Based on the Greek term monolithos (stone consisting of one single block) Kallrath (Comput Chem Eng 33:1983-1993, 2009) introduced the term polylithic for modeling and solution approaches in which mixed integer or non-convex nonlinear optimization problems are solved by tailor-made methods involving several models and/or algorithmic components, in which the solution of one model is input to another one. This can be exploited to initialize certain variables, or to provide bounds on them (problem-specific preprocessing). Mathematical examples of polylithic approaches are decomposition techniques, or hybrid methods in which constructive heuristics and local search improvement methods are coupled with exact MIP algorithms. Tailormade polylithic solution approaches with thousands or millions of solve statements are challenges on algebraic modeling languages. Local objects and procedural structures are almost necessary. Warm-start and hot-start techniques can be essential. The effort of developing complex tailor-made polylithic solutions is awarded by enabling us to solve real-world problems far beyond the limits of monolithic approaches and general purpose solvers.