“…14 Another interesting application of triazole was to employ it as a cis-amide bond surrogate. 15 Replacement of the Ala-NMe-Tyr(OMe) amide bond in RA-VII, a plant-origin anti-tumor bicyclic hexapeptide, with [1,2,4]triazole yielded michael_chorev@hms.harvard.edu. SUPPORTING INFORMATION: General procedures for synthesis, 1 HNMR of 3a, 3c, 4a, 4b, 4c, 4k, 6c, 6d, 7d and 6f; 13 CNMR of 3a, 4a, 4b, 4k, 6c, 7d and 6f; LCMS of 3c, 4c, 6d-7d regioisomeric mixture and 6e-7e regioisomeric mixture and NOESY and TOCSY of 6c, 6f and 6g.…”