A hyaluronic acid‐based microneedle patch to treat psoriatic plaques: a pilot open trial

Lee, Ji Hae; Jung, Yu Seok; Kim, G.M.; Bae, Jung Min

doi:10.1111/bjd.15779

Cited by 35 publications

(20 citation statements)

References 6 publications

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“…Currently, cosmetologists are working on the development of dissolvable microneedle patches used to mechanically damage the skin to stimulate collagen synthesis as well as to inject various active substances (hyaluronic acid [HA], collagen, coenzymes, vitamins, etc. ), into the deep layers of the skin for general skin resurfacing, prevention and reduction in the severity of scars, and treatment of dermatologic problems such as actinic keratosis, pigmentation disorders, hyperhidrosis and striae [10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Microneedle patch based on dissolving, detachable microneedle technology for improved skin quality of the periorbital region. Part 2: Clinical Evaluation

Zvezdin

Kasatkina²,

Kasatkin³

et al. 2020

Intern J of Cosmetic Sci

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Objective Microneedle patches based on dissolving, detachable microneedle technology (Russian patent No. 2652567; US patent EFS No. 32735812; WO/2019/231360) are novel dermatological products that allow safe, painless and effective reduction of epidermal wrinkles after six procedures. The purpose of this study was two‐fold (a) to assess the safety and efficacy of microneedle patches comprising 650 microneedles containing hyaluronic and ferulic acids after 6 procedures of applying the applicator to the skin for 25 min; and (b) to correlate our previously reported ex vivo findings. Methods The microneedle applicator contains 650 microneedles, which dissolve in 25 min of exposure. The effectiveness of microneedle applicators was confirmed by a randomized split‐phase study involving 82 subjects. Applications of microneedle patches were performed at intervals of two times per week, and the effectiveness was assessed at 6 weeks after the start of the study. Results The results of the profilometric evaluation of skin smoothness demonstrated a significant reduction in the average roughness index by 65.32 ± 2.99% and in the mean skin waviness by 66.84 ± 1.6% compared with these indicators in the control group (P < 0.05). The therapeutic effect of the procedure was confirmed by an ultrasound examination that registered a 72.2 ± 5.4% and 25 ± 1.4% increase in echo‐density of the epidermis and dermis, respectively. An independent blinded skin evaluation by dermatologists revealed steady decrease in puffiness of the application area in 89.9% of patients, increased elasticity in 78.3% of the patients, and reduced severity of epidermal wrinkles in 89.9% of the patients. Conclusions The applicator with 650 soluble microneedles on its surface containing hyaluronic and ferulic acids is considered a safe, effective and convenient way to improve the skin quality in the periorbital region after six procedures. Nevertheless, additional studies of soluble microneedles are required to fully assess the amount and distribution area of the injected hyaluronic acid and other active components, as well as to detail the mechanism of action of soluble microneedles to improve skin quality.

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Section: Introductionmentioning

confidence: 99%

Microneedle patch based on dissolving, detachable microneedle technology for improved skin quality of the periorbital region. Part 2: Clinical Evaluation

Zvezdin

Kasatkina²,

Kasatkin³

et al. 2020

Intern J of Cosmetic Sci

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“…In the study, Calcipotriol-betamethasone ointment was applied on the skin and a microneedle patch was applied over this once every day for a week. The result showed that within one week of application, there was significant reduction in psoriatic plaques and thus was found efficient compared to the conventional cream application (Lee et al, 2018) Current research, advances, challenges and future trends…”

Section: Clinical Trials and Safetymentioning

confidence: 99%

A Comprehensive Review on the Potential of Microfabricated Microneedles for Effective Systemic Delivery of Drugs

Adeyemi

2019

Reinvention

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Microneedles are a new technology for percutaneous drug delivery. They are often conveyed in a series of multiple simple microneedles used on the skin to facilitate systemic or topical drug delivery. They are manufactured using various techniques and they could be hollow, solid, coated or polymeric. Although classified as an emerging but expanding field of drug delivery, they are flawed in many ways. This paper will extensively discuss (in the context of skin physiology) the use of microneedles and their feasibility in delivering medication to sites of actions in the body. This paper is a review paper and data were collated from multiple sources including journals and articles. Microneedles show great potential; however, the physiology of the skin poses a great challenge for researches in this field.

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“…In 2018, an open pilot trial in Korea that included 10 patients, assessed the enhanced role of a hyaluronic acid-based MNP as a topical therapy for psoriasis. 54 Aer a topical application of calcipotriol/betamethasone ointment (Daivobet®) daily for at least 4 weeks, resistant psoriasis plaques were selected to be the target sites of the MNP. The MNP remained on the surface of the Daivobet® pretreated plaques overnight and clinical improvement was assessed at week 0 and week 1 (Fig.…”

Section: Application Of Microneedles In Psoriasismentioning

confidence: 99%

“…These four patients were very satisfied with the additional application of the microneedle patch. Images are reproduced from ref 54…”

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confidence: 99%

Microneedles: a potential strategy in transdermal delivery and application in the management of psoriasis

2020

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A hyaluronic acid‐based microneedle patch to treat psoriatic plaques: a pilot open trial

Cited by 35 publications

References 6 publications

Microneedle patch based on dissolving, detachable microneedle technology for improved skin quality of the periorbital region. Part 2: Clinical Evaluation

Microneedle patch based on dissolving, detachable microneedle technology for improved skin quality of the periorbital region. Part 2: Clinical Evaluation

A Comprehensive Review on the Potential of Microfabricated Microneedles for Effective Systemic Delivery of Drugs

Microneedles: a potential strategy in transdermal delivery and application in the management of psoriasis

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