A hydralazine-induced triumvirate: Lupus, cutaneous vasculitis, and cryptococcoid Sweet syndrome

Skaljic, Meliha; Agarwal, Ashwin; Smith, Robert J.; Nguyen, Cuong; Xu, Xiaowei; Shahane, Anupama; Degnan, Kathleen; Greenblatt, Jeff; Rosenbach, Misha

doi:10.1016/j.jdcr.2019.08.020

Cited by 7 publications

(22 citation statements)

References 6 publications

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“…Iododerma after intravenous iodinated contrast in a patient receiving hydralazine has been previously reported. 14 In addition, a patient with hydralazine-induced autoimmune syndrome, chronic kidney disease, vasculitis, and cryptococcoid-like Sweet syndrome has been recently described 15 ; however, there was no mention of iodine levels. In patients with impaired renal function, iodinated contrast media and the concurrent use of hydralazine may confer an increased risk of iodine toxicity.…”

Section: Discussionmentioning

confidence: 99%

Iodine toxicity after iodinated contrast: New observations in iododerma

et al. 2020

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Section: Discussionmentioning

confidence: 99%

Iodine toxicity after iodinated contrast: New observations in iododerma

et al. 2020

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“…Leukopenia was also observed in these patients [ 156 ]. Hydralazine appears to be the drug most recently and often reported that report both anti-MPO and ANAs [ [157] , [158] , [159] ]. The role of anti-MPO antibodies in either idiopathic SLE or drug-induced lupus is considered to involve mechanisms that activate neutrophils leading to the NET formation and tissue damage.…”

Section: Mpo Usefulness As a Biomarker In Disease Statesmentioning

confidence: 99%

The many roles of myeloperoxidase: From inflammation and immunity to biomarkers, drug metabolism and drug discovery

Siraki

2021

Redox Biology

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This review provides a practical guide to myeloperoxidase (MPO) and presents to the reader the diversity of its presence in biology. The review provides a historical background, from peroxidase activity to the discovery of MPO, to its role in disease and drug development. MPO is discussed in terms of its necessity, as specific individuals lack MPO expression. An underlying theme presented throughout brings up the question of the benefit and burden of MPO activity. Enzyme structure is discussed, including accurate masses and glycosylation sites. The catalytic cycle of MPO and its corresponding pathways are presented, with a discussion of the importance of the redox couples of the different states of MPO. Cell lines expressing MPO are discussed and practically summarized for the reader, and locations of MPO (primary and secondary) are provided. Useful methods of MPO detection are discussed, and how these can be used for studying disease processes are implied through the presentation of MPO as a biomarker. The presence of MPO in neutrophil extracellular traps is presented, and the activators of the former are provided. Lastly, the transition from drug metabolism to a target for drug development is where the review concludes.

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“…We speculate whether all these cases could actually have been iododerma presenting with CND because of the uncanny overlap of similarities in the disease course with iododerma, together with concurrent risk factors and probable radiocontrast media exposure. Unfortunately, urine/serum iodine levels were not available in these cases 7,9–14 …”

Section: Discussionmentioning

confidence: 99%

Acute iododerma presenting as cryptococcoid neutrophilic dermatosis: A clinicopathological pitfall and interesting findings gleaned from a review of the literature

Liang

See

2022

J Cutan Pathol

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Iododerma is an uncommon dermatosis caused by excessive iodine exposure and is associated with significant morbidity and mortality. Because of its heterogenous clinical presentation and variable histopathological findings, which depend on the time the skin biopsy is performed, the diagnosis of iododerma is often delayed. We report a rare case of acute iododerma in a woman with end‐stage diabetic nephropathy with antecedent radioiodine contrast exposure, presenting histopathologically as cryptococcoid neutrophilic dermatosis (CND). We underscore important clinicopathological pitfalls to avoid misdiagnosis with similar overlapping entities such as Sweet syndrome, review all published cases of CND and draw novel insights into its associated entities.

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A hydralazine-induced triumvirate: Lupus, cutaneous vasculitis, and cryptococcoid Sweet syndrome

Cited by 7 publications

References 6 publications

Iodine toxicity after iodinated contrast: New observations in iododerma

Iodine toxicity after iodinated contrast: New observations in iododerma

The many roles of myeloperoxidase: From inflammation and immunity to biomarkers, drug metabolism and drug discovery

Acute iododerma presenting as cryptococcoid neutrophilic dermatosis: A clinicopathological pitfall and interesting findings gleaned from a review of the literature

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