A Hypomagnetic Field Aggravates Bone Loss Induced by Hindlimb Unloading in Rat Femurs

Jia, Bin; Xie, Li; Zheng, Qi; Yang, Pengfei; Zhang, Wei-ju; Ding, Chong; Qian, Airong; Shang, Peng

doi:10.1371/journal.pone.0105604

Cited by 34 publications

(31 citation statements)

References 69 publications

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“…By zero, we imply low in relationship to the geomagnetic field H geo of about 40000 nT. Many publications confirm the biological efficacy of such weak MFs [e.g., Choleris et al, ; Sarimov et al, ; Burger et al, ; Jia et al, ].…”

Section: Nonuniform Precession and Magnetoreceptionmentioning

confidence: 86%

“…By zero, we imply low in relationship to the geomagnetic field H geo of about 40000 nT. Many publications confirm the biological efficacy of such weak MFs [e.g., Choleris et al, 2002;Sarimov et al, 2008;Burger et al, 2010;Jia et al, 2014]. Interestingly, h ¼ H ¼ 0 is not the only magnetic mode for significant changes in the natural precession.…”

Section: Stopping the Magnetic Moment Precessionmentioning

confidence: 87%

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A physical mechanism of magnetoreception: Extension and analysis

Binhi

Prato

2016

Bioelectromagnetics

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Proposed is a general physical mechanism of magnetoreception of weak magnetic fields (MFs). The mechanism is based on classical precessional dynamics of a magnetic moment in a thermally disturbed environment and includes a minimum of necessary parameters-the gyromagnetic ratio, thermal relaxation time, and rate of downstream events generated by changes in the state of the magnetic moment. The mechanism imposes general restrictions on the probability of initial biophysical magnetic transduction event before the involvement of specific biophysical and biochemical mechanisms-i.e., regardless of the nature of an MF target and the subsequent cascade of events. It is shown that biological effects of weak MFs have, in certain cases, nonlinear and frequency selective properties. The observation of these characteristics provides information not only on the target's gyromagnetic ratio, but also on the parameters of its interaction with the immediate environment. This enables one to develop experimental strategies for identifying the biophysical mechanisms of magnetoreception including the specific case of effects of a near-zero MF exposure. The mechanism is universally applicable to magnetic moments of different nature, in particular, of electron and proton orbital motion and of spins. Experimental exposure conditions are derived which would lead to validation of the proposed mechanism. Bioelectromagnetics. 38:41-52, 2017. © 2016 Wiley Periodicals, Inc.

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Section: Nonuniform Precession and Magnetoreceptionmentioning

confidence: 86%

Section: Stopping the Magnetic Moment Precessionmentioning

confidence: 87%

A physical mechanism of magnetoreception: Extension and analysis

Binhi

Prato

2016

Bioelectromagnetics

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“…We raise a hypothesis that 16 T SMF had inhibited effects on osteoclast activity, while its formation and differentiation could be enhanced by intensities of 500 nT and 0.2 T. In order to test our hypothesis, we investigated the regulatory role of SMFs on osteoclastogenesis and the ability of the bone resorption of osteoclast precursor RAW264.7 cells under such SMFs as HyMF, GMF, MMF to HiMF. The present study utilized HyMF of about 500 nT (created by a magnetic shielding room), MMF of 0.2-0.4 T (surrounding a superconducting magnet) and HiMF of 16 T (generated by a superconducting magnet) based on our previous studies (Jia et al, 2014;Wang et al, 2009;Qian et al, 2009Qian et al, , 2013.…”

