A hydrogel system based on a lactose-modified chitosan for viscosupplementation in osteoarthritis

Scognamiglio, Francesca; Travan, Andrea; Donati, Ivan; Borgogna, Massimiliano; Marsich, Eleonora

doi:10.1016/j.carbpol.2020.116787

Cited by 24 publications

(20 citation statements)

References 63 publications

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“…In addition, the beneficial effect of the CTL-boric acid hydrogel was related also to its ability of acting as a scavenger system for ROS; After Fenton reaction, NaOCl and lysozyme treatment, CTL hydrogels has better anti-degradation ability than HA hydrogels. [ 185 ] PEG BMP2 and sVEGFR1 Slow release In vivo Mice Stimulating differentiation of skeletal stem cells into cartilage. [ 53 ] Alginate / Poly (vinyl alcohol) Chondroitin sulfate and nanohydroxyapatite Slow release; Targeting In vivo Rabbits Promoting the formation of new matrix in cartilage defects, and the new matrix contain matrix, chondrocytes and osteoblasts with the characteristics of hyaline cartilage.…”

Section: Different Drug-delivery Systems For Intra-articular Injectio...mentioning

confidence: 99%

“…Therefore, some people have also improved the lubricating properties of hydrogels by modifying polymer materials. Sulfone-modified HA, 184 lactose modified chitosan 185 and gellan gum 186 could modulate viscoelastic properties of osteoarthritis synovial fluids and improve OA joint lubrication. Han et al 179 reported photocrosslinked methyl methacrylate gelatin (GelMA) hydrogel microspheres incorporated into a self-adhesive polymer (DMA-MPC) to prepare a new composite microsphere (GelMA@DMA-MPC).…”

Section: Different Drug-delivery Systems For Intra-articular Injectio...mentioning

confidence: 99%

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Knee Osteoarthritis Therapy: Recent Advances in Intra-Articular Drug Delivery Systems

Ma¹,

Zheng²,

Li³

et al. 2022

DDDT

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Drug delivery for osteoarthritis (OA) treatment is a continuous challenge because of their poor bioavailability and rapid clearance in joints. Intra-articular (IA) drug delivery is a common strategy and its therapeutic effects depend mainly on the efficacy of the drug-delivery system used for OA therapy. Different types of IA drug-delivery systems, such as microspheres, nanoparticles, and hydrogels, have been rapidly developed over the past decade to improve their therapeutic effects. With the continuous advancement in OA mechanism research, new drugs targeting specific cell/signaling pathways in OA are rapidly evolving and effective drug delivery is critical for treating OA. In this review, recent advances in various IA drug-delivery systems for OA treatment, OA targeted strategies, and related signaling pathways in OA treatment are summarized and analyzed based on current publications.

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Section: Different Drug-delivery Systems For Intra-articular Injectio...mentioning

confidence: 99%

Section: Different Drug-delivery Systems For Intra-articular Injectio...mentioning

confidence: 99%

Knee Osteoarthritis Therapy: Recent Advances in Intra-Articular Drug Delivery Systems

Ma¹,

Zheng²,

Li³

et al. 2022

DDDT

View full text Add to dashboard Cite

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“…Regarding the use of chitosan for viscosupplementation, Scognamiglio et al formulated hydrogels based on lactose-modified chitosan crosslinked with boric acid for the treatment of osteoarthritis [135]. One of the different compositions studied showed rheological properties similar to commercial products, so it was chosen for further characterization.…”

Section: Cartilage Regeneration and Viscosupplementationmentioning

confidence: 99%

“…Interestingly, this approach overcomes one of the main limitations of glues and patches, as the porous structure of freeze-dried chitosan allows the efficient permeation of gases and substances, thus enhancing the wound healing process [148]. Another approach was proposed by Zhu et al, who developed flurbiprofen-grafted chitosan/alginate composite-based 3D scaffolds for subcutaneous implantation [135]. These scaffolds were prepared by the lyophilization of a previously obtained gel and then grafted with crosslinkers and flurbiprofen.…”

Section: Soft Tissue Regenerationmentioning

confidence: 99%

Applications of Chitosan in Surgical and Post-Surgical Materials

et al. 2022

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The continuous advances in surgical procedures require continuous research regarding materials with surgical applications. Biopolymers are widely studied since they usually provide a biocompatible, biodegradable, and non-toxic material. Among them, chitosan is a promising material for the development of formulations and devices with surgical applications due to its intrinsic bacteriostatic, fungistatic, hemostatic, and analgesic properties. A wide range of products has been manufactured with this polymer, including scaffolds, sponges, hydrogels, meshes, membranes, sutures, fibers, and nanoparticles. The growing interest of researchers in the use of chitosan-based materials for tissue regeneration is obvious due to extensive research in the application of chitosan for the regeneration of bone, nervous tissue, cartilage, and soft tissues. Chitosan can serve as a substance for the administration of cell-growth promoters, as well as a support for cellular growth. Another interesting application of chitosan is hemostasis control, with remarkable results in studies comparing the use of chitosan-based dressings with traditional cotton gauzes. In addition, chitosan-based or chitosan-coated surgical materials provide the formulation with antimicrobial activity that has been highly appreciated not only in dressings but also for surgical sutures or meshes.

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“…This helical geometry is promoted by the connection in the gelano repeating unit. It is well known that gellan gum can form hydrogels, which consist of a threedimensional polymeric network that retains large amounts of water and are promising biomaterials in the treatment of joint degenerations [7,8] .…”

Section: Introductionmentioning

confidence: 99%

Chitosan-based hydrogel for treatment of temporomandibular joint arthritis

et al. 2021

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To produce polysaccharide-based hydrogels and cerium (Ce3+) doped hydroxyapatite plus chitosan and collagen to enable future applications in the treatment of joint degeneration. Hydrogel production and characterization were performed with Fourier transform infrared spectroscopy (FTIR), thermogravimetry analysis (TGA) and cytotoxicity testing with MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide]. A final biomaterial composition was Kelcogel® Gelana (58%), chitosan (22.3%), Ce3+ doped hydroxyapatite (10.7%) and bovine collagen (9%), or selected aspect material gelatinous physical color with whitish color and can be injected. The biomaterial composition was proven in the FTIR and TGA, which also provided the maximum supported temperature. In the MTT assay, despite the reduction in viability of the experimental group compared to the control group, cell viability remained approximately 90%. In the FTIR and TGA tests, the material composition was proven. The material does not present cytotoxic behavior for the MTT test, being an alternative for the treatment of joint diseases.

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A hydrogel system based on a lactose-modified chitosan for viscosupplementation in osteoarthritis

Cited by 24 publications

References 63 publications

Knee Osteoarthritis Therapy: Recent Advances in Intra-Articular Drug Delivery Systems

Knee Osteoarthritis Therapy: Recent Advances in Intra-Articular Drug Delivery Systems

Applications of Chitosan in Surgical and Post-Surgical Materials

Chitosan-based hydrogel for treatment of temporomandibular joint arthritis

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