A Hybrid Nanoparticle Probe for Dual‐Modality Positron Emission Tomography and Magnetic Resonance Imaging

Choi, Jin Woo; Park, Jeong Chan; Nah, Hyunsoo; Woo, Sung-Ho; Oh, Jong–Hoon; Kim, Kyeong Min; Cheon, Gi Jeong; Chang, Yongmin; Yoo, Jeongsoo; Cheon, Jinwoo

doi:10.1002/anie.200801369

Cited by 194 publications

(127 citation statements)

References 33 publications

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“…[1], [20], [21], [22], [23] and [24]. Chen and coworkers reported nanoparticle-based probe for dual-modality PET/MRI, by using MnMEIO as MRI agent and 124 I for PET [25]. There is increasing interest in the development of nontraditional positron-emitting radionuclides [26] and [27].…”

Section: Introductionmentioning

confidence: 99%

The cell labeling efficacy, cytotoxicity and relaxivity of copper-activated MRI/PET imaging contrast agents

et al. 2011

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/npsi/ctrl?action=rtdoc&an=19739632&lang=en http://nparc.cisti-icist.nrc-cnrc.gc.ca/npsi/ctrl?action=rtdoc&an=19739632&lang=fr READ THESE TERMS AND CONDITIONS CAREFULLY BEFORE USING THIS WEBSITE.http://nparc.cisti-icist.nrc-cnrc.gc.ca/npsi/jsp/nparc_cp.jsp?lang=en Vous avez des questions? Nous pouvons vous aider. Pour communiquer directement avec un auteur, consultez la première page de la revue dans laquelle son article a été publié afin de trouver ses coordonnées. Si vous n'arrivez pas à les repérer, communiquez avec nous à PublicationsArchive-ArchivesPublications@nrc-cnrc.gc.ca. Questions?Contact the NRC Publications Archive team at PublicationsArchive-ArchivesPublications@nrc-cnrc.gc.ca. If you wish to email the authors directly, please see the first page of the publication for their contact information. NRC Publications Archive Archives des publications du CNRCThis publication could be one of several versions: author's original, accepted manuscript or the publisher's version. / La version de cette publication peut être l'une des suivantes : la version prépublication de l'auteur, la version acceptée du manuscrit ou la version de l'éditeur. For the publisher's version, please access the DOI link below./ Pour consulter la version de l'éditeur, utilisez le lien DOI ci-dessous.http://doi.org/10.1016/j.biomaterials.2010.10.013 Biomaterials, 32, 4, pp. 1167Biomaterials, 32, 4, pp. -1176Biomaterials, 32, 4, pp. , 2010 The cell labeling efficacy, cytotoxicity and relaxivity of copperactivated MRI/PET imaging contrast agents AbstractA new class of nanoparticle-based dual-modality positron emission tomography/magnetic resonance imaging (PET/MRI) contrast agents has been developed. The probe consists of a superparamagnetic iron oxide (SPIO) or manganese oxide core coated with 3,4-dihydroxy-d,l-phenylalanine (dl-DOPA). The chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) was conjugated to DOPA termini. The DOTA modified nanoparticles allow chelation of copper for PET imaging. These surface functionalized nanoparticle-based probes have been characterized by various analytical techniques. The cell-labeling efficacy, cytotoxicity and relaxivity of these nanoparticles have been evaluated and compared with the same properties of one of the most commonly utilized MRI contrast agents, Feridex ® . Evidently, this new nanoparticle has a great potential for use in cell tracking with MRI and PET in the absence of transfecting agent. It is noteworthy that there is a sharp increase in r 2 relaxivity of these nanoparticles on coordination with Cu 2+ ions. Thus these iron oxide nanoparticles can also be explored as the smart magnetic resonance (MR) sensor for the detection of micromolar changes in copper concentration for neurodegenerative diseases such as Alzheimer's disease, Menkes and Wilson's diseases, amyotrophic lateral sclerosis and prion diseases.

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Section: Introductionmentioning

confidence: 99%

The cell labeling efficacy, cytotoxicity and relaxivity of copper-activated MRI/PET imaging contrast agents

et al. 2011

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“…In one notable study performed by choi et al, [783] 124 I radionuclides were conjugated on Mn-doped ferrite nanoparticles coated by serum albumin (Figure 46a). They were applied as PET/MRI dual imaging agents and precisely delineated small sentinel lymph nodes.…”

Section: Positron Emission Tomographymentioning

confidence: 98%

“…However, technological challenges in operating MRI/ SPECT dual imaging simultaneously are perhaps the reason why this technique is still in its infancy and has somewhat [783] b) Reproduced with permission. [785] Copyright 2016, the authors, published under CC-BY-NC-ND license.…”

Section: Single Photon Emission Computer Tomographymentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

187

171

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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

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“…To address this, regulations specifically governing the current good manufacturing practice of PET radiotracers have been developed in recent years. [10][11][12] To achieve the best contrast for PET imaging, several key issues need to be taken into consideration, such as how to choose the appropriate isotopes as positron emitters and nanoparticles as radiotracers, what chemical reactions can be utilized to improve the labeling efficiency, and how to functionalize the nanoparticles. 13 Nanomaterials have unique properties, and have attracted considerable interest in biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Nano-graphene oxide composite for in vivo imaging

Jang¹,

Kang²,

Lee³

et al. 2018

IJN

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Introduction Positron emission tomography (PET) tracers has the potential to revolutionize cancer imaging and diagnosis. PET tracers offer non-invasive quantitative imaging in biotechnology and biomedical applications, but it requires radioisotopes as radioactive imaging tracers or radiopharmaceuticals. Method This paper reports the synthesis of 18 F-nGO-PEG by covalently functionalizing PEG with nano-graphene oxide, and its excellent stability in physiological solutions. Using a green synthesis route, nGO is then functionalized with a biocompatible PEG polymer to acquire high stability in PBS and DMEM. Results and discussion The radiochemical safety of 18 F-nGO-PEG was measured by a reactive oxygen species and cell viability test. The biodistribution of 18 F-nGO-PEG could be observed easily by PET, which suggested the significantly high sensitivity tumor uptake of 18 F-nGO-PEG and in a tumor bearing CT-26 mouse compared to the control. 18 F-nGO-PEG was applied successfully as an efficient radiotracer or drug agent in vivo using PET imaging. This article is expected to assist many researchers in the fabrication of 18 F-labeled graphene-based bio-conjugates with high reproducibility for applications in the biomedicine field.

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A Hybrid Nanoparticle Probe for Dual‐Modality Positron Emission Tomography and Magnetic Resonance Imaging

Cited by 194 publications

References 33 publications

The cell labeling efficacy, cytotoxicity and relaxivity of copper-activated MRI/PET imaging contrast agents

The cell labeling efficacy, cytotoxicity and relaxivity of copper-activated MRI/PET imaging contrast agents

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Nano-graphene oxide composite for in vivo imaging

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