A hyaluronic acid modified cuprous metal-organic complex for reversing multidrug resistance via redox dyshomeostasis

Wan, Yichen; Chen, Zelong; Wang, Yi; Zhao, Wenkang; Pei, Zhichao; Pu, Liang; Lv, Yinghua; Li, Jiaxuan; Li, Jiahui; Pei, Yuxin

doi:10.1016/j.carbpol.2023.120762

Cited by 11 publications

(4 citation statements)

References 52 publications

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“…In addition to cationic polymers, metal ions can also be used as crosslinkers to form HA nanogels by coordinating with the functional groups on the HA backbone. For example, HA nanogels were physically formed by coating positively charged 3-thiol-1,2,4-triazole-based copper complexes [ 24 ]. 3-Thiol-1,2,4-triazole is an organic linker with triazole groups that function as bidentate ligands for Cu 2+ and thiol groups that can be cleaved in the high reducing environment inside tumor cells.…”

Section: Hyaluronic Acid Nanogelmentioning

confidence: 99%

Hyaluronic Acid Nanogels: A Promising Platform for Therapeutic and Theranostic Applications

Myint,

Laomeephol,

Thamnium

et al. 2023

Pharmaceutics

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Hyaluronic acid (HA) nanogels are a versatile class of nanomaterials with specific properties, such as biocompatibility, hygroscopicity, and biodegradability. HA nanogels exhibit excellent colloidal stability and high encapsulation capacity, making them promising tools for a wide range of biomedical applications. HA nanogels can be fabricated using various methods, including polyelectrolyte complexation, self-assembly, and chemical crosslinking. The fabrication parameters can be tailored to control the physicochemical properties of HA nanogels, such as size, shape, surface charge, and porosity, enabling the rational design of HA nanogels for specific applications. Stimulus-responsive nanogels are a type of HA nanogels that can respond to external stimuli, such as pH, temperature, enzyme, and redox potential. This property allows the controlled release of encapsulated therapeutic agents in response to specific physiological conditions. HA nanogels can be engineered to encapsulate a variety of therapeutic agents, such as conventional drugs, genes, and proteins. They can then be delivered to target tissues with high efficiency. HA nanogels are still under development, but they have the potential to become powerful tools for a wide range of theranostic or solely therapeutic applications, including anticancer therapy, gene therapy, drug delivery, and bioimaging.

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Section: Hyaluronic Acid Nanogelmentioning

confidence: 99%

Hyaluronic Acid Nanogels: A Promising Platform for Therapeutic and Theranostic Applications

Myint,

Laomeephol,

Thamnium

et al. 2023

Pharmaceutics

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“…P-gp overexpression reduces intracellular drug concentrations and cytotoxicity by using its efflux pump function to expel cisplatin ( 20 ), paclitaxel ( 22 ), 5-fluorouracil (5-Fu) ( 23 ), doxorubicin (DOX) ( 24 ) and other chemotherapeutic drugs out of cells, which results in inadequate proliferation-inhibiting effects of chemotherapy drugs on tumor cells. In view of the common phenomenon of clinical chemotherapy resistance, a large number of studies have been carried out on the mechanism of P-gp-mediated chemotherapy resistance and P-gp inhibitors ( 25 , 26 ).…”

Section: Introductionmentioning

confidence: 99%

Mechanism of multidrug resistance to chemotherapy mediated by P‑glycoprotein (Review)

