A Hypercoagulable Hematological Metastasis Breast Cancer Model

Yang, Wenjing; Zhang, Gan-Lin; Cao, Kexin; Yang, Guoren

doi:10.1155/2021/5473959

Cited by 2 publications

(2 citation statements)

References 37 publications

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“…Tumor cells can promote the body to secrete more tissue factor (TF) which is the primary initiator of the coagulation cascade, and procoagulant substances, and interact with vascular endothelial cells, platelets, and monocytes, resulting in a hypercoagulable state [25]. And hypercoagulable state in the blood is related to the development and metastasis of cancer [26,27]. The growth and dissemination of tumor requires rapid angiogenesis, while the coagulation cascade can be activated [28].…”

Section: Discussionmentioning

confidence: 99%

Increased D-dimer level was a poor predictor of neuroblastoma, especially in the high-risk group

Li²,

Zhao³

et al. 2023

World J Surg Onc

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Purpose D-dimer levels are associated with tumor progression and prognosis in various cancers. However, there are few research about the relationship between D-dimer and neuroblastoma (NB). This study assessed the relationships of D-dimer levels with clinical features and overall survival (OS) in patients with NB. Methods Information about the clinical features of 365 patients and the prognosis of 301 patients was collected. The relationship between D-dimer levels and clinical features or OS was analyzed. We constructed the risk score based on Cox regression analysis and verified the predictive efficacy of the model through ROC curve and calibration curve. Results The results showed that D-dimer levels were significantly increased in patients with nonmediastinal tumor, tumor larger than 10 cm, stage 3–4 disease, bone marrow metastasis, unfavorable histology, bone metastasis, NMYC amplification, and the high-risk group (all P < 0.05). The Kaplan–Meier survival analysis showed that there were significant differences in 3- and 5-year OS (87.4% vs. 32.3%, 79.3% vs. 32.3%, P < 0.0001) between the low D-dimer and high D-dimer groups. In the high-risk group, the OS of high D-dimer was significantly lower than that of low D-dimer (P < 0.0001). All cases were divided into the training cohort (N = 211) and the validation cohort (N = 90). Multivariate analysis further suggested that D-dimer level, bone metastasis, and NMYC status were independent prognostic factors for OS (all P < 0.05). Based on the above three factors, we constructed the risk score in the training cohort. Survival analysis showed that compared with the other groups, the group with 11 scores had the worst prognosis (3-year OS 0%, P < 0.0001). The time-dependent ROC analysis and calibration curve indicated that the risk score had good accuracy. Conclusions Patients with high D-dimer levels tended to have unfavorable clinical characteristics and poor prognosis.

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Section: Discussionmentioning

confidence: 99%

Increased D-dimer level was a poor predictor of neuroblastoma, especially in the high-risk group

Li²,

Zhao³

et al. 2023

World J Surg Onc

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“…Being the most prevalent cancer with a high incidence rate worldwide, BC poses a severe threat to women’s health [ 86 , 87 ]. Like other cancer types described above, TM4SF1 was also overexpressed in BC [ 88 ].…”

Section: The Regulatory Roles Of Tm4sf1 In Different Cancer Typesmentioning

confidence: 99%

Three Members of Transmembrane-4-Superfamily, TM4SF1, TM4SF4, and TM4SF5, as Emerging Anticancer Molecular Targets against Cancer Phenotypes and Chemoresistance

Rahim

Sim

et al. 2023

Pharmaceuticals

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There are six members of the transmembrane 4 superfamily (TM4SF) that have similar topology and sequence homology. Physiologically, they regulate tissue differentiation, signal transduction pathways, cellular activation, proliferation, motility, adhesion, and angiogenesis. Accumulating evidence has demonstrated, among six TM4SF members, the regulatory roles of transmembrane 4 L6 domain family members, particularly TM4SF1, TM4SF4, and TM4SF5, in cancer angiogenesis, progression, and chemoresistance. Hence, targeting derailed TM4SF for cancer therapy has become an emerging research area. As compared to others, this review aimed to present a focused insight and update on the biological roles of TM4SF1, TM4SF4, and TM4SF5 in the progression, metastasis, and chemoresistance of various cancers. Additionally, the mechanistic pathways, diagnostic and prognostic values, and the potential and efficacy of current anti-TM4SF antibody treatment were also deciphered. It also recommended the exploration of other interactive molecules to be implicated in cancer progression and chemoresistance, as well as potential therapeutic agents targeting TM4SF as future perspectives. Generally, these three TM4SF members interact with different integrins and receptors to significantly induce intracellular signaling and regulate the proliferation, migration, and invasion of cancer cells. Intriguingly, gene silencing or anti-TM4SF antibody could reverse their regulatory roles deciphered in different preclinical models. They also have prognostic and diagnostic value as their high expression was detected in clinical tissues and cells of various cancers. Hence, TM4SF1, TM4SF4, and TM4SF5 are promising therapeutic targets for different cancer types preclinically and deserve further investigation.

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A Hypercoagulable Hematological Metastasis Breast Cancer Model

Cited by 2 publications

References 37 publications

Increased D-dimer level was a poor predictor of neuroblastoma, especially in the high-risk group

Increased D-dimer level was a poor predictor of neuroblastoma, especially in the high-risk group

Three Members of Transmembrane-4-Superfamily, TM4SF1, TM4SF4, and TM4SF5, as Emerging Anticancer Molecular Targets against Cancer Phenotypes and Chemoresistance

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