A hydrogel sealant for the treatment of severe hepatic and aortic trauma with a dissolution feature for post-emergent care

Konieczynska, Marlena D.; Villa-Camacho, Juan C.; Ghobril, Cynthia; Perez-Viloria, Miguel; Blessing, William A.; Nazarian, Ara; Rodriguez, Edward K.; Grinstaff, Mark W.

doi:10.1039/c6mh00378h

Cited by 27 publications

(20 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Active agents aimed at expediting the clotting, such as proteins (thrombin, fibrinogen, collagen, gelatin) and polysaccharides (chitosan, oxidized cellulose), are commonly introduced into hemostasis materials . In situ formation of hydrogels to stem bleeding provides another effective approach . For various kinds of wounds, the baseline emergency treatment is using hemostatic dressings to pack the wounds and bind under pressure .…”

mentioning

confidence: 99%

“…The results demonstrate that the unnecessary blood loss due to the superhydrophilicity of the traditional hemostatic fabrics can be avoided by integrating superhydrophilicity and superhydrophobicity in the composite fabrics. As opposed to the reported strategies using various external factors to realize the effective hemostasis, our method depends on the autologous blood coagulation mechanism.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Superhydrophobic/Superhydrophilic Janus Fabrics Reducing Blood Loss

Zhu

Zhao

et al. 2018

Adv Healthcare Materials

106

View full text Add to dashboard Cite

Hemostatic fabrics are most commonly used in baseline emergency treatment; however, the unnecessary blood loss due to the excessive blood absorption by traditional superhydrophilic fabrics is overlooked. Herein, for the first time, superhydrophobic/superhydrophilic Janus fabrics (superhydrophobic on one side and superhydrophilic on the other) are proposed: the superhydrophilic part absorbs water in the blood to expedite the clotting while the superhydrophobic part prevents blood from further permeating. Compared with the common counterparts, effective bleeding control with reducing blood loss more than 50% can be achieved while the breathability largely remain by using Janus fabrics. The proposed prototypes can even prolong the survival time in the rat model with serious bleeding. This strategy for reducing blood loss via simply tuning wettability is promising for the practical applications.

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

Superhydrophobic/Superhydrophilic Janus Fabrics Reducing Blood Loss

Zhu

Zhao

et al. 2018

Adv Healthcare Materials

106

View full text Add to dashboard Cite

show abstract

“…24 Recent research efforts have been focused on embedding such particles into hydrogels, 25,26 to build oxygen sensing, drug-releasing materials. By incorporating oxygen-sensing phosphors into a hydrogel burn dressing developed by the Grinstaff lab at Boston University, [27][28][29] oxygenation measurements can now be performed on complex wound topologies in transudating/ exudating wound beds. Efforts focused on incorporating drugloaded nanoparticles into this dressing formulation will enable on-demand drug release in the near-future.…”

Section: Clinical Study: Acute Inflammation (2017)mentioning

confidence: 99%

Sensing, monitoring, and release of therapeutics: the translational journey of next generation bandages

Marks

Evans

et al. 2018

J. Biomed. Opt.

View full text Add to dashboard Cite

This article aims to be a progress report on the Sensing, Monitoring And Release of Therapeutics (SMART) bandage-one of the three technologies that received the inaugural SPIE Photonics West Translational Research Symposium Award in 2015. Invented and developed by Dr. Conor L. Evans and his research team at the Wellman Center for Photomedicine, Massachusetts General Hospital, the SMART bandage is a tool aiming to provide measurements of physiological parameters in the skin alongside the administration of therapeutics on-demand. Since the project began in 2012, the chemists, physicists, and biomedical engineers in the team have worked closely with partners from academia and industry to develop oxygen-sensing SMART bandage prototypes that are now in first-inhuman clinical studies. This report gives perspectives on the genesis and translational journey of the technology with an emphasis on the challenges encountered, and the solutions innovated at each stage of development.

show abstract

“…17 Hemorrhage is the leading cause of preventable death after traumatic injury. 18 Compressible hemorrhage can normally be stopped using constant and direct manual pressure with a tourniquet.…”

Section: Thiol–thioester Exchangementioning

confidence: 99%

On-Demand Dissolution of Chemically Cross-Linked Hydrogels

2017

Self Cite

View full text Add to dashboard Cite

Conspectus The formation and subsequent on-demand dissolution of chemically cross-linked hydrogels is of keen interest to chemists, engineers, and clinicians. In this Account, we summarize our recent advances in the area of dissolvable chemically cross-linked hydrogels and provide a comparative discussion of other recent hydrogel systems. Using biocompatible macromonomers, we developed a library of cross-linked dendritic hydrogels that possess favorable properties, including biocompatibility, tissue adhesion, and swelling. Additionally, these hydrogels possess the unique ability to dissolve on-demand via application of a biocompatible aqueous solution. Each of the three hydrogel systems described employs a thiol–thioester exchange reaction as the mechanism of dissolution. These new materials successfully decrease bleeding in in vivo models of hepatic and aortic hemorrhage and dissolve on-demand, providing easy removal. In addition, we evaluated these hydrogels as dressings for second-degree burn wounds and performed proof-of-concept in vivo studies. These hydrogel wound dressings provide a means of repeatedly changing the dressing in a minimally invasive and atraumatic manner while also serving as a protective barrier against bacterial infection. Finally, we highlight the seminal work of other researchers in the field of dissolvable chemically cross-linked hydrogels using thiol–disulfide exchange, retro-Michael-type, and retro-Diels–Alder reactions. These chemistries provide a versatile synthetic toolbox to dissolve hydrogels in a controlled manner on time scales from minutes to weeks. Continued investigation of these dissolution approaches as well as the development of new chemical reactions will open doors to other avenues of on-demand dissolution and expand the application space for these materials. In summary, the management and closure of wounds after traumatic injury or surgical intervention are of significant clinical importance. Stimuli-responsive hydrogels that function as sealants, adhesives, or dressings are emerging as vital alternatives to current standards of care that rely upon conventional sutures, staples, or dressings.

show abstract

A hydrogel sealant for the treatment of severe hepatic and aortic trauma with a dissolution feature for post-emergent care

Abstract: On-demand dissolvable hydrogel sealant reduces blood loss significantly in in vivo animal models of non-compressible hemorrhage.

Cited by 27 publications

References 49 publications

Superhydrophobic/Superhydrophilic Janus Fabrics Reducing Blood Loss

Superhydrophobic/Superhydrophilic Janus Fabrics Reducing Blood Loss

Sensing, monitoring, and release of therapeutics: the translational journey of next generation bandages

On-Demand Dissolution of Chemically Cross-Linked Hydrogels

Contact Info

Product

Resources

About