A hyaluronic acid-based nanogel for the co-delivery of nitric oxide (NO) and a novel antimicrobial peptide (AMP) against bacterial biofilms

Fasiku, Victoria Oluwaseun; Omolo, Calvin A.; Kiruri, Lucy W.; Devnarain, Nikita; Faya, Mbuso; Mocktar, Chunderika

doi:10.1016/j.ijbiomac.2022.02.099

Cited by 20 publications

(15 citation statements)

References 84 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Likewise, AMPs are antibacterial and antibiofilm amino acid residues that are highly advantageous due to their ability to penetrate bacteria and reach intracellular targets. 16 However, AMPs are limited by their cytotoxicity to mammalian cells. 7,8,62 Encapsulation of NO and AMP solves the issues associated with NO and AMPs while also enhancing their antibiofilm effects via combination therapy.…”

Section: Nanogels For Biofilm Therapymentioning

confidence: 99%

See 1 more Smart Citation

Nanogel-based composites for bacterial antibiofilm activity: advances, challenges, and prospects

Ali,

Al Bostami,

Al-Othman

2024

RSC Adv.

View full text Add to dashboard Cite

show abstract

Section: Nanogels For Biofilm Therapymentioning

confidence: 99%

“…1 One type of nano-sized material recently being investigated as a promising candidate for the treatment of bacterial biofilms is a types of hydrogels called nanogels. 11,12,16,17…”

Section: Introductionmentioning

confidence: 99%

Nanogel-based composites for bacterial antibiofilm activity: advances, challenges, and prospects

Ali,

Al Bostami,

Al-Othman

2024

RSC Adv.

View full text Add to dashboard Cite

show abstract

“…Because they are linked to recurring and chronic infections as well as antibiotic resistance, biofilms are a global health concern. To combat bacteria and biofilms, Fasiku et al prepared a nanogel for the simultaneous delivery of nitric oxide (NO) and antimicrobial peptide (AMP) [106]. Hyaluronic acid solution was crosslinked with divinyl sulfone to create the NO-releasing nanogel, which was then thoroughly described.…”

Section: Different Types Of Natural Polysaccharides Used In Nanogelsmentioning

confidence: 99%

Biopolymer-Based Nanogel Approach in Drug Delivery: Basic Concept and Current Developments

Altuntaş¹,

Özkan²,

Güngör³

et al. 2023

Preprint

View full text Add to dashboard Cite

Due to their increased surface area, extent of swelling and active substance loading capacity and flexibility, nanogels made from natural and synthetic polymers have gained significant interest in the scientific and industrial areas. Especially, customized design and implementation of non-toxic, biocompatible, and biodegradable micro/nano carriers makes their usage very feasible for a range of biomedical applications, including drug delivery, tissue engineering, and bioimaging. The design and application methodologies of nanogels have been outlined in this review. Additionally, the most recent advancements in nanogel biomedical applications have been discussed, with a particular emphasis on applications for the delivery of drugs and biomolecules.

show abstract

“…Bacterial biofilms are one of the major global health concerns because they have the potential to tolerate host defense systems and antibiotics, therefore, they contributed to antibiotic resistance as well as chronic and recurrent infections ( Sharma et al, 2019 ). Recently, Fasiku et al prepared a nanogel via crosslinking HA solution with divinyl sulfone for the co-delivery of NO and AMP against bacteria and biofilms ( Fasiku et al, 2022 ). In vitro antibacterial tests revealed that the NO-AMP-loaded nanogel demonstrated a greater antibacterial/antibiofilm activity when compared to NO alone.…”

Section: Hyaluronic Acid-based Nanomaterials and Bacterial Infectionsmentioning

confidence: 99%

“…In vitro antibacterial tests revealed that the NO-AMP-loaded nanogel demonstrated a greater antibacterial/antibiofilm activity when compared to NO alone. The antibiofilm results showed that catheters exposed to nanogel loaded with AMP/NO reduced biofilms of MRSA and P. aeruginosa by 12.5 and 24-folds, respectively, as compared to only NO, while nanogel loaded with only NO reduced biofilms of MRSA and P. aeruginosa by 7 and 9.4-folds, respectively ( Fasiku et al, 2022 ).…”

Section: Hyaluronic Acid-based Nanomaterials and Bacterial Infectionsmentioning

confidence: 99%

Hyaluronic Acid-Based Nanomaterials as a New Approach to the Treatment and Prevention of Bacterial Infections

Alipoor

Ayan²,

Hamblin

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Bacterial contamination of medical devices is a great concern for public health and an increasing risk for hospital-acquired infections. The ongoing increase in antibiotic-resistant bacterial strains highlights the urgent need to find new effective alternatives to antibiotics. Hyaluronic acid (HA) is a valuable polymer in biomedical applications, partly due to its bactericidal effects on different platforms such as contact lenses, cleaning solutions, wound dressings, cosmetic formulations, etc. Because the pure form of HA is rapidly hydrolyzed, nanotechnology-based approaches have been investigated to improve its clinical utility. Moreover, a combination of HA with other bactericidal molecules could improve the antibacterial effects on drug-resistant bacterial strains, and improve the management of hard-to-heal wound infections. This review summarizes the structure, production, and properties of HA, and its various platforms as a carrier in drug delivery. Herein, we discuss recent works on numerous types of HA-based nanoparticles to overcome the limitations of traditional antibiotics in the treatment of bacterial infections. Advances in the fabrication of controlled release of antimicrobial agents from HA-based nanosystems can allow the complete eradication of pathogenic microorganisms.

show abstract

A hyaluronic acid-based nanogel for the co-delivery of nitric oxide (NO) and a novel antimicrobial peptide (AMP) against bacterial biofilms

Cited by 20 publications

References 84 publications

Nanogel-based composites for bacterial antibiofilm activity: advances, challenges, and prospects

Nanogel-based composites for bacterial antibiofilm activity: advances, challenges, and prospects

Biopolymer-Based Nanogel Approach in Drug Delivery: Basic Concept and Current Developments

Hyaluronic Acid-Based Nanomaterials as a New Approach to the Treatment and Prevention of Bacterial Infections

Contact Info

Product

Resources

About