A hybrid membrane coating nanodrug system against gastric cancer <i>via</i> the VEGFR2/STAT3 signaling pathway

Long, Ying; Zhou, Wang; Fan, Jialong; Yuan, Liqin; Tong, Chunyi; Zhao, Yanzhong; Liu, Bin

doi:10.1039/d1tb00029b

Cited by 25 publications

(21 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cinobufagin (CS-1), a bufanolide steroid secreted by the Asiatic toad Bufo gargarizans, is one of the important ingredients in the anti-cancer Chinese medicine of Chansu [18]. This compound evoked strong anti-tumor effects through IL-6/ STAT3, PI3K/Akt, and MAPK pathways [19]. In addition, it can increase intracellular ROS and reduce reduced glutathione (GSH) levels by inhibiting glutathione reductase (GR) [20].…”

Section: Introductionmentioning

confidence: 99%

Bio-nanocomplexes with autonomous O2 generation efficiently inhibit triple negative breast cancer through enhanced chemo-PDT

et al. 2022

Self Cite

View full text Add to dashboard Cite

As one kind of aggressive cancer, triple-negative breast cancer (TNBC) has become one of the major causes of women mortality worldwide. Recently, combinational chemo-PDT therapy based on nanomaterials has been adopted for the treatment of malignant tumor. However, the efficacy of PDT was partly compromised under tumor hypoxia environment due to the lack of sustainable O2 supply. In this study, CeO2-loaded nanoparticles (CeNPs) with peroxidase activity were synthesized to autonomously generate O2 by decomposing H2O2 within tumor region and reprogramming the hypoxia microenvironment as well. Meanwhile, the compound cinobufagin (CS-1) was loaded for inhibiting TNBC growth and metastasis. Moreover, the hybrid membrane camouflage was adopted to improve the biocompatibility and targeting ability of nanocomplexes. In vitro assay demonstrated that decomposition of H2O2 by CeO2 achieved sustainable O2 supply, which accordingly improved the efficacy of PDT. In turn, the generated O2 improved the cytotoxicity and anti-tumor migration effect of CS-1 by downregulating HIF-1α and MMP-9 levels. In vivo assay demonstrated that the combination of CS-1 and PDT significantly inhibited the growth and distance metastasis of tumor in MDA-MB-231 bearing mice. Thus, this chemo-PDT strategy achieved satisfactory therapeutic effects by smartly utilizing the enzyme activity of nanodrugs and special micro-environment of tumor.

show abstract

Section: Introductionmentioning

confidence: 99%

Bio-nanocomplexes with autonomous O2 generation efficiently inhibit triple negative breast cancer through enhanced chemo-PDT

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…Elion et al described that SLR20 NP treatment inhibits tumour growth and metastasis by inducing pyroptosis and intrinsic apoptosis in breast cancer [ 137 ]. The constructed nanocomplex LP-R/C@AC eliminates gastric cancer cell growth by inducing pyroptosis [ 138 ]. Therefore, with the development of nanotechnology, we can apply nanomaterials as carriers for chemotherapeutic drugs or pyroptosis-related recombinant proteins to trigger pyroptosis and reduce the toxic effects of chemotherapy drugs.…”

Section: Pyroptosis and Nanomaterialsmentioning

confidence: 99%

Emerging mechanisms of pyroptosis and its therapeutic strategy in cancer

Zhang

Tan

et al. 2022

Cell Death Discov.

View full text Add to dashboard Cite

Pyroptosis, a type of inflammatory programmed cell death, is triggered by caspase cleavage of gasdermin family proteins. Based on accumulating evidence, pyroptosis is closely associated with tumour development, but the molecular mechanism underlying pyroptosis activation and the signalling pathways regulated by pyroptosis remain unclear. In this review, we first briefly introduce the definition, morphological characteristics, and activation pathways of pyroptosis and the effect of pyroptosis on anticancer immunity. Then we review recent progress concerning the complex role of pyroptosis in various tumours. Importantly, we summarise various FDA-approved chemotherapy drugs or natural compounds that exerted antitumor properties by inducing pyroptosis of cancer cells. Moreover, we also focus on the current application of nanotechnology-induced pyroptosis in tumour therapy. In addition, some unsolved problems and potential future research directions are also raised.

show abstract

“…In addition, it showed stronger antitumor activity in a mouse model of gastric cancer compared to a single agent. Emerging nanotechnology offers an alternative approach to building novel drug delivery systems with high targeting capability and solubility ( 81 ). In the Zhang et al.…”

Section: Gastric Cancer and Nanomaterialsmentioning

confidence: 99%

New Advances in Nano-Drug Delivery Systems: Helicobacter pylori and Gastric Cancer

Zhu

Wang

et al. 2022

Front. Oncol.

View full text Add to dashboard Cite

With the development of materials science and biomedicine, the application of nanomaterials in the medical field is further promoted. In the process of the diagnosis and treatment of diseases, a variety of drugs need to be used. It is an ideal state to make these drugs arrive at a specific location at a specific time and release at a specific speed, which can improve the bioavailability of drugs and reduce the adverse effects of drugs on normal tissues. Traditional drug delivery methods such as tablets, capsules, syrups, and ointments have certain limitations. The emergence of a new nano-drug delivery system further improves the accuracy of drug delivery and the efficacy of drugs. It is well known that the development of the cancer of the stomach is the most serious consequence for the infection of Helicobacter pylori. For the patients who are suffering from gastric cancer, the treatments are mainly surgery, chemotherapy, targeted and immune therapy, and other comprehensive treatments. Although great progress has been made, the diagnosis and prognosis of gastric cancer are still poor with patients usually diagnosed with cancer at an advanced stage. Current treatments are of limited benefits for patients, resulting in a poor 5-year survival rate. Nanomaterials may play a critical role in early diagnosis. A nano-drug delivery system can significantly improve the chemotherapy, targeted therapy, and immunotherapy of advanced gastric cancer, reduce the side effects of the original treatment plan and provide patients with better benefits. It is a promising treatment for gastric cancer. This article introduces the application of nanomaterials in the diagnosis and treatment of H. pylori and gastric cancer.

show abstract

A hybrid membrane coating nanodrug system against gastric cancer via the VEGFR2/STAT3 signaling pathway

Abstract: Although drug combination has been proved to be an efficient strategy for clinic gastric cancer therapy, how to further improve their bioavailability and reduce the side effects are still challenges...

Cited by 25 publications

References 40 publications

Bio-nanocomplexes with autonomous O2 generation efficiently inhibit triple negative breast cancer through enhanced chemo-PDT

Bio-nanocomplexes with autonomous O2 generation efficiently inhibit triple negative breast cancer through enhanced chemo-PDT

Emerging mechanisms of pyroptosis and its therapeutic strategy in cancer

New Advances in Nano-Drug Delivery Systems: Helicobacter pylori and Gastric Cancer

Contact Info

Product

Resources

About