A de novo strategy for the development of a Zn^II–organic framework based luminescent “switch-on” assay for size-exclusive sensitization of the oxidised form of glutathione (GSSG) over the reduced form (GSH): insights into the sensing mechanism through DFT

Abstract

The ratio of oxidized L-glutathione (GSSG) to reduced L-glutathione (GSH) plays a key role as biomarker for monitoring cellular health thus fueling extensive ground-breaking research towards development of sensory receptor...

Fluorescent MOF and Its Gel Composite for the Fluorescence Recovery “Turn-On” Detection of Al3+ Ions and “Turn-Off” Detection of Oxo-Anions

“…Quite well-known, the framework fabricated from the d 10 metal node/clustered with pi conjugated organic linker is expected to be fluorescent and these materials would be applied for potential sensing applications. , Here, the framework is developed from the Cd­(II) metal ion, which is a d 10 electron system, i.e., a closed shell electronic configuration and the linker H 2 L contains an anthracene moiety. Therefore, it is anticipated that their combination would result in a luminescent network.…”

Simple and Cost-Effective Quantum Dot Chemodosimeter for Visual Detection of Biothiols in Human Blood Serum

“…Various approaches for qualitative as well as quantitative analysis of these bioanalytes have been developed, mainly based on electroanalytical techniques, , high-performance liquid chromatography (HPLC), , capillary electrophoresis separation, immunoassays based on derivatization with fluorescent/phosphorescent reagents, spectrophotometric methods, etc. , Unfortunately, all of these methods require either expensive reagents or equipment or skilled manpower to ensure reproducibility. In this context, much attention is being paid to the development of simple and cheap fluorescent probes, without compromising selectivity and sensitivity. − Nanoparticles have been proven to be an efficient substitute for organic fluorophores, particularly for developing emission “turn on/off” sensors. − Among various nanoparticles, quantum dots (QDs) are of particular interest in developing novel biosensors owing to their unique properties such as broad absorption band, emission in the visible region, photostability, etc. − Moreover, the potential of QDs to transfer electrons or holes to biologically important molecules, interacting covalently or noncovalently with their surface, can be used to tune the QD emission intensity and thus generate charge transfer-based emission “on/off” signaling. − …”

Engineering of metal–organic frameworks (MOFs) for thermometry

“…Interestingly, lanthanide-based MOFs behave as multi-emissive and self-referencing sensors, where the ratiometric sensing property of the MOF would reveal the luminescence thermometry, allowing the construction of a temperature-sensing probe. [42][43][44][45][46] Interestingly, the amalgamation of a fluorophore in the MOF network leads to the generations of thermometric probes. 47,48 The diverse ligands that are employed for the construction of ratiometric MOF thermometers are listed in Scheme 1.…”