A hydrogel spinal dural patch with potential anti-inflammatory, pain relieving and antibacterial effects

Li, Jiahao; Tian, Jingjing; Li, Chunxu; Chen, Longyun; Zhao, Yu

doi:10.1016/j.bioactmat.2022.01.043

Cited by 14 publications

(12 citation statements)

References 43 publications

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“…TNF‐ α and COX‐2 could be utilized to evaluate the inflammation response, cell growth control, and pain‐related neurotransmitter transmission. [ 60 ] We examined the expression of TNF‐ α and COX‐2 ( Figure a,b) of the zein/SDS‐P1 treated brain dural defect of rabbit using enzyme‐linked immunosorbent assay (ELISA) kit (mlbio, Shanghai). Pure CSF samples were first obtained by centrifugating (1000 g, 20 min) the collected CSF fluid from different groups (control group, fibrin glue treated group, and the zein/SDS‐P1 treated group) after treating for 1 week and 2 weeks, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…These results suggest that the zein/SDS-P1 can suppress inflammation and ease the pain. [60,61] Except for the sealing effect, the biochemical measurements of the blood routine (Table S1, Supporting Information) identified that all the basic parameters of the zein/SDS-P1 treated group stood in the normal range. We also detect the side effect of the zein/SDS-P1 adhesive on visceral organs of the rabbit models through H&E staining measurements.…”

Section: Sealing and Repairing The Brain Dural Defect Of Rabbitsmentioning

confidence: 99%

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Plant Protein‐Peptide Supramolecular Polymers with Reliable Tissue Adhesion for Surgical Sealing

Nie

Sun

Cheng

et al. 2023

Adv Healthcare Materials

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The fusion of protein science and peptide science opens up new frontiers in creating innovative biomaterials. Herein, a new kind of adhesive soft materials based on a natural occurring plant protein and short peptides via a simple co‐assembly route are explored. The hydrophobic zein is supercharged by sodium dodecyl sulfate to form a stable protein colloid, which is intended to interact with charge‐complementary short peptides via multivalent ionic and hydrogen bonds, forming adhesive materials at macroscopic level. The adhesion performance of the resulting soft materials can be fine‐manipulated by customizing the peptide sequences. The adhesive materials can resist over 78 cmH2O of bursting pressure, which is high enough to meet the sealing requirements of dural defect. Dural sealing and repairing capability of the protein‐peptide biomaterials are further identified in rat and rabbit models. In vitro and in vivo assays demonstrate that the protein‐peptide adhesive shows excellent anti‐swelling property, low cell cytotoxicity, hemocompatibility, and inflammation response. In particular, the protein‐peptide supramolecular biomaterials can in vivo dissociate and degrade within two weeks, which can well match with the time‐window of the dural repairing. This work underscores the versatility and availability of the supramolecular toolbox in the easy‐to‐implement fabrication of protein‐peptide biomaterials.

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Section: Resultsmentioning

confidence: 99%

Section: Sealing and Repairing The Brain Dural Defect Of Rabbitsmentioning

confidence: 99%

Plant Protein‐Peptide Supramolecular Polymers with Reliable Tissue Adhesion for Surgical Sealing

Nie

Sun

Cheng

et al. 2023

Adv Healthcare Materials

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“…For example, alginate saline gel was used to treat bone injury, heart injury, nerve injury, and periodontal injury. 212,213,247–250 We may be able to treat various body injuries more easily in the future with the excellent properties of alginate gel.…”

Section: Conclusion and Foresightmentioning

confidence: 99%

A review on the synthesis and development of alginate hydrogels for wound therapy

Cao

Cong

et al. 2023

J. Mater. Chem. B

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“…Microscopic examination of bioadhesives is needed to correlate their microstructure with their mechanical and biological properties. Techniques such as scanning electron microscopy (SEM), [ 215 ] cryo‐SEM, [ 216 ] confocal laser scanning microscopy, [ 79 ] atomic force microscopy [ 217 ] and transmission electron microscopy (especially for nanocomposite bioadhesives) [ 218 ] have been used for studying the microstructure of bioadhesives. Each technique of these has its advantages and limitations.…”

Section: Properties Of Antimicrobial Bioadhesives and Their Character...mentioning

confidence: 99%

Bioadhesives with Antimicrobial Properties

et al. 2023

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Bioadhesives with antimicrobial properties enable easier and safer treatment of wounds as compared to the traditional methods such as suturing and stapling on a variety of medical conditions. Composed of natural or synthetic polymers, these bioadhesives seal wounds and facilitate healing while preventing infections through the activity of locally released antimicrobial drugs, nanocomponents or inherently antimicrobial polymers. Although many different materials and strategies are employed to develop antimicrobial bioadhesives, the design of these biomaterials necessitates a prudent approach as achieving all the required properties including optimal adhesive and cohesive properties, biocompatibility, and antimicrobial activity can be challenging. Designing antimicrobial bioadhesives with tunable physical, chemical and biological properties will shed light on the path for future advancement of bioadhesives with antimicrobial properties. In this review, we discuss the requirements and commonly used strategies for developing bioadhesives with antimicrobial properties. In particular, we will summarize different methods for their synthesis and will review their experimental and clinical applications on a variety of organs. Advances in the design of bioadhesives with antimicrobial properties will pave the way for a better management of wounds to increase positive medical outcomes.This article is protected by copyright. All rights reserved

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A hydrogel spinal dural patch with potential anti-inflammatory, pain relieving and antibacterial effects

Cited by 14 publications

References 43 publications

Plant Protein‐Peptide Supramolecular Polymers with Reliable Tissue Adhesion for Surgical Sealing

Plant Protein‐Peptide Supramolecular Polymers with Reliable Tissue Adhesion for Surgical Sealing

A review on the synthesis and development of alginate hydrogels for wound therapy

Bioadhesives with Antimicrobial Properties

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