behaviorsmentioning
confidence: 99%
“…Trp is now a large family that encompasses channels of diverse functions from the receptors of heat, vanilloid, and menthol to possibly the store-operated channels (4). Among Trp-family channels, Osm9 (5), no mechanoreceptor potential C (nompC) (6), stretch inhibitable channel (SIC) (7), polycystin-2 (PC2) (8), and vanilloid receptor-related osmotically activated channel (VR-OAC) (9) are associated with mechanosensitivity in different animals. In prokaryotes, the MS channels MscL and MscS have been cloned, expressed, and crystallized (10)(11)(12)(13).…”
mentioning
confidence: 99%