Tian,

Lei,

Wang

et al. 2023

Int J Oncol

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Multidrug resistance (MDR) seriously limits the clinical application of chemotherapy. A mechanism underlying MDR is the overexpression of efflux transporters associated with chemotherapeutic drugs. P-glycoprotein (P-gp) is an ATP-binding cassette (ABC) transporter, which promotes MDR by pumping out chemotherapeutic drugs and reducing their intracellular concentration. To date, overexpression of P-gp has been detected in various types of chemoresistant cancer and inhibiting P-gp-related MDR has been suggested. The present review summarizes the mechanisms underlying MDR mediated by P-gp in different tumors and evaluated the related signaling pathways, with the aim of improving understanding of the current status of P-gp-mediated chemotherapeutic resistance. This review focuses on the main mechanisms of inhibiting P-gp-mediated MDR, with the aim of providing a reference for the study of reversing P-gp-mediated MDR. The first mechanism involves decreasing the efflux activity of P-gp by altering its conformation or hindering P-gp-chemotherapeutic drug binding. The second inhibitory mechanism involves inhibiting P-gp expression to reduce efflux. The third inhibitory mechanism involves knocking out the ABCB1 gene. Potential strategies that can inhibit P-gp include certain natural products, synthetic compounds and biological techniques. It is important to screen lead compounds or candidate techniques for P-gp inhibition, and to identify inhibitors by targeting the relevant signaling pathways to overcome P-gp-mediated MDR.

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“…[ 5 , 7 , 8 , 19 , 21 , 22 , 23 , 24 , 25 ] In search for a more suitable ferrite candidate, metal‐organic frameworks (MOFs) stand out due to their intrinsic superiorities such as multifunctionality, porosity, customizable size, ease of synthesis and modifiability, [ 26 , 27 , 28 ] and the possibility of achieving two‐way regulated RDH by selecting suitable metal ions and organic ligands. [ 29 , 30 ] To the best of our knowledge, no MOFs capable of two‐way regulated RDH have been reported as magnetic hyperthermia agents.…”

Section: Introductionmentioning

confidence: 99%

A Paramagnetic Metal‐Organic Framework Enhances Mild Magnetic Hyperthermia Therapy by Downregulating Heat Shock Proteins and Promoting Ferroptosis via Aggravation of Two‐Way Regulated Redox Dyshomeostasis

Wang,

Chen,

et al. 2023

Advanced Science

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Mild magnetic hyperthermia therapy (MMHT) holds great potential in treating deep‐seated tumors, but its efficacy is impaired by the upregulation of heat shock proteins (HSPs) during the treatment process. Herein, Lac‐FcMOF, a lactose derivative (Lac‐NH2) modified paramagnetic metal‐organic framework (FcMOF) with magnetic hyperthermia property and thermal stability, has been developed to enhance MMHT therapeutic efficacy. In vitro studies showed that Lac‐FcMOF aggravates two‐way regulated redox dyshomeostasis (RDH) via magnetothermal‐accelerated ferricenium ions‐mediated consumption of glutathione and ferrocene‐catalyzed generation of ∙OH to induce oxidative damage and inhibit heat shock protein 70 (HSP70) synthesis, thus significantly enhancing the anti‐cancer efficacy of MMHT. Aggravated RDH promotes glutathione peroxidase 4 inactivation and lipid peroxidation to promote ferroptosis, which further synergizes with MMHT. H22‐tumor‐bearing mice treated with Lac‐FcMOF under alternating magnetic field (AMF) demonstrated a 90.4% inhibition of tumor growth. This work therefore provides a new strategy for the simple construction of a magnetic hyperthermia agent that enables efficient MMHT by downregulating HSPs and promoting ferroptosis through the aggravation of two‐way regulated RDH.

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A hyaluronic acid modified cuprous metal-organic complex for reversing multidrug resistance via redox dyshomeostasis

Cited by 11 publications

References 52 publications

Hyaluronic Acid Nanogels: A Promising Platform for Therapeutic and Theranostic Applications

Hyaluronic Acid Nanogels: A Promising Platform for Therapeutic and Theranostic Applications

Mechanism of multidrug resistance to chemotherapy mediated by P‑glycoprotein (Review)

A Paramagnetic Metal‐Organic Framework Enhances Mild Magnetic Hyperthermia Therapy by Downregulating Heat Shock Proteins and Promoting Ferroptosis via Aggravation of Two‐Way Regulated Redox Dyshomeostasis

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