Purpose: This study presents a systematic literature review that provides a broad and holistic view of how machine learning can be used and integrated to enhance decision-making in various areas of the supply chain, highlighting its combination with other techniques and models.Design/methodology/approach: An exhaustive literature review used three sets of keywords in the Scopus and Web of Science (WoS) databases. Through a rigorous filtering process, 70 articles were selected from an initial total of 410, focusing on those that specifically addressed the intersection of machine learning and decision-making in supply chain management.Findings: Machine learning has proven to be an essential tool in the supply chain, with applications in inventory management, logistics, and transportation, among others. Its integration with other techniques has led to significant advances in decision-making, improving efficiency in complex environments. Combining machine learning methods with traditional techniques has been particularly effective, and integration with emerging technologies has opened up new application possibilities.Originality/value: Unlike previous studies that focused on specific areas, this study offers a broad perspective on the application of machine learning in the supply chain. Additionally, combining machine learning techniques with other models is highlighted, representing added value for the scientific community and suggesting new avenues for future research.