A hybrid electrically-and-piezoelectrically driven micromixer built on paper for microfluids mixing

Guan, Yanfang; Xu, Fengqian; Sun, Baichuan; Meng, Xiangxi; Liu, Yansheng; Bai, Mingyang

doi:10.1007/s10544-020-00502-7

Cited by 10 publications

(6 citation statements)

References 37 publications

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“…In this device, a transducer placed at the end of the channel atomizes the fluid and creates negative pressure, increasing the mixing performance. Guan et al assessed two external devices, a DC electric device and a piezoelectric transducer (PZT), to improve mixing efficiency in a zigzag-shaped paper channel . They found that increased DC voltage accelerates ion movement in a KCl solution and thus improves the mixing performance.…”

Section: Device Designs and Modificationsmentioning

confidence: 99%

“…Guan et al assessed two external devices, a DC electric device and a piezoelectric transducer (PZT), to improve mixing efficiency in a zigzag-shaped paper channel. 157 They found that increased DC voltage accelerates ion movement in a KCl solution and thus improves the mixing performance. Also, the low frequency of the PZT causes the flow to vibrate easily with the fluidity of the liquids, enhancing the mixing effect.…”

Section: Mixingmentioning

confidence: 99%

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Microfluidic Paper-Based Analytical Devices: From Design to Applications

et al. 2021

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Microfluidic paper-based analytical devices (μPADs) have garnered significant interest as a promising analytical platform in the past decade. Compared with traditional microfluidics, μPADs present unique advantages, such as easy fabrication using established patterning methods, economical cost, ability to drive and manipulate flow without equipment, and capability of storing reagents for various applications. This Review aims to provide a comprehensive review of the field, highlighting fabrication methods available to date with their respective advantages and drawbacks, device designs and modifications to accommodate different assay needs, detection strategies, and the growing applications of μPADs. Finally, we discuss how the field needs to continue moving forward to realize its full potential.

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Section: Device Designs and Modificationsmentioning

confidence: 99%

Section: Mixingmentioning

confidence: 99%

Microfluidic Paper-Based Analytical Devices: From Design to Applications

et al. 2021

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“…Acoustic waves can be divided into surface acoustic waves (SAWs) and bulk acoustic waves (BAWs). Most existing studies related to μPADs integrated with acoustics are based on SAWs. − Despite SAWs having higher energy density than BAWs at the same power, the fabrication of SAW microfluidic devices is much more complex and expensive than BAW microfluidic devices.…”

Section: Introductionmentioning

confidence: 99%

Acoustofluidics-Assisted Multifunctional Paper-Based Analytical Devices

Zhao,

Ding,

Chen

et al. 2023

Anal. Chem.

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Microfluidic paper-based analytical devices (μPADs) feature an economic and sensitive nature, while acoustofluidics displays contactless and versatile virtue, and both of them gained tremendous interest in the past decades. Integrating μPADs with acoustofluidic techniques provides great potential to overcome the inherent shortcomings and make appealing achievements. Here, we present acoustofluidics-assisted multifunctional paper-based analytical devices that leverage bulk acoustic waves to realize multiple applications on paper substrates, including uniform colorimetric detection, microparticle/cell enrichment, fluorescence amplification, homogeneous mixing, and nanomaterial synthesis. The glucose detection in the range of 5−15 mM was conducted to perform uniform colorimetric detection. Various types (brass powder, copper powder, diamond powder, and yeast cells) and sizes (5−200 μm) of solid particles and biological cells can be enriched on paper in a few seconds or minutes; thus, fluorescence amplification by 3 times was realized with the enrichment. The high-throughput and homogeneous mixing of two fluids can be achieved, and based on the mixing, nanomaterials (ZnO nanosheets) were synthesized on paper. We analyzed the underlying mechanisms of these applications in the devices, which are attributed to Faraday waves and Chladni patterns. With their simple fabrication and prominent effectiveness, the devices open up new possibilities for paper-based microfluidic devices.

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“…17−20 Active micromixers have the advantages of high mixing efficiency, good mixing effect, and short channel length. 21 Some external energy sources require contact with the fluid, which disturbs the fluid. This may contaminate the fluid or cause biochemical reactions.…”

Section: Introductionmentioning

confidence: 99%

“…Active micromixers mainly rely on external energy input to promote fluid mixing. External energy sources include electric, magnetic, and acoustic fields. − Active micromixers have the advantages of high mixing efficiency, good mixing effect, and short channel length . Some external energy sources require contact with the fluid, which disturbs the fluid.…”

Section: Introductionmentioning

confidence: 99%

Novel Study on the Mixing Mechanism of Active Micromixers Based on Surface Acoustic Waves

Chen

2022

Ind. Eng. Chem. Res.

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The method of using a surface acoustic wave (SAW) to drive fluid mixing on a microfluidic chip has been widely investigated by researchers because of its advantages of not directly contacting the fluid and not changing the chemical properties of the fluid. In this paper, we investigate the potential mechanism of SAW-driven fluid mixing. A SAW device is designed by us and modal and harmonic response analyses are performed on it. Because the mechanisms of the traveling SAW (TSAW) and the standing SAW (SSAW) on a fluid are different, we have performed transient simulations for each of them in order to clearly understand their differences. The effect of voltage values on the intensity of acoustic pressure is also studied by us. Finally, we perform a comprehensive analysis of acoustic-fluid force-driven fluid mixing. For TSAW- and SSAW-driven fluid mixing, we discuss and analyze the mixing effect at different voltages separately. The velocity fields of the two types of SAW-driven micromixers are also investigated. It is found that the mixing effect of both micromixers is enhanced with increasing voltage. However, the TSAW-driven micromixer produces a single vortex flow through the channel in the acoustic action region, while the SSAW-driven micromixer produces a symmetric double vortex flow. The difference between the TSAW- and SSAW-driven fluids can be clearly analyzed by the velocity field results. The TSAW drives the fluid mainly on one side of the microchannel, while the SSAW drives the fluid by superposition of the acoustic flow force on both sides of the microchannel. The results of this study contribute to a better understanding of the SAW-driven effect on the flow properties of fluids. Moreover, this work lays a theoretical foundation for practical applications in areas such as biochemical reactions and polymer synthesis.

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A hybrid electrically-and-piezoelectrically driven micromixer built on paper for microfluids mixing

Cited by 10 publications

References 37 publications

Microfluidic Paper-Based Analytical Devices: From Design to Applications

Microfluidic Paper-Based Analytical Devices: From Design to Applications

Acoustofluidics-Assisted Multifunctional Paper-Based Analytical Devices

Novel Study on the Mixing Mechanism of Active Micromixers Based on Surface Acoustic Waves

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