Abstract:Purpose: Osteoarthritis (OA) is a degenerative joint disease in which synergistic interactions between synovial fluid lubricants and the cartilage surface are lost. We designed a strategy to bind HA to the cartilage surface via a polymer-peptide binding system, mimicking the function of lubricin on the healthy cartilage surface. This system contains an HA binding peptide and a collagen binding peptide linked by poly(ethylene glycol) (PEG) to target and concentrate HA at the cartilage surface. This technology e… Show more
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