Section: Introductionmentioning

confidence: 99%

Regulation of osteoclast differentiation by static magnetic fields

Zhang

Meng

Ding

et al. 2016

Electromagnetic Biology and Medicine

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Static magnetic field (SMF) modulates bone metabolism, but little research is concerned with the effects of SMF on osteoclast. Our previous studies show that osteogenic differentiation is strongly correlated with magnetic strength from hypo (500 nT), weak (geomagnetic field, GMF), moderate (0.2 T) to high (16 T) SMFs. We speculated that the intensity that had positive (16 T) or negative (500 nT and 0.2 T) effects on osteoblast differentiation would inversely influence osteoclast differentiation. To answer this question, we examined the profound effects of SMFs on osteoclast differentiation from pre-osteoclast Raw264.7 cells. Here, we demonstrated that 500 nT and 0.2 T SMFs promoted osteoclast differentiation, formation and resorption, while 16 T had an inhibitory effect. Almost all the osteoclastogenic genes were highly expressed under 500 nT and 0.2 T, including RANK, matrix metalloproteinase 9 (MMP9), V-ATPase, carbonic anhydrase II (Car2) and cathepsin K (CTSK), whereas they were decreased under 16 T. In addition, 16 T disrupted actin formation with remarkably decreased integrin β3 expression. Collectively, these results indicate that osteoclast differentiation could be regulated by altering the intensity of SMF, which is just contrary to that on osteoblast differentiation. Therefore, studies of SMF effects could reveal some parameters that could be used as a physical therapy for various bone disorders.

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“…Numerous studies have shown that HyMF has a negative impact on many aspects of life activities, including the structure and function of the central nervous system, circadian rhythm, and bone in the body . We have shown that HyMF can accelerate HLU‐induced bone loss in rats and mice . In this study, we explored the effects of HyMF on bone of HLU mice in reloading.…”

Section: Discussionmentioning

confidence: 99%

“…In vitro, we found that HyMF can inhibit osteoblast differentiation and mineralization, and promote osteoclast formation and bone resorption . In vivo, HyMF aggravated bone loss induced by hindlimb unloading (HLU) in rats and mice . Therefore, as an non‐negligible risk factor in space, HyMF participates in spatial bone loss.…”

Section: Introductionmentioning

confidence: 92%

Disorder of Iron Metabolism Inhibits the Recovery of Unloading-Induced Bone Loss in Hypomagnetic Field

Xue

Yang

Luo

et al. 2019

Journal of Bone and Mineral Research

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Exposure of humans and animals to microgravity in spaceflight results in various deleterious effects on bone health. In addition to microgravity, the hypomagnetic field (HyMF) is also an extreme environment in space, such as on the Moon and Mars; magnetic intensity is far weaker than the geomagnetic field (GMF) on Earth. Recently, we showed that HyMF promoted additional bone loss in hindlimb unloading–induced bone loss, and the underlying mechanism probably involved an increase of body iron storage. Numerous studies have indicated that bone loss induced by mechanical unloading can be largely restored after skeletal reloading in GMF conditions. However, it is unknown whether this bone deficit can return to a healthy state under HyMF condition. Therefore, the purpose of this study is to examine the effects of HyMF on the recovery of microgravity‐induced bone loss, and illustrates the changes of body iron storage in this process. Our results showed that there was lower bone mineral content (BMC) in the HyMF reloading group compared to the GMF reloading group. Reloaded mice in the HyMF condition had a worse microstructure of femur than in the GMF condition. Femoral mechanical properties, including elastic modulus, stiffness, and ultimate stress, were poorer and toughness was higher in the HyMF group compared with the GMF group. Simultaneously, more iron content in serum, the tibia, liver, and spleen was found under HyMF reloading than GMF reloading. The iron chelator deferoxamine mesylate (DFO) decreased the iron content in the bone, liver, and spleen, and significantly relieved unloading‐induced bone loss under HyMF reloading. These results showed that HyMF inhibits the recovery of microgravity‐induced bone loss, probably by suppressing the elevated iron levels’ return to physiological level. © 2019 American Society for Bone and Mineral Research.

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A Hypomagnetic Field Aggravates Bone Loss Induced by Hindlimb Unloading in Rat Femurs

Cited by 34 publications

References 69 publications

A physical mechanism of magnetoreception: Extension and analysis

A physical mechanism of magnetoreception: Extension and analysis

Regulation of osteoclast differentiation by static magnetic fields

Disorder of Iron Metabolism Inhibits the Recovery of Unloading-Induced Bone Loss in Hypomagnetic Field

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