Transportation projects are generally large, with limited resources and highly interdependent activities. The complexities and interdependencies apparent in large transportation projects have prohibited effective application of management science and economics methods to these problems. We propose a heuristic method with several hybrid components. We formulate the problem as a Travelling Salesman Problem (TSP). A Neural Network (NN) is used to cope with the interdependency concerns. An algorithm with an iterative process is confined to search for the longest path (most benefit or most reduction in the user-time) in the NN as a solution to the TSP. The solution from each iteration step is utilised to update and train the NN and enhance its prediction. A search engine inspired by the concept of Ant Colony (AC) and hybridised with Genetic Algorithm (GA) is developed to find a suitable solution to the TSP. The hybrid heuristic method proposed in this study is applied to the real data for the city of Winnipeg in Canada to demonstrate the applicability of the proposed framework and exhibit the efficacy of the procedures and algorithms.Reference to this paper should be made as follows: Bagloee, S.A. and Tavana, M. (2012) 'An efficient hybrid heuristic method for prioritising large transportation projects with interdependent activities', Int.Biographical notes: Saeed Asadi Bagloee is a Senior Transportation Planner and lead modeller at Parsons Overseas Limited in Dubai, UAE. He received his BS in Civil Engineering from Khaje Nasir Toosi University of Technology and his MS in Transportation Planning and Engineering from Sharif University of Technology in Tehran, Iran. His research interest is transportation planning and modelling including travel demand forecasting, traffic impact studies, road network design and transit planning and economic analysis of transportation projects. He has conducted extensive research at the Institute for Transportation Studies and Research at Sharif University of Technology and has presented and published his research in several international conferences and proceedings.