A humanized microbiota mouse model of ovalbumin-induced lung inflammation

Arrieta, Marie‐Claire; Sadarangani, Manish; Brown, Eric; Russell, Sarah; Nimmo, Michael; Dean, John Mark; Turvey, Stuart E.; Chan, Edmond S.; Finlay, B. Brett

doi:10.1080/19490976.2016.1182293

Cited by 37 publications

(29 citation statements)

References 24 publications

(25 reference statements)

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“…The individual opposing shift in the abundance of Lachnospira and Clostridium neonatale in the first three months of life suggests that these specific gut bacteria play a role in protecting or promoting development of a preschool age asthmatic phenotype, in addition to the previously identified roles in other atopic disorders. This bacterial dysbiosis was confirmed in other studies of the same group of authors, in which they showed the relative abundance of the bacterial genera Lachnospira and the decrease of Veillonella , Faecalibacterium , and Rothia in children at risk of asthma [53]. This reduction was accompanied by decreased levels of faecal acetate and dysregulation of enterohepatic metabolites.…”

Section: Microbiome and Asthmasupporting

confidence: 77%

The Role of the Microbiome in Asthma: The Gut–Lung Axis

Frati

Salvatori

Incorvaia

et al. 2018

IJMS

187

151

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Asthma is one of the most common chronic respiratory diseases worldwide. It affects all ages but frequently begins in childhood. Initiation and exacerbations may depend on individual susceptibility, viral infections, allergen exposure, tobacco smoke exposure, and outdoor air pollution. The aim of this review was to analyze the role of the gut–lung axis in asthma development, considering all asthma phenotypes, and to evaluate whether microbe-based therapies may be used for asthma prevention. Several studies have confirmed the role of microbiota in the regulation of immune function and the development of atopy and asthma. These clinical conditions have apparent roots in an insufficiency of early life exposure to the diverse environmental microbiota necessary to ensure colonization of the gastrointestinal and/or respiratory tracts. Commensal microbes are necessary for the induction of a balanced, tolerogenic immune system. The identification of commensal bacteria in both the gastroenteric and respiratory tracts could be an innovative and important issue. In conclusion, the function of microbiota in healthy immune response is generally acknowledged, and gut dysbacteriosis might result in chronic inflammatory respiratory disorders, particularly asthma. Further investigations are needed to improve our understanding of the role of the microbiome in inflammation and its influence on important risk factors for asthma, including tobacco smoke and host genetic features.

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Section: Microbiome and Asthmasupporting

confidence: 77%

The Role of the Microbiome in Asthma: The Gut–Lung Axis

Frati

Salvatori

Incorvaia

et al. 2018

IJMS

187

151

View full text Add to dashboard Cite

show abstract

“…This microbial profile was associated with increased production of the pro‐inflammatory metabolite 12,13 DiHOME. In a different cohort of children ages 6–17, there was no association between gut microbiota and asthma . Adults with long‐term asthma were found to have a decreased abundance of Bifidobacteria spp .…”

Section: Microbiota and Asthma (Human Evidence)mentioning

confidence: 93%

Contributions of the intestinal microbiome in lung immunity

2017

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The intestine is a critical site of immune cell development that not only controls intestinal immunity but extra-intestinal immunity as well. Recent findings have highlighted important roles for gut microbiota in shaping lung inflammation. Here, we discuss interactions between the microbiota and immune system including T cells, protective effects of microbiota on lung infections, the role of diet in shaping the composition of gut micro-biota and susceptibility to asthma, epidemiologic evidence implicating antibiotic use and microbiota in asthma and clinical trials investigating probiotics as potential treatments for atopy and asthma. The systemic effects of gut microbiota are partially attributed to their generating metabolites including short chain fatty acids, which can suppress lung inflammation through the activation of G protein-coupled receptors. Thus, studying the interactions between microbiota and immune cells can lead to the identification of therapeutic targets for chronic lower respiratory diseases.

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“…Nevertheless, the causal role of dysfunctional gut microbiota in driving IBD flares of individual patients is poorly understood and requires the implementation of translational models 19 . Transplantation of fecal microbiota from patients into germ-free recipient mice has been used to recapitulate a variety of disease phenotypes, including IBD, and therefore provides a clinically relevant tool to mechanistically address microbe-host interactions [20][21][22][23] . In this study, we took advantage of autologous hematopoietic stem cell transplantation (HSCT), a therapeutic intervention that has significant and prolonged effects on a subset of severe and highly refractory CD patients, bringing them into drug-free remission, with a proportion of these patients relapsing over time.…”

mentioning

confidence: 99%

Integrated microbiota and metabolite profiles link Crohn’s disease to sulfur metabolism

et al. 2020

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Gut microbial and metabolite alterations have been linked to the pathogenesis of inflammatory bowel diseases. Here we perform a multi-omics microbiome and metabolite analysis of a longitudinal cohort of Crohn's disease patients undergoing autologous hematopoietic stem cell transplantation, and investigational therapy that induces drug free remission in a subset of patients. Via comparison of patients who responded and maintained remission, responded but experienced disease relapse and patients who did not respond to therapy, we identify shared functional signatures that correlate with disease activity despite the variability of gut microbiota profiles at taxonomic level. These signatures reflect the disease state when transferred to gnotobiotic mice. Taken together, the integration of microbiome and metabolite profiles from human cohort and mice improves the predictive modelling of disease outcome, and allows the identification of a network of bacteria-metabolite interactions involving sulfur metabolism as a key mechanism linked to disease activity in Crohn's disease.

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A humanized microbiota mouse model of ovalbumin-induced lung inflammation

Cited by 37 publications

References 24 publications

The Role of the Microbiome in Asthma: The Gut–Lung Axis

The Role of the Microbiome in Asthma: The Gut–Lung Axis

Contributions of the intestinal microbiome in lung immunity

Integrated microbiota and metabolite profiles link Crohn’s disease to sulfur metabolism